产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
展开/折叠
Dickkopf 1; Dickkopf 1 homolog; Dickkopf 1 like; Dickkopf homolog 1; Dickkopf like protein 1; Dickkopf related protein 1; Dickkopf WNT signaling pathway inhibitor 1; Dickkopf-1; Dickkopf-related protein 1; DKK 1; Dkk-1; Dkk1; DKK1_HUMAN; hDkk 1; hDkk-1; SK;
抗原和靶标
- O94907 DKK1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MMALGAAGATRVFVAMVAAALGGHPLLGVSATLNSVLNSNAIKNLPPPLGGAAGHPGSAVSAAPGILYPGGNKYQTIDNYQPYPCAEDEECGTDEYCASPTRGGDAGVQICLACRKRRKRCMRHAMCCPGNYCKNGICVSSDQNHFRGEIEETITESFGNDHSTLDGYSRRTTLSSKMYHTKGQEGSVCLRSSDCASGLCCARHFWSKICKPVLKEGQVCTKHRRKGSHGLEIFQRCYCGEGLSCRIQKDHHQASNSSRLHTCQRH
翻译修饰 - O94907 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S61 | O-Glycosylation | Uniprot | |
| Y132 | Phosphorylation | Uniprot | |
| S140 | Phosphorylation | Uniprot | |
| S141 | Phosphorylation | Uniprot | |
| T155 | O-Glycosylation | Uniprot | |
| S163 | O-Glycosylation | Uniprot | |
| T164 | O-Glycosylation | Uniprot | |
| S169 | O-Glycosylation | Uniprot | |
| T172 | O-Glycosylation | Uniprot | |
| T173 | O-Glycosylation | Uniprot | |
| T181 | O-Glycosylation | Uniprot | |
| T221 | Phosphorylation | Uniprot | |
| S255 | Phosphorylation | Uniprot | |
| N256 | N-Glycosylation | Uniprot | |
| S257 | Phosphorylation | Uniprot | |
| S258 | Phosphorylation | Uniprot | |
| T262 | Phosphorylation | Uniprot |
研究背景
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity (By similarity).
Secreted.
Placenta.
Interacts with LRP6. Interacts (via the C-termianl Cys-rich domain) with LRP5 (via beta-propeller regions 3 and 4); the interaction, enhanced by MESD and or KREMEN, antagonizes Wnt-mediated signaling. Forms a ternary complex with LRP6 and KREM1. Interacts with KREM1.
The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6.
Belongs to the dickkopf family.
研究领域
· Environmental Information Processing > Signal transduction > Wnt signaling pathway. (View pathway)
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