产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
展开/折叠
Signal transducer and activator of transcription 4; SLEB11; STAT4; STAT4_HUMAN;
抗原和靶标
- Q14765 STAT4_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSQWNQVQQLEIKFLEQVDQFYDDNFPMEIRHLLAQWIENQDWEAASNNETMATILLQNLLIQLDEQLGRVSKEKNLLLIHNLKRIRKVLQGKFHGNPMHVAVVISNCLREERRILAAANMPVQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQDEFDYRYKTIQTMDQSDKNSAMVNQEVLTLQEMLNSLDFKRKEALSKMTQIIHETDLLMNTMLIEELQDWKRRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQLEKLEEQSTKMTYEGDPIPMQRTHMLERVTFLIYNLFKNSFVVERQPCMPTHPQRPLVLKTLIQFTVKLRLLIKLPELNYQVKVKASIDKNVSTLSNRRFVLCGTNVKAMSIEESSNGSLSVEFRHLQPKEMKSSAGGKGNEGCHMVTEELHSITFETQICLYGLTIDLETSSLPVVMISNVSQLPNAWASIIWYNVSTNDSQNLVFFNNPPPATLSQLLEVMSWQFSSYVGRGLNSDQLHMLAEKLTVQSSYSDGHLTWAKFCKEHLPGKSFTFWTWLEAILDLIKKHILPLWIDGYVMGFVSKEKERLLLKDKMPGTFLLRFSESHLGGITFTWVDHSESGEVRFHSVEPYNKGRLSALPFADILRDYKVIMAENIPENPLKYLYPDIPKDKAFGKHYSSQPCEVSRPTERGDKGYVPSVFIPISTIRSDSTEPHSPSDLLPMSPSVYAVLRENLSPTTIETAMKSPYSAE
翻译修饰 - Q14765 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S130 | Phosphorylation | Uniprot | |
| S137 | Phosphorylation | Uniprot | |
| K151 | Ubiquitination | Uniprot | |
| T284 | Phosphorylation | Uniprot | |
| T287 | Phosphorylation | Uniprot | |
| Y288 | Phosphorylation | Uniprot | |
| T298 | Phosphorylation | Uniprot | |
| S362 | Phosphorylation | Uniprot | |
| T369 | Phosphorylation | Uniprot | |
| S371 | Phosphorylation | Uniprot | |
| S386 | Phosphorylation | Uniprot | |
| S394 | Phosphorylation | Uniprot | |
| S396 | Phosphorylation | Uniprot | |
| K562 | Ubiquitination | Uniprot | |
| Y645 | Phosphorylation | Uniprot | |
| Y693 | Phosphorylation | O60674 (JAK2) | Uniprot |
| S713 | Phosphorylation | Uniprot | |
| S721 | Phosphorylation | Q16539 (MAPK14) , P52564 (MAP2K6) | Uniprot |
| S733 | Phosphorylation | Uniprot | |
| S743 | Phosphorylation | Uniprot | |
| Y745 | Phosphorylation | Uniprot | |
| S746 | Phosphorylation | Uniprot |
研究背景
Carries out a dual function: signal transduction and activation of transcription. Involved in IL12 signaling.
Tyrosine phosphorylated. Serine phosphorylation is also required for maximal transcriptional activity (By similarity).
Cytoplasm. Nucleus.
Note: Translocated into the nucleus in response to phosphorylation.
Forms a homodimer or a heterodimer with a related family member. Interacts with ARL2BP (By similarity). The SH2 domain interacts, in vitro, with IL12RB2 via a short cytoplasmic domain.
Belongs to the transcription factor STAT family.
研究领域
· Cellular Processes > Cell growth and death > Necroptosis. (View pathway)
· Environmental Information Processing > Signal transduction > Jak-STAT signaling pathway. (View pathway)
· Human Diseases > Infectious diseases: Viral > Hepatitis B.
· Human Diseases > Cancers: Overview > Pathways in cancer. (View pathway)
· Human Diseases > Immune diseases > Inflammatory bowel disease (IBD).
· Organismal Systems > Immune system > Th1 and Th2 cell differentiation. (View pathway)
限制条款
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