产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
展开/折叠
G protein coupled receptor 120; G protein coupled receptor 129; G protein coupled receptor GT01; G protein coupled receptor PGR 4; G protein coupled receptor PGR4; G-protein coupled receptor 120; G-protein coupled receptor 129; G-protein coupled receptor GT01; G-protein coupled receptor PGR4; GPR 120; GPR 129; GPR120; GPR129; GT01; HGNC:19345; MGC119984; O3FA1_HUMAN; O3FAR1; Omega-3 fatty acid receptor 1; PGR 4; PGR4;
抗原和靶标
Abundant expression in the intestinal tract. Highly expressed in adipose tissue, small intestine and pancreas.
- Q5NUL3 FFAR4_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSPECARAAGDAPLRSLEQANRTRFPFFSDVKGDHRLVLAAVETTVLVLIFAVSLLGNVCALVLVARRRRRGATACLVLNLFCADLLFISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRVVPQRLPGADQEISICTLIWPTIPGEISWDVSFVTLNFLVPGLVIVISYSKILQTSEHLLDARAVVTHSEITKASRKRLTVSLAYSESHQIRVSQQDFRLFRTLFLLMVSFFIMWSPIIITILLILIQNFKQDLVIWPSLFFWVVAFTFANSALNPILYNMTLCRNEWKKIFCCFWFPEKGAILTDTSVKRNDLSIISG
翻译修饰 - Q5NUL3 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S253 | Phosphorylation | Uniprot | |
| T258 | Phosphorylation | Uniprot | |
| Y263 | Phosphorylation | Uniprot | |
| S266 | Phosphorylation | Uniprot | |
| T363 | Phosphorylation | Uniprot | |
| S366 | Phosphorylation | Uniprot |
研究背景
Receptor for medium and long-chain free fatty acids (FFAs). Signals via a G(q)/G(11)-coupled pathway. Acts as a receptor for omega-3 fatty acids and mediates robust anti-inflammatory effects, particularly in macrophages and fat cells. The anti-inflammatory effects involve inhibition of TAK1 through a beta-arrestin 2 (ARRB2)/TAB1-dependent effect, but independent of the G(q)/G(11)-coupled pathway. Mediates potent insulin sensitizing and antidiabetic effects by repressing macrophage-induced tissue inflammation. May mediate the taste of fatty acids. Mediates FFA-induced inhibition of apoptosis in enteroendocrine cells. May play a role in the regulation of adipocyte development and differentiation.
Phosphorylated. FFA stimulation facilitates phosphorylation.
Cell membrane>Multi-pass membrane protein.
Note: Colocalized with ARRB2 following DHA treatment.
Abundant expression in the intestinal tract. Highly expressed in adipose tissue, small intestine and pancreas.
Interacts with ARRB2 following docosahexaenoic acid (DHA) stimulation.
Belongs to the G-protein coupled receptor 1 family.
限制条款
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