AFfirm™ FN3K Mouse Monoclonal Antibody - #BF8088

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产品: FN3K 小鼠 单克隆 抗体
货号: BF8088
描述: Mouse monoclonal antibody to FN3K
应用: WB
反应: Human, Mouse, Rat
预测: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken
分子量: 35 kDa; 35kD(Calculated).
蛋白号: Q9H479

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   规格 价格 库存
 100ul RMB¥ 688 2300 现货

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MSDS
说明书
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实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Mouse
应用:
WB 1:1000-1:10000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
克隆:
Monoclonal [AFfirm8088]
特异性:
FN3K Antibody detects endogenous levels of total FN3K.
偶联:
Unconjugated.
纯化:
Affinity-chromatography.
保存:
Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

2310074G21Rik; Fnsk; Fructosamine 3 kinase; RP23-293H17.4;

抗原和靶标

免疫原:
Uniprot:

Q9H479(FN3K_HUMAN) >>Visit HPA database.

基因/基因ID:
FN3K(64122)
表达:
Q9H479 FN3K_HUMAN:

Widely expressed (PubMed:11522682). Expressed in erythrocytes (PubMed:11016445).

序列:
MEQLLRAELRTATLRAFGGPGAGCISEGRAYDTDAGPVFVKVNRRTQARQMFEGEVASLEALRSTGLVRVPRPMKVIDLPGGGAAFVMEHLKMKSLSSQASKLGEQMADLHLYNQKLREKLKEEENTVGRRGEGAEPQYVDKFGFHTVTCCGFIPQVNEWQDDWPTFFARHRLQAQLDLIEKDYADREARELWSRLQVKIPDLFCGLEIVPALLHGDLWSGNVAEDDVGPIIYDPASFYGHSEFELAIALMFGGFPRSFFTAYHRKIPKAPGFDQRLLLYQLFNYLNHWNHFGREYRSPSLGTMRRLLK

翻译修饰 - Q9H479 作为底物

Site PTM Type Enzyme
M1 Acetylation
C24 S-Nitrosylation
S97 Phosphorylation
K102 Ubiquitination
K116 Ubiquitination
S258 Phosphorylation
Y263 Phosphorylation
Y296 Phosphorylation
S298 Phosphorylation

研究背景

功能:

Fructosamine-3-kinase involved in protein deglycation by mediating phosphorylation of fructoselysine residues on glycated proteins, to generate fructoselysine-3 phosphate. Fructoselysine-3 phosphate adducts are unstable and decompose under physiological conditions. Involved in intracellular deglycation in erythrocytes. Involved in the response to oxidative stress by mediating deglycation of NFE2L2/NRF2, glycation impairing NFE2L2/NRF2 function (By similarity). Also able to phosphorylate psicosamines and ribulosamines.

组织特异性:

Widely expressed. Expressed in erythrocytes.

亚基结构:

Monomer.

蛋白家族:

Belongs to the fructosamine kinase family.

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