产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
展开/折叠
actinin 1 smooth muscle; Actinin alpha 1; actinin, alpha 1; ACTN 1; Actn1; ACTN1_HUMAN; Alpha Actinin 1; Alpha actinin cytoskeletal isoform; Alpha-actinin cytoskeletal isoform; Alpha-actinin-1; BDPLT15; F actin cross linking protein; F-actin cross-linking protein; FLJ40884; FLJ54432; Non muscle alpha actinin 1; Non-muscle alpha-actinin-1;
抗原和靶标
- P12814 ACTN1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDHYDSQQTNDYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDPQGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITMDELRRELPPDQAEYCIARMAPYTGPDSVPGALDYMSFSTALYGESDL
翻译修饰 - P12814 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| M1 | Acetylation | Uniprot | |
| Y4 | Phosphorylation | Uniprot | |
| S6 | Phosphorylation | Uniprot | |
| T9 | Phosphorylation | Uniprot | |
| Y12 | Phosphorylation | A0A059VC25 (FAK) , Q05397 (PTK2) | Uniprot |
| K31 | Ubiquitination | Uniprot | |
| K35 | Ubiquitination | Uniprot | |
| K47 | Ubiquitination | Uniprot | |
| T50 | Phosphorylation | Uniprot | |
| S73 | Phosphorylation | Uniprot | |
| K89 | Ubiquitination | Uniprot | |
| S91 | Phosphorylation | Uniprot | |
| K95 | Acetylation | Uniprot | |
| S102 | Phosphorylation | Uniprot | |
| K103 | Ubiquitination | Uniprot | |
| S109 | Phosphorylation | Uniprot | |
| T123 | Phosphorylation | Uniprot | |
| S140 | Phosphorylation | Uniprot | |
| T144 | Phosphorylation | Uniprot | |
| S145 | Phosphorylation | Uniprot | |
| C154 | S-Nitrosylation | Uniprot | |
| K162 | Ubiquitination | Uniprot | |
| S172 | Phosphorylation | Uniprot | |
| Y193 | Phosphorylation | Uniprot | |
| K195 | Acetylation | Uniprot | |
| K195 | Ubiquitination | Uniprot | |
| K198 | Acetylation | Uniprot | |
| K198 | Ubiquitination | Uniprot | |
| K214 | Ubiquitination | Uniprot | |
| Y215 | Phosphorylation | Uniprot | |
| K220 | Ubiquitination | Uniprot | |
| T230 | Phosphorylation | Uniprot | |
| Y241 | Phosphorylation | Uniprot | |
| S243 | Phosphorylation | Uniprot | |
| S244 | Phosphorylation | Uniprot | |
| Y246 | Phosphorylation | Uniprot | |
| S250 | Phosphorylation | Uniprot | |
| R261 | Methylation | Uniprot | |
| Y279 | Phosphorylation | Uniprot | |
| S284 | Phosphorylation | Uniprot | |
| R291 | Methylation | Uniprot | |
| Y319 | Phosphorylation | Uniprot | |
| K324 | Ubiquitination | Uniprot | |
| K327 | Ubiquitination | Uniprot | |
| K331 | Ubiquitination | Uniprot | |
| C332 | S-Nitrosylation | Uniprot | |
| T340 | Phosphorylation | Uniprot | |
| T343 | Phosphorylation | Uniprot | |
| S348 | Phosphorylation | Uniprot | |
| S356 | Phosphorylation | Uniprot | |
| S362 | Phosphorylation | Uniprot | |
| Y378 | Phosphorylation | Uniprot | |
| K398 | Acetylation | Uniprot | |
| K398 | Ubiquitination | Uniprot | |
| K402 | Ubiquitination | Uniprot | |
| S404 | Phosphorylation | Uniprot | |
| T410 | Phosphorylation | Uniprot | |
| K413 | Ubiquitination | Uniprot | |
| Y422 | Phosphorylation | Uniprot | |
| T426 | Phosphorylation | Uniprot | |
| S428 | Phosphorylation | Uniprot | |
| K431 | Ubiquitination | Uniprot | |
| K436 | Acetylation | Uniprot | |
| K436 | Ubiquitination | Uniprot | |
| S442 | Phosphorylation | Uniprot | |
| Y466 | Phosphorylation | Uniprot | |
| Y467 | Phosphorylation | Uniprot | |
| S471 | Phosphorylation | Uniprot | |
| K478 | Ubiquitination | Uniprot | |
| C480 | S-Nitrosylation | Uniprot | |
| K492 | Acetylation | Uniprot | |
| K492 | Ubiquitination | Uniprot | |
| K502 | Ubiquitination | Uniprot | |
| Y511 | Phosphorylation | Uniprot | |
| Y514 | Phosphorylation | Uniprot | |
| S576 | Phosphorylation | Uniprot | |
| Y582 | Phosphorylation | Uniprot | |
| K633 | Ubiquitination | Uniprot | |
| S669 | Phosphorylation | Uniprot | |
| Y674 | Phosphorylation | Uniprot | |
| K676 | Acetylation | Uniprot | |
| K676 | Ubiquitination | Uniprot | |
| S677 | Phosphorylation | Uniprot | |
| Y681 | Phosphorylation | Uniprot | |
| K684 | Ubiquitination | Uniprot | |
| Y708 | Phosphorylation | Uniprot | |
| T722 | Phosphorylation | Uniprot | |
| T727 | Phosphorylation | Uniprot | |
| T737 | Phosphorylation | Uniprot | |
| S744 | Phosphorylation | Uniprot | |
| S763 | Phosphorylation | Uniprot | |
| T765 | Phosphorylation | Uniprot | |
| S797 | Phosphorylation | Uniprot | |
| T820 | Phosphorylation | Uniprot | |
| T823 | Phosphorylation | Uniprot | |
| T825 | Phosphorylation | Uniprot | |
| S832 | Phosphorylation | Uniprot | |
| Y842 | Phosphorylation | Uniprot | |
| T844 | Phosphorylation | Uniprot | |
| Y859 | Phosphorylation | Uniprot | |
| Y887 | Phosphorylation | Uniprot | |
| S890 | Phosphorylation | Uniprot |
研究背景
F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.
Cytoplasm>Cytoskeleton. Cytoplasm>Myofibril>Sarcomere>Z line. Cell membrane. Cell junction. Cell projection>Ruffle.
Note: Colocalizes with MYOZ2 and PPP3CA at the Z-line of heart and skeletal muscle. Colocalizes with PSD in membrane ruffles and central reticular structures.
Homodimer; antiparallel. Interacts with MYOZ2, TTID and LPP. Interacts with DDN. Interacts with PSD. Interacts with MICALL2 (By similarity). Interacts with DNM2 and CTTN. Interacts with PDLIM1. Interacts with PDLIM2. Interacts with PDLIM4 (via PDZ domain) (By similarity).
Belongs to the alpha-actinin family.
研究领域
· Cellular Processes > Cellular community - eukaryotes > Focal adhesion. (View pathway)
· Cellular Processes > Cellular community - eukaryotes > Adherens junction. (View pathway)
· Cellular Processes > Cellular community - eukaryotes > Tight junction. (View pathway)
· Cellular Processes > Cell motility > Regulation of actin cytoskeleton. (View pathway)
· Human Diseases > Infectious diseases: Parasitic > Amoebiasis.
· Human Diseases > Cancers: Overview > Viral carcinogenesis.
· Human Diseases > Immune diseases > Systemic lupus erythematosus.
· Organismal Systems > Immune system > Leukocyte transendothelial migration. (View pathway)
限制条款
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