产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
展开/折叠
C myb; C myb protein; Cmyb; MYB; Myb proto oncogene; V myb myeloblastosis viral oncogene homolog;
抗原和靶标
A synthesized peptide derived from human c-Myb, corresponding to a region within C-terminal amino acids.
- P10242 MYB_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MARRPRHSIYSSDEDDEDFEMCDHDYDGLLPKSGKRHLGKTRWTREEDEKLKKLVEQNGTDDWKVIANYLPNRTDVQCQHRWQKVLNPELIKGPWTKEEDQRVIELVQKYGPKRWSVIAKHLKGRIGKQCRERWHNHLNPEVKKTSWTEEEDRIIYQAHKRLGNRWAEIAKLLPGRTDNAIKNHWNSTMRRKVEQEGYLQESSKASQPAVATSFQKNSHLMGFAQAPPTAQLPATGQPTVNNDYSYYHISEAQNVSSHVPYPVALHVNIVNVPQPAAAAIQRHYNDEDPEKEKRIKELELLLMSTENELKGQQVLPTQNHTCSYPGWHSTTIADHTRPHGDSAPVSCLGEHHSTPSLPADPGSLPEESASPARCMIVHQGTILDNVKNLLEFAETLQFIDSFLNTSSNHENSDLEMPSLTSTPLIGHKLTVTTPFHRDQTVKTQKENTVFRTPAIKRSILESSPRTPTPFKHALAAQEIKYGPLKMLPQTPSHLVEDLQDVIKQESDESGIVAEFQENGPPLLKKIKQEVESPTDKSGNFFCSHHWEGDSLNTQLFTQTSPVADAPNILTSSVLMAPASEDEDNVLKAFTVPKNRSLASPLQPCSSTWEPASCGKMEEQMTSSSQARKYVNAFSARTLVM
翻译修饰 - P10242 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S11 | Phosphorylation | P68400 (CSNK2A1) | Uniprot |
| S12 | Phosphorylation | P68400 (CSNK2A1) | Uniprot |
| K53 | Ubiquitination | Uniprot | |
| Y69 | Phosphorylation | Uniprot | |
| K84 | Ubiquitination | Uniprot | |
| K92 | Ubiquitination | Uniprot | |
| K97 | Ubiquitination | Uniprot | |
| K109 | Ubiquitination | Uniprot | |
| K113 | Ubiquitination | Uniprot | |
| S116 | Phosphorylation | P17612 (PRKACA) | Uniprot |
| K120 | Ubiquitination | Uniprot | |
| C130 | S-Nitrosylation | Uniprot | |
| K143 | Sumoylation | Uniprot | |
| K143 | Ubiquitination | Uniprot | |
| K160 | Ubiquitination | Uniprot | |
| K171 | Ubiquitination | Uniprot | |
| K182 | Ubiquitination | Uniprot | |
| K192 | Ubiquitination | Uniprot | |
| K204 | Ubiquitination | Uniprot | |
| K291 | Ubiquitination | Uniprot | |
| K293 | Ubiquitination | Uniprot | |
| K296 | Ubiquitination | Uniprot | |
| T420 | Phosphorylation | Uniprot | |
| T433 | Phosphorylation | Uniprot | |
| K442 | Ubiquitination | Uniprot | |
| K445 | Acetylation | Uniprot | |
| K445 | Ubiquitination | Uniprot | |
| T452 | Phosphorylation | Uniprot | |
| R457 | Methylation | Uniprot | |
| S463 | Phosphorylation | Uniprot | |
| R465 | Methylation | Uniprot | |
| T466 | Phosphorylation | Uniprot | |
| T468 | Phosphorylation | Uniprot | |
| K471 | Acetylation | Uniprot | |
| K471 | Methylation | Uniprot | |
| K471 | Ubiquitination | Uniprot | |
| K480 | Acetylation | Uniprot | |
| K480 | Sumoylation | Uniprot | |
| K480 | Ubiquitination | Uniprot | |
| K485 | Acetylation | Uniprot | |
| K485 | Ubiquitination | Uniprot | |
| K503 | Sumoylation | Uniprot | |
| K527 | Sumoylation | Uniprot | |
| S532 | Phosphorylation | P27361 (MAPK3) | Uniprot |
| T534 | Phosphorylation | Uniprot | |
| K593 | Ubiquitination | Uniprot | |
| S599 | Phosphorylation | Uniprot | |
| K615 | Ubiquitination | Uniprot | |
| T621 | Phosphorylation | Uniprot | |
| S624 | Phosphorylation | Uniprot | |
| K628 | Ubiquitination | Uniprot |
研究背景
Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.
Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.
Phosphorylated by NLK on multiple sites, which induces proteasomal degradation.
Phosphorylated by HIPK1. This phosphorylation reduces MYB transcription factor activity but not MYB protein levels.
Nucleus.
Binds MYBBP1A. Interacts with HIPK2, MAF and NLK (By similarity). Binds to HIPK1.
Comprised of 3 domains; an N-terminal DNA-binding domain, a centrally located transcriptional activation domain and a C-terminal domain involved in transcriptional repression.
研究领域
· Environmental Information Processing > Signal transduction > PI3K-Akt signaling pathway. (View pathway)
· Human Diseases > Infectious diseases: Viral > HTLV-I infection.
限制条款
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