产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
展开/折叠
Actin binding protein; ALS18; Epididymis tissue protein Li 184a; OTTHUMP00000125244; PFN 1; Pfn; PFN1; PROF1_HUMAN; Profilin I; Profilin-1; Profilin1; ProfilinI;
抗原和靶标
A synthesized peptide derived from human Profilin 1.
- P07737 PROF1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAGWNAYIDNLMADGTCQDAAIVGYKDSPSVWAAVPGKTFVNITPAEVGVLVGKDRSSFYVNGLTLGGQKCSVIRDSLLQDGEFSMDLRTKSTGGAPTFNVTVTKTDKTLVLLMGKEGVHGGLINKKCYEMASHLRRSQY
翻译修饰 - P07737 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| Y7 | Phosphorylation | Uniprot | |
| T16 | Phosphorylation | Uniprot | |
| Y25 | Phosphorylation | Uniprot | |
| K26 | Ubiquitination | Uniprot | |
| S28 | Phosphorylation | Uniprot | |
| S30 | Phosphorylation | Uniprot | |
| K38 | Acetylation | Uniprot | |
| K38 | Ubiquitination | Uniprot | |
| T39 | Phosphorylation | Uniprot | |
| T44 | Phosphorylation | Uniprot | |
| K54 | Acetylation | Uniprot | |
| K54 | Methylation | Uniprot | |
| K54 | Ubiquitination | Uniprot | |
| R56 | Methylation | Uniprot | |
| S57 | Phosphorylation | Uniprot | |
| Y60 | Phosphorylation | Uniprot | |
| T65 | Phosphorylation | Uniprot | |
| K70 | Ubiquitination | Uniprot | |
| S72 | Phosphorylation | Uniprot | |
| S77 | Phosphorylation | Uniprot | |
| S85 | Phosphorylation | Uniprot | |
| T90 | Phosphorylation | Uniprot | |
| K91 | Acetylation | Uniprot | |
| K91 | Ubiquitination | Uniprot | |
| S92 | Phosphorylation | Uniprot | |
| T93 | Phosphorylation | Uniprot | |
| T98 | Phosphorylation | Uniprot | |
| T102 | Phosphorylation | Uniprot | |
| T104 | Phosphorylation | Uniprot | |
| K105 | Acetylation | Uniprot | |
| K105 | Ubiquitination | Uniprot | |
| T106 | Phosphorylation | Uniprot | |
| K108 | Acetylation | Uniprot | |
| K108 | Ubiquitination | Uniprot | |
| T109 | Phosphorylation | Uniprot | |
| K116 | Ubiquitination | Uniprot | |
| K126 | Acetylation | Uniprot | |
| K126 | Ubiquitination | Uniprot | |
| K127 | Ubiquitination | Uniprot | |
| C128 | S-Nitrosylation | Uniprot | |
| Y129 | Phosphorylation | P12931 (SRC) , P35968 (KDR) | Uniprot |
| S133 | Phosphorylation | Uniprot | |
| S138 | Phosphorylation | Q13464 (ROCK1) | Uniprot |
| Y140 | Phosphorylation | Uniprot |
研究背景
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR.
Phosphorylation at Ser-138 reduces its affinity for G-actin and blocks its interaction with HTT, reducing its ability to inhibit androgen receptor (AR) and HTT aggregation.
Cytoplasm>Cytoskeleton.
Expressed in epididymis (at protein level).
Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio. Found in a complex with XPO6, Ran, ACTB and PFN1. Interacts with VASP. Interacts with HTT.
Belongs to the profilin family.
研究领域
· Cellular Processes > Cell motility > Regulation of actin cytoskeleton. (View pathway)
· Environmental Information Processing > Signal transduction > Rap1 signaling pathway. (View pathway)
· Human Diseases > Infectious diseases: Bacterial > Shigellosis.
· Human Diseases > Infectious diseases: Bacterial > Salmonella infection.
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