产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
展开/折叠
Heme binding 23 kDa protein; MSP23; Natural killer cell-enhancing factor A; NKEF A; NKEF-A; NKEFA; OSF3; Osteoblast specific factor 3; PAG; Paga; PAGB; Peroxiredoxin-1; PRDX1; PRDX1_HUMAN; Proliferation associated gene A; Proliferation-associated gene protein; PRX1; PrxI; TDPX2; Thioredoxin peroxidase 2; Thioredoxin-dependent peroxide reductase 2;
抗原和靶标
- Q06830 PRDX1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSSGNAKIGHPAPNFKATAVMPDGQFKDISLSDYKGKYVVFFFYPLDFTFVCPTEIIAFSDRAEEFKKLNCQVIGASVDSHFCHLAWVNTPKKQGGLGPMNIPLVSDPKRTIAQDYGVLKADEGISFRGLFIIDDKGILRQITVNDLPVGRSVDETLRLVQAFQFTDKHGEVCPAGWKPGSDTIKPDVQKSKEYFSKQK
翻译修饰 - Q06830 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S2 | Acetylation | Uniprot | |
| K7 | Acetylation | Uniprot | |
| K7 | Sumoylation | Uniprot | |
| K7 | Ubiquitination | Uniprot | |
| K16 | Acetylation | Uniprot | |
| K16 | Methylation | Uniprot | |
| K16 | Sumoylation | Uniprot | |
| K16 | Ubiquitination | Uniprot | |
| T18 | Phosphorylation | Q13043 (STK4) | Uniprot |
| K27 | Acetylation | Uniprot | |
| K27 | Methylation | Uniprot | |
| K27 | Ubiquitination | Uniprot | |
| S30 | Phosphorylation | Uniprot | |
| S32 | Phosphorylation | Q96KB5 (PBK) | Uniprot |
| Y34 | Phosphorylation | Uniprot | |
| K35 | Acetylation | Uniprot | |
| K35 | Ubiquitination | Uniprot | |
| K37 | Acetylation | Uniprot | |
| K37 | Ubiquitination | Uniprot | |
| C52 | S-Nitrosylation | Uniprot | |
| K67 | Acetylation | Uniprot | |
| K67 | Sumoylation | Uniprot | |
| K68 | Ubiquitination | Uniprot | |
| S77 | Phosphorylation | Uniprot | |
| S80 | Phosphorylation | Uniprot | |
| T90 | Phosphorylation | P24941 (CDK2) , Q00534 (CDK6) , P06493 (CDK1) , P11802 (CDK4) , Q13043 (STK4) | Uniprot |
| K92 | Acetylation | Uniprot | |
| K93 | Acetylation | Uniprot | |
| K93 | Sumoylation | Uniprot | |
| K93 | Ubiquitination | Uniprot | |
| S106 | Phosphorylation | Uniprot | |
| K109 | Acetylation | Uniprot | |
| K109 | Ubiquitination | Uniprot | |
| T111 | Phosphorylation | Uniprot | |
| Y116 | Phosphorylation | Uniprot | |
| K120 | Ubiquitination | Uniprot | |
| S126 | Phosphorylation | Uniprot | |
| K136 | Acetylation | Uniprot | |
| K136 | Ubiquitination | Uniprot | |
| T143 | Phosphorylation | Uniprot | |
| R151 | Methylation | Uniprot | |
| S152 | Phosphorylation | Uniprot | |
| T156 | Phosphorylation | Uniprot | |
| R158 | Methylation | Uniprot | |
| T166 | Phosphorylation | Uniprot | |
| K168 | Acetylation | Uniprot | |
| K168 | Ubiquitination | Uniprot | |
| C173 | S-Nitrosylation | Uniprot | |
| K178 | Acetylation | Uniprot | |
| K178 | Methylation | Uniprot | |
| K178 | Ubiquitination | Uniprot | |
| S181 | Phosphorylation | Uniprot | |
| T183 | Phosphorylation | Q13043 (STK4) | Uniprot |
| K185 | Acetylation | Uniprot | |
| K185 | Sumoylation | Uniprot | |
| K185 | Ubiquitination | Uniprot | |
| K190 | Ubiquitination | Uniprot | |
| K192 | Sumoylation | Uniprot | |
| K192 | Ubiquitination | Uniprot | |
| Y194 | Phosphorylation | P06239 (LCK) | Uniprot |
| S196 | Phosphorylation | Uniprot | |
| K197 | Acetylation | Uniprot | |
| K197 | Ubiquitination | Uniprot |
研究背景
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity).
Phosphorylated on Thr-90 during the M-phase, which leads to a more than 80% decrease in enzymatic activity.
The enzyme can be inactivated by further oxidation of the cysteine sulfenic acid (C(P)-SOH) to sulphinic acid (C(P)-SO2H) instead of its condensation to a disulfide bond. It can be reactivated by forming a transient disulfide bond with sulfiredoxin SRXN1, which reduces the cysteine sulfinic acid in an ATP- and Mg-dependent manner.
Cytoplasm. Melanosome.
Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Homodimer; disulfide-linked, upon oxidation. 5 homodimers assemble to form a ring-like decamer. Interacts with GDPD5; forms a mixed-disulfide with GDPD5 (By similarity). Interacts with SESN1 and SESN2. Interacts with FAM107A.
Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
研究领域
· Cellular Processes > Transport and catabolism > Peroxisome. (View pathway)
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