产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
展开/折叠
BC033596; CCDC 131; CCDC131; Coiled coil domain containing 131; Coiled-coil domain-containing protein 131; DKFZp686A0722; KIAA0546; MGC23401; MGC90200; Proline/serine rich coiled coil 2; Proline/serine-rich coiled-coil protein 2; PSRC 2; ZC3H1_HUMAN; ZFC3H1; Zinc finger C3H1 domain-containing protein;
抗原和靶标
- O60293 ZC3H1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MATADTPAPASSGLSPKEEGELEDGEISDDDNNSQIRSRSSSSSSGGGLLPYPRRRPPHSARGGGSGGGGGSSSSSSSSQQQLRNFSRSRHASERGHLRGPSSYRPKEPFRSHPPSVRMPSSSLSESSPRPSFWERSHLALDRFRFRGRPYRGGSRWSRGRGVGERGGKPGCRPPLGGGAGSGFSSSQSWREPSPPRKSSKSFGRSPSRKQNYSSKNENCVEETFEDLLLKYKQIQLELECINKDEKLALSSKEENVQEDPKTLNFEDQTSTDNVSITKDSSKEVAPEEKTQVKTFQAFELKPLRQKLTLPGDKNRLKKVKDGAKPLSLKSDTTDSSQGLQDKEQNLTRRISTSDILSEKKLGEDEEELSELQLRLLALQSASKKWQQKEQQVMKESKEKLTKTKTVQQKVKTSTKTHSAKKVSTTAKQALRKQQTKAWKKLQQQKEQERQKEEDQRKQAEEEERRKREEEIRKIRDLSNQEEQYNRFMKLVGGKRRSRSKSSDPDLRRSLDKQPTDSGGGIYQYDNYEEVAMDTDSETSSPAPSPVQPPFFSECSLGYFSPAPSLSLPPPPQVSSLPPLSQPYVEGLCVSLEPLPPLPPLPPLPPEDPEQPPKPPFADEEEEEEMLLREELLKSLANKRAFKPEETSSNSDPPSPPVLNNSHPVPRSNLSIVSINTVSQPRIQNPKFHRGPRLPRTVISLPKHKSVVVTLNDSDDSESDGEASKSTNSVFGGLESMIKEARRTAEQASKPKVPPKSEKENDPLRTPEALPEEKKIEYRLLKEEIANREKQRLIKSDQLKTSSSSPANSDVEIDGIGRIAMVTKQVTDAESKLKKHRILLMKDESVLKNLVQQEAKKKESVRNAEAKITKLTEQLQATEKILNVNRMFLKKLQEQIHRVQQRVTIKKALTLKYGEELARAKAVASKEIGKRKLEQDRFGPNKMMRLDSSPVSSPRKHSAELIAMEKRRLQKLEYEYALKIQKLKEARALKAKEQQNISPVVEEEPEFSLPQPSLHDLTQDKLTLDTEENDVDDEILSGSSRERRRSFLESNYFTKPNLKHTDTANKECINKLNKNTVEKPELFLGLKIGELQKLYSKADSLKQLILKTTTGITEKVLHGQEISVDVDFVTAQSKTMEVKPCPFRPYHSPLLVFKSYRFSPYYRTKEKLPLSSVSYSNMIEPDQCFCRFDLTGTCNDDDCQWQHIQDYTLSRKQLFQDILSYNLSLIGCAETSTNEEITASAEKYVEKLFGVNKDRMSMDQMAVLLVSNINESKGHTPPFTTYKDKRKWKPKFWRKPISDNSFSSDEEQSTGPIKYAFQPENQINVPALDTVVTPDDVRYFTNETDDIANLEASVLENPSHVQLWLKLAYKYLNQNEGECSESLDSALNVLARALENNKDNPEIWCHYLRLFSKRGTKDEVQEMCETAVEYAPDYQSFWTFLHLESTFEEKDYVCERMLEFLMGAAKQETSNILSFQLLEALLFRVQLHIFTGRCQSALAILQNALKSANDGIVAEYLKTSDRCLAWLAYIHLIEFNILPSKFYDPSNDNPSRIVNTESFVMPWQAVQDVKTNPDMLLAVFEDAVKACTDESLAVEERIEACLPLYTNMIALHQLLERYEAAMELCKSLLESCPINCQLLEALVALYLQTNQHDKARAVWLTAFEKNPQNAEVFYHMCKFFILQNRGDNLLPFLRKFIASFFKPGFEKYNNLDLFRYLLNIPGPIDIPSRLCKGNFDDDMFNHQVPYLWLIYCLCHPLQSSIKETVEAYEAALGVAMRCDIVQKIWMDYLVFANNRAAGSRNKVQEFKFFTDLVNRCLVTVPARYPIPFSSADYWSNYEFHNRVIFFYLSCVPKTQHSKTLERFCSVMPANSGLALRLLQHEWEESNVQILKLQAKMFTYNIPTCLATWKIAIAAEIVLKGQREVHRLYQRALQKLPLCASLWKDQLLFEASEGGKTDNLRKLVSKCQEIGVSLNELLNLNSNKTESKNH
翻译修饰 - O60293 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| S15 | Phosphorylation | Uniprot | |
| S28 | Phosphorylation | Uniprot | |
| S34 | Phosphorylation | Uniprot | |
| S42 | Phosphorylation | Uniprot | |
| S45 | Phosphorylation | Uniprot | |
| Y52 | Phosphorylation | Uniprot | |
| R55 | Methylation | Uniprot | |
| R56 | Methylation | Uniprot | |
| R62 | Methylation | Uniprot | |
| R84 | Methylation | Uniprot | |
| S87 | Phosphorylation | Uniprot | |
| S89 | Phosphorylation | Uniprot | |
| R95 | Methylation | Uniprot | |
| R99 | Methylation | Uniprot | |
| R105 | Methylation | Uniprot | |
| R118 | Methylation | Uniprot | |
| S121 | Phosphorylation | Uniprot | |
| S122 | Phosphorylation | Uniprot | |
| S123 | Phosphorylation | Uniprot | |
| S125 | Phosphorylation | Uniprot | |
| S127 | Phosphorylation | Uniprot | |
| S128 | Phosphorylation | Uniprot | |
| R143 | Methylation | Uniprot | |
| S194 | Phosphorylation | Uniprot | |
| S199 | Phosphorylation | Uniprot | |
| S200 | Phosphorylation | Uniprot | |
| S202 | Phosphorylation | Uniprot | |
