产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
展开/折叠
2310009A18Rik; AI450277; EC 6.5.1.4; MGC102342; MGC94866; RNA 3' terminal phosphate cyclase; RNA 3-prime-terminal phosphate cyclase; RNA cyclase; RNA terminal phosphate cyclase domain 1; RNA terminal phosphate cyclase domain containing protein 1; RNA-3'-phosphate cyclase; RPC; RPC1; RTC domain containing protein 1; RTC1; RTCA; RTCD1;
抗原和靶标
- O00442 RTCA_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAGPRVEVDGSIMEGGGQILRVSTALSCLLGLPLRVQKIRAGRSTPGLRPQHLSGLEMIRDLCDGQLEGAEIGSTEITFTPEKIKGGIHTADTKTAGSVCLLMQVSMPCVLFAASPSELHLKGGTNAEMAPQIDYTVMVFKPIVEKFGFIFNCDIKTRGYYPKGGGEVIVRMSPVKQLNPINLTERGCVTKIYGRAFVAGVLPFKVAKDMAAAAVRCIRKEIRDLYVNIQPVQEPKDQAFGNGNGIIIIAETSTGCLFAGSSLGKRGVNADKVGIEAAEMLLANLRHGGTVDEYLQDQLIVFMALANGVSRIKTGPVTLHTQTAIHFAEQIAKAKFIVKKSEDEEDAAKDTYIIECQGIGMTNPNL
翻译修饰 - O00442 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S27 | Phosphorylation | Uniprot | |
| S44 | Phosphorylation | Uniprot | |
| K85 | Ubiquitination | Uniprot | |
| K156 | Ubiquitination | Uniprot | |
| K163 | Acetylation | Uniprot | |
| K163 | Ubiquitination | Uniprot | |
| S173 | Phosphorylation | Uniprot | |
| K176 | Ubiquitination | Uniprot | |
| T184 | Phosphorylation | Uniprot | |
| K191 | Ubiquitination | Uniprot | |
| K205 | Methylation | Uniprot | |
| K208 | Ubiquitination | Uniprot | |
| K272 | Ubiquitination | Uniprot | |
| T314 | Phosphorylation | Uniprot | |
| C356 | S-Nitrosylation | Uniprot |
研究背景
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Nucleus>Nucleoplasm.
Ubiquitous.
Monomer.
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
限制条款
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