产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
展开/折叠
CACH; CLE; EI2BE_HUMAN; EIF 2B; eIF 2B GDP GTP exchange factor; eIF 2B GDP GTP exchange factor subunit epsilon; eIF-2B GDP-GTP exchange factor subunit epsilon; EIF2B; EIF2B5; EIF2BE; EIF2Bepsilon; Eukaryotic Translation Initiation Factor 2 Beta Epsilon; Eukaryotic translation initiation factor 2B subunit 5 epsilon 82kDa; Eukaryotic translation initiation factor 2B subunit 5 epsilon; LVWM; Translation initiation factor eIF 2B subunit epsilon; Translation initiation factor eIF-2B subunit epsilon;
抗原和靶标
- Q13144 EI2BE_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAAPVVAPPGVVVSRANKRSGAGPGGSGGGGARGAEEEPPPPLQAVLVADSFDRRFFPISKDQPRVLLPLANVALIDYTLEFLTATGVQETFVFCCWKAAQIKEHLLKSKWCRPTSLNVVRIITSELYRSLGDVLRDVDAKALVRSDFLLVYGDVISNINITRALEEHRLRRKLEKNVSVMTMIFKESSPSHPTRCHEDNVVVAVDSTTNRVLHFQKTQGLRRFAFPLSLFQGSSDGVEVRYDLLDCHISICSPQVAQLFTDNFDYQTRDDFVRGLLVNEEILGNQIHMHVTAKEYGARVSNLHMYSAVCADVIRRWVYPLTPEANFTDSTTQSCTHSRHNIYRGPEVSLGHGSILEENVLLGSGTVIGSNCFITNSVIGPGCHIGDNVVLDQTYLWQGVRVAAGAQIHQSLLCDNAEVKERVTLKPRSVLTSQVVVGPNITLPEGSVISLHPPDAEEDEDDGEFSDDSGADQEKDKVKMKGYNPAEVGAAGKGYLWKAAGMNMEEEEELQQNLWGLKINMEEESESESEQSMDSEEPDSRGGSPQMDDIKVFQNEVLGTLQRGKEENISCDNLVLEINSLKYAYNISLKEVMQVLSHVVLEFPLQQMDSPLDSSRYCALLLPLLKAWSPVFRNYIKRAADHLEALAAIEDFFLEHEALGISMAKVLMAFYQLEILAEETILSWFSQRDTTDKGQQLRKNQQLQRFIQWLKEAEEESSEDD
翻译修饰 - Q13144 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| S20 | Phosphorylation | Uniprot | |
| S27 | Phosphorylation | Uniprot | |
| S51 | Phosphorylation | P48729 (CSNK1A1) | Uniprot |
| K61 | Ubiquitination | Uniprot | |
| K103 | Ubiquitination | Uniprot | |
| K108 | Ubiquitination | Uniprot | |
| K141 | Ubiquitination | Uniprot | |
| T182 | Phosphorylation | Uniprot | |
| K186 | Ubiquitination | Uniprot | |
| K217 | Ubiquitination | Uniprot | |
| Y319 | Phosphorylation | Uniprot | |
| K420 | Ubiquitination | Uniprot | |
| S447 | Phosphorylation | Uniprot | |
| S450 | Phosphorylation | Uniprot | |
| S466 | Phosphorylation | P48729 (CSNK1A1) | Uniprot |
| S469 | Phosphorylation | P48729 (CSNK1A1) | Uniprot |
| K481 | Ubiquitination | Uniprot | |
| Y483 | Phosphorylation | Uniprot | |
| K493 | Ubiquitination | Uniprot | |
| S525 | Phosphorylation | Uniprot | |
| S527 | Phosphorylation | Uniprot | |
| S529 | Phosphorylation | Uniprot | |
| S532 | Phosphorylation | Uniprot | |
| S535 | Phosphorylation | P49841 (GSK3B) | Uniprot |
| S540 | Phosphorylation | P49841 (GSK3B) , P49840 (GSK3A) | Uniprot |
| S544 | Phosphorylation | P49840 (GSK3A) , P49841 (GSK3B) | Uniprot |
| K565 | Ubiquitination | Uniprot | |
| Y583 | Phosphorylation | Uniprot | |
| S610 | Phosphorylation | Uniprot | |
| C618 | S-Nitrosylation | Uniprot | |
| K693 | Ubiquitination | Uniprot | |
| S717 | Phosphorylation | P68400 (CSNK2A1) , P19784 (CSNK2A2) | Uniprot |
| S718 | Phosphorylation | P68400 (CSNK2A1) , P19784 (CSNK2A2) | Uniprot |
研究背景
Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
Phosphorylated at Ser-544 by DYRK2; this is required for subsequent phosphorylation by GSK3B (By similarity). Phosphorylated on serine and threonine residues by GSK3B; phosphorylation inhibits its function.
Polyubiquitinated, probably by NEDD4.
Complex of five different subunits; alpha, beta, gamma, delta and epsilon. Interacts with RGS2.
Belongs to the eIF-2B gamma/epsilon subunits family.
研究领域
· Genetic Information Processing > Translation > RNA transport.
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