AFfirm™ CCDC131 Mouse Monoclonal Antibody - #BF8099

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产品: CCDC131 小鼠 单克隆 抗体
货号: BF8099
描述: Mouse monoclonal antibody to CCDC131
应用: WB
反应: Human, Rat
预测: Pig, Bovine, Horse, Sheep, Rabbit, Dog
分子量: 226 kDa; 226kD(Calculated).
蛋白号: O60293

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   规格 价格 库存
 100ul RMB¥ 688 2300 现货

货期: 当天发货

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MSDS
说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Mouse
应用:
WB 1:500-1:3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Rat
克隆:
Monoclonal [AFfirm8099]
特异性:
CCDC131 Antibody detects endogenous levels of total CCDC131.
偶联:
Unconjugated.
纯化:
Affinity-chromatography.
保存:
Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

BC033596; CCDC 131; CCDC131; Coiled coil domain containing 131; Coiled-coil domain-containing protein 131; DKFZp686A0722; KIAA0546; MGC23401; MGC90200; Proline/serine rich coiled coil 2; Proline/serine-rich coiled-coil protein 2; PSRC 2; ZC3H1_HUMAN; ZFC3H1; Zinc finger C3H1 domain-containing protein;

抗原和靶标

免疫原:
Uniprot:

O60293(ZC3H1_HUMAN) >>Visit HPA database.

基因/基因ID:
ZFC3H1(196441)
序列:
MATADTPAPASSGLSPKEEGELEDGEISDDDNNSQIRSRSSSSSSGGGLLPYPRRRPPHSARGGGSGGGGGSSSSSSSSQQQLRNFSRSRHASERGHLRGPSSYRPKEPFRSHPPSVRMPSSSLSESSPRPSFWERSHLALDRFRFRGRPYRGGSRWSRGRGVGERGGKPGCRPPLGGGAGSGFSSSQSWREPSPPRKSSKSFGRSPSRKQNYSSKNENCVEETFEDLLLKYKQIQLELECINKDEKLALSSKEENVQEDPKTLNFEDQTSTDNVSITKDSSKEVAPEEKTQVKTFQAFELKPLRQKLTLPGDKNRLKKVKDGAKPLSLKSDTTDSSQGLQDKEQNLTRRISTSDILSEKKLGEDEEELSELQLRLLALQSASKKWQQKEQQVMKESKEKLTKTKTVQQKVKTSTKTHSAKKVSTTAKQALRKQQTKAWKKLQQQKEQERQKEEDQRKQAEEEERRKREEEIRKIRDLSNQEEQYNRFMKLVGGKRRSRSKSSDPDLRRSLDKQPTDSGGGIYQYDNYEEVAMDTDSETSSPAPSPVQPPFFSECSLGYFSPAPSLSLPPPPQVSSLPPLSQPYVEGLCVSLEPLPPLPPLPPLPPEDPEQPPKPPFADEEEEEEMLLREELLKSLANKRAFKPEETSSNSDPPSPPVLNNSHPVPRSNLSIVSINTVSQPRIQNPKFHRGPRLPRTVISLPKHKSVVVTLNDSDDSESDGEASKSTNSVFGGLESMIKEARRTAEQASKPKVPPKSEKENDPLRTPEALPEEKKIEYRLLKEEIANREKQRLIKSDQLKTSSSSPANSDVEIDGIGRIAMVTKQVTDAESKLKKHRILLMKDESVLKNLVQQEAKKKESVRNAEAKITKLTEQLQATEKILNVNRMFLKKLQEQIHRVQQRVTIKKALTLKYGEELARAKAVASKEIGKRKLEQDRFGPNKMMRLDSSPVSSPRKHSAELIAMEKRRLQKLEYEYALKIQKLKEARALKAKEQQNISPVVEEEPEFSLPQPSLHDLTQDKLTLDTEENDVDDEILSGSSRERRRSFLESNYFTKPNLKHTDTANKECINKLNKNTVEKPELFLGLKIGELQKLYSKADSLKQLILKTTTGITEKVLHGQEISVDVDFVTAQSKTMEVKPCPFRPYHSPLLVFKSYRFSPYYRTKEKLPLSSVSYSNMIEPDQCFCRFDLTGTCNDDDCQWQHIQDYTLSRKQLFQDILSYNLSLIGCAETSTNEEITASAEKYVEKLFGVNKDRMSMDQMAVLLVSNINESKGHTPPFTTYKDKRKWKPKFWRKPISDNSFSSDEEQSTGPIKYAFQPENQINVPALDTVVTPDDVRYFTNETDDIANLEASVLENPSHVQLWLKLAYKYLNQNEGECSESLDSALNVLARALENNKDNPEIWCHYLRLFSKRGTKDEVQEMCETAVEYAPDYQSFWTFLHLESTFEEKDYVCERMLEFLMGAAKQETSNILSFQLLEALLFRVQLHIFTGRCQSALAILQNALKSANDGIVAEYLKTSDRCLAWLAYIHLIEFNILPSKFYDPSNDNPSRIVNTESFVMPWQAVQDVKTNPDMLLAVFEDAVKACTDESLAVEERIEACLPLYTNMIALHQLLERYEAAMELCKSLLESCPINCQLLEALVALYLQTNQHDKARAVWLTAFEKNPQNAEVFYHMCKFFILQNRGDNLLPFLRKFIASFFKPGFEKYNNLDLFRYLLNIPGPIDIPSRLCKGNFDDDMFNHQVPYLWLIYCLCHPLQSSIKETVEAYEAALGVAMRCDIVQKIWMDYLVFANNRAAGSRNKVQEFKFFTDLVNRCLVTVPARYPIPFSSADYWSNYEFHNRVIFFYLSCVPKTQHSKTLERFCSVMPANSGLALRLLQHEWEESNVQILKLQAKMFTYNIPTCLATWKIAIAAEIVLKGQREVHRLYQRALQKLPLCASLWKDQLLFEASEGGKTDNLRKLVSKCQEIGVSLNELLNLNSNKTESKNH