| S206 | Phosphorylation | Uniprot | |
| S208 | Phosphorylation | Uniprot | |
| S251 | Phosphorylation | Uniprot | |
| K253 | Sumoylation | Uniprot | |
| T309 | Phosphorylation | Uniprot | |
| K319 | Methylation | Uniprot | |
| S328 | Phosphorylation | Uniprot | |
| S337 | Phosphorylation | Uniprot | |
| K343 | Ubiquitination | Uniprot | |
| S352 | Phosphorylation | Uniprot | |
| T353 | Phosphorylation | Uniprot | |
| S354 | Phosphorylation | Uniprot | |
| K361 | Ubiquitination | Uniprot | |
| S381 | Phosphorylation | Uniprot | |
| S383 | Phosphorylation | Uniprot | |
| K384 | Ubiquitination | Uniprot | |
| T426 | Phosphorylation | Uniprot | |
| K428 | Ubiquitination | Uniprot | |
| S500 | Phosphorylation | Uniprot | |
| S502 | Phosphorylation | Uniprot | |
| S510 | Phosphorylation | Uniprot | |
| S561 | Phosphorylation | Uniprot | |
| S651 | Phosphorylation | Uniprot | |
| S655 | Phosphorylation | Uniprot | |
| S662 | Phosphorylation | Uniprot | |
| S714 | Phosphorylation | Uniprot | |
| S717 | Phosphorylation | Uniprot | |
| S719 | Phosphorylation | Uniprot | |
| S724 | Phosphorylation | Uniprot | |
| S726 | Phosphorylation | Uniprot | |
| S729 | Phosphorylation | Uniprot | |
| S757 | Phosphorylation | Uniprot | |
| T766 | Phosphorylation | Uniprot | |
| K775 | Acetylation | Uniprot | |
| K782 | Ubiquitination | Uniprot | |
| K795 | Ubiquitination | Uniprot | |
| K800 | Ubiquitination | Uniprot | |
| T801 | Phosphorylation | Uniprot | |
| S802 | Phosphorylation | Uniprot | |
| S803 | Phosphorylation | Uniprot | |
| S804 | Phosphorylation | Uniprot | |
| S805 | Phosphorylation | Uniprot | |
| S809 | Phosphorylation | Uniprot | |
| K832 | Ubiquitination | Uniprot | |
| K848 | Ubiquitination | Uniprot | |
| K880 | Ubiquitination | Uniprot | |
| K921 | Acetylation | Uniprot | |
| K926 | Acetylation | Uniprot | |
| K932 | Acetylation | Uniprot | |
| S948 | Phosphorylation | Uniprot | |
| S949 | Phosphorylation | Uniprot | |
| S952 | Phosphorylation | Uniprot | |
| S953 | Phosphorylation | Uniprot | |
| K966 | Ubiquitination | Uniprot | |
| S998 | Phosphorylation | Uniprot | |
| S1046 | Phosphorylation | Uniprot | |
| S1050 | Phosphorylation | Uniprot | |
| T1076 | Phosphorylation | Uniprot | |
| S1096 | Phosphorylation | Uniprot | |
| S1100 | Phosphorylation | Uniprot | |
| K1102 | Ubiquitination | Uniprot | |
| S1148 | Phosphorylation | Uniprot | |
| Y1161 | Phosphorylation | Uniprot | |
| Y1162 | Phosphorylation | Uniprot | |
| Y1244 | Phosphorylation | Uniprot | |
| K1247 | Ubiquitination | Uniprot | |
| T1276 | Phosphorylation | Uniprot | |
| K1287 | Methylation | Uniprot | |
| K1295 | Ubiquitination | Uniprot | |
| S1298 | Phosphorylation | Uniprot | |
| S1301 | Phosphorylation | Uniprot | |
| S1303 | Phosphorylation | Uniprot | |
| S1304 | Phosphorylation | Uniprot | |
| S1849 | Phosphorylation | Uniprot | |
| K1955 | Ubiquitination | Uniprot |
研究背景
Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters.
Nucleus.
Note: Excluded from the nucleolus.
Component of the poly(A) tail exosome targeting (PAXT) complex made of accessory factors, such as PABPN1, ZFC3H1 and MTREX, and which directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. Co-localizes with component of the CBC-ARS2 (CBCA) complex. Binds to RNA exosome components. Interacts with NCBP1/CBP80, ZC3H18, MTREX and PABPN1 in a RNase-insensitive manner, and with PABPC4, PABPC1 and ZC3H14 in a RNase-sensitive manner.
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