产品: PGRMC1 小鼠 单克隆 抗体
货号: BF8084
描述: Mouse monoclonal antibody to PGRMC1
应用: WB
反应: Human
预测: Pig, Bovine, Horse, Sheep, Rabbit
分子量: 21kDa; 22kD(Calculated).
蛋白号: O00264

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产品描述

来源:
Mouse
应用:
WB 1:1000-1:10000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human
克隆:
Monoclonal [AFfirm8084]
特异性:
PGRMC1 Antibody detects endogenous levels of total PGRMC1.
偶联:
Unconjugated.
纯化:
Affinity-chromatography.
保存:
Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

HPR6.6; Membrane associated progesterone receptor component 1; Membrane-associated progesterone receptor component 1; mPR; PGRC1_HUMAN; PGRMC; Pgrmc1; Progesterone binding protein; Progesterone receptor membrane component 1;

抗原和靶标

免疫原:

A synthesized peptide derived from human PGRMC1, corresponding to a region within C-terminal amino acids.

Uniprot:
基因/基因ID:
表达:
O00264 PGRC1_HUMAN:

Widely expressed, with highest expression in liver and kidney.

描述:
This gene encodes a putative membrane-associated progesterone steroid receptor. The protein is expressed predominantly in the liver and kidney.
序列:
MAAEDVVATGADPSDLESGGLLHEIFTSPLNLLLLGLCIFLLYKIVRGDQPAASGDSDDDEPPPLPRLKRRDFTPAELRRFDGVQDPRILMAINGKVFDVTKGRKFYGPEGPYGVFAGRDASRGLATFCLDKEALKDEYDDLSDLTAAQQETLSDWESQFTFKYHHVGKLLKEGEEPTVYSDEEEPKDESARKND

翻译修饰 - O00264 作为底物

Site PTM Type Enzyme
R47 Methylation
S54 Phosphorylation
S57 Phosphorylation
T74 Phosphorylation
R79 Methylation
K96 Acetylation
K96 Ubiquitination
T101 Phosphorylation
K102 Ubiquitination
K105 Ubiquitination
Y107 Phosphorylation
Y113 Phosphorylation
R119 Methylation
K132 Ubiquitination
K136 Ubiquitination
Y139 Phosphorylation
S143 Phosphorylation
T146 Phosphorylation
T152 Phosphorylation
S154 Phosphorylation
K163 Ubiquitination
K169 Ubiquitination
K172 Ubiquitination
T178 Phosphorylation
Y180 Phosphorylation
S181 Phosphorylation
K187 Ubiquitination
S190 Phosphorylation

研究背景

功能:

Component of a progesterone-binding protein complex. Binds progesterone. Has many reported cellular functions (heme homeostasis, interaction with CYPs).

细胞定位:

Microsome membrane>Single-pass membrane protein. Smooth endoplasmic reticulum membrane>Single-pass membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Widely expressed, with highest expression in liver and kidney.

亚基结构:

Homodimer. Forms stable homodimer through hydrophobic heme-heme stacking interactions.

蛋白家族:

The cytochrome b5 heme-binding domain lacks the conserved iron-binding His residues at positions 107 and 131.

Belongs to the cytochrome b5 family. MAPR subfamily.

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