翻译修饰 - O60293 作为底物

Site PTM Type Enzyme
A2 Acetylation
S15 Phosphorylation
S28 Phosphorylation
S34 Phosphorylation
S42 Phosphorylation
S45 Phosphorylation
Y52 Phosphorylation
R55 Methylation
R56 Methylation
R62 Methylation
R84 Methylation
S87 Phosphorylation
S89 Phosphorylation
R95 Methylation
R99 Methylation
R105 Methylation
R118 Methylation
S121 Phosphorylation
S122 Phosphorylation
S123 Phosphorylation
S125 Phosphorylation
S127 Phosphorylation
S128 Phosphorylation
R143 Methylation
S194 Phosphorylation
S199 Phosphorylation
S200 Phosphorylation
S202 Phosphorylation
S206 Phosphorylation
S208 Phosphorylation
S251 Phosphorylation
K253 Sumoylation
T309 Phosphorylation
K319 Methylation
S328 Phosphorylation
S337 Phosphorylation
K343 Ubiquitination
S352 Phosphorylation
T353 Phosphorylation
S354 Phosphorylation
K361 Ubiquitination
S381 Phosphorylation
S383 Phosphorylation
K384 Ubiquitination
T426 Phosphorylation
K428 Ubiquitination
S500 Phosphorylation
S502 Phosphorylation
S510 Phosphorylation
S561 Phosphorylation
S651 Phosphorylation
S655 Phosphorylation
S662 Phosphorylation
S714 Phosphorylation
S717 Phosphorylation
S719 Phosphorylation
S724 Phosphorylation
S726 Phosphorylation
S729 Phosphorylation
S757 Phosphorylation
T766 Phosphorylation
K775 Acetylation
K782 Ubiquitination
K795 Ubiquitination
K800 Ubiquitination
T801 Phosphorylation
S802 Phosphorylation
S803 Phosphorylation
S804 Phosphorylation
S805 Phosphorylation
S809 Phosphorylation
K832 Ubiquitination
K848 Ubiquitination
K880 Ubiquitination
K921 Acetylation
K926 Acetylation
K932 Acetylation
S948 Phosphorylation
S949 Phosphorylation
S952 Phosphorylation
S953 Phosphorylation
K966 Ubiquitination
S998 Phosphorylation
S1046 Phosphorylation
S1050 Phosphorylation
T1076 Phosphorylation
S1096 Phosphorylation
S1100 Phosphorylation
K1102 Ubiquitination
S1148 Phosphorylation
Y1161 Phosphorylation
Y1162 Phosphorylation
Y1244 Phosphorylation
K1247 Ubiquitination
T1276 Phosphorylation
K1287 Methylation
K1295 Ubiquitination
S1298 Phosphorylation
S1301 Phosphorylation
S1303 Phosphorylation
S1304 Phosphorylation
S1849 Phosphorylation
K1955 Ubiquitination

研究背景

功能:

Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters.

细胞定位:

Nucleus.
Note: Excluded from the nucleolus.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
亚基结构:

Component of the poly(A) tail exosome targeting (PAXT) complex made of accessory factors, such as PABPN1, ZFC3H1 and MTREX, and which directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. Co-localizes with component of the CBC-ARS2 (CBCA) complex. Binds to RNA exosome components. Interacts with NCBP1/CBP80, ZC3H18, MTREX and PABPN1 in a RNase-insensitive manner, and with PABPC4, PABPC1 and ZC3H14 in a RNase-sensitive manner.

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