产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
展开/折叠
1 phosphatidylinositol 3 phosphate 5 kinase; 1 phosphatidylinositol 4 phosphate 5 kinase; 1-phosphatidylinositol 3-phosphate 5-kinase; CFD; epididymis luminal protein 37; FAB1; FAB1, S. cerevisiae, homolog of; FYV1_HUMAN; FYVE finger containing phosphoinositide kinase; FYVE finger-containing phosphoinositide kinase; KIAA0981; MGC40423; p235; Phosphatidylinositol 3 phosphate 5 kinase type III; Phosphatidylinositol 3 phosphate/phosphatidylinositol 5 kinase type III; Phosphatidylinositol 3-phosphate 5-kinase; Phosphatidylinositol 3-phosphate 5-kinase type III; Phosphatidylinositol 4 phosphate 5 kinase type III; Phosphoinositide kinase, FYVE finger containing; PIKfyve; PIP5K; PIP5K3; PIPkin III; PIPkin-III; PtdIns(4)P 5 kinase; Type III PIP kinase; ZFYVE29; Zinc finger, FYVE domain containing 29;
抗原和靶标
A synthesized peptide derived from Human PIKFYVE.
- Q9Y2I7 FYV1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MATDDKTSPTLDSANDLPRSPTSPSHLTHFKPLTPDQDEPPFKSAYSSFVNLFRFNKERAEGGQGEQQPLSGSWTSPQLPSRTQSVRSPTPYKKQLNEELQRRSSALDTRRKAEPTFGGHDPRTAVQLRSLSTVLKRLKEIMEGKSQDSDLKQYWMPDSQCKECYDCSEKFTTFRRRHHCRLCGQIFCSRCCNQEIPGKFMGYTGDLRACTYCRKIALSYAHSTDSNSIGEDLNALSDSACSVSVLDPSEPRTPVGSRKASRNIFLEDDLAWQSLIHPDSSNTPLSTRLVSVQEDAGKSPARNRSASITNLSLDRSGSPMVPSYETSVSPQANRTYVRTETTEDERKILLDSVQLKDLWKKICHHSSGMEFQDHRYWLRTHPNCIVGKELVNWLIRNGHIATRAQAIAIGQAMVDGRWLDCVSHHDQLFRDEYALYRPLQSTEFSETPSPDSDSVNSVEGHSEPSWFKDIKFDDSDTEQIAEEGDDNLANSASPSKRTSVSSFQSTVDSDSAASISLNVELDNVNFHIKKPSKYPHVPPHPADQKEYLISDTGGQQLSISDAFIKESLFNRRVEEKSKELPFTPLGWHHNNLELLREENGEKQAMERLLSANHNHMMALLQQLLHSDSLSSSWRDIIVSLVCQVVQTVRPDVKNQDDDMDIRQFVHIKKIPGGKKFDSVVVNGFVCTKNIAHKKMSSCIKNPKILLLKCSIEYLYREETKFTCIDPIVLQEREFLKNYVQRIVDVRPTLVLVEKTVSRIAQDMLLEHGITLVINVKSQVLERISRMTQGDLVMSMDQLLTKPHLGTCHKFYMQIFQLPNEQTKTLMFFEGCPQHLGCTIKLRGGSDYELARVKEILIFMICVAYHSQLEISFLMDEFAMPPTLMQNPSFHSLIEGRGHEGAVQEQYGGGSIPWDPDIPPESLPCDDSSLLELRIVFEKGEQENKNLPQAVASVKHQEHSTTACPAGLