产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
展开/折叠
alpha pal; alpha palindromic binding protein; Alpha palindromic-binding protein; Alpha-pal; locus control region factor 1; NFE2 related factor 1; NRF-1; Nrf1; NRF1_HUMAN; Nuclear respiratory factor 1;
抗原和靶标
- Q16656 NRF1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEEHGVTQTEHMATIEAHAVAQQVQQVHVATYTEHSMLSADEDSPSSPEDTSYDDSDILNSTAADEVTAHLAAAGPVGMAAAAAVATGKKRKRPHVFESNPSIRKRQQTRLLRKLRATLDEYTTRVGQQAIVLCISPSKPNPVFKVFGAAPLENVVRKYKSMILEDLESALAEHAPAPQEVNSELPPLTIDGIPVSVDKMTQAQLRAFIPEMLKYSTGRGKPGWGKESCKPIWWPEDIPWANVRSDVRTEEQKQRVSWTQALRTIVKNCYKQHGREDLLYAFEDQQTQTQATATHSIAHLVPSQTVVQTFSNPDGTVSLIQVGTGATVATLADASELPTTVTVAQVNYSAVADGEVEQNWATLQGGEMTIQTTQASEATQAVASLAEAAVAASQEMQQGATVTMALNSEAAAHAVATLAEATLQGGGQIVLSGETAAAVGALTGVQDANGLVQIPVSMYQTVVTSLAQGNGPVQVAMAPVTTRISDSAVTMDGQAVEVVTLEQ
翻译修饰 - Q16656 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S39 | Phosphorylation | Uniprot | |
| S44 | Phosphorylation | Uniprot | |
| S46 | Phosphorylation | Uniprot | |
| S47 | Phosphorylation | Uniprot | |
| S52 | Phosphorylation | Uniprot | |
| T87 | Phosphorylation | Uniprot | |
| K92 | Ubiquitination | Uniprot | |
| S99 | Phosphorylation | Uniprot | |
| T109 | Phosphorylation | Uniprot | |
| T118 | Phosphorylation | Uniprot | |
| Y122 | Phosphorylation | Uniprot | |
| T123 | Phosphorylation | Uniprot | |
| S136 | Phosphorylation | Uniprot | |
| S138 | Phosphorylation | Uniprot | |
| K139 | Ubiquitination | Uniprot | |
| K214 | Ubiquitination | Uniprot | |
| K221 | Acetylation | Uniprot | |
| K226 | Acetylation | Uniprot | |
| T259 | Phosphorylation | Uniprot | |
| K267 | Ubiquitination | Uniprot |
研究背景
Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication.
Phosphorylation enhances DNA binding.
Nucleus.
Ubiquitously expressed with strongest expression in skeletal muscle.
Homodimer. Binds DNA as a dimer. Interacts with PPRC1.
Belongs to the NRF1/Ewg family.
研究领域
· Environmental Information Processing > Signal transduction > Apelin signaling pathway. (View pathway)
· Human Diseases > Neurodegenerative diseases > Huntington's disease.
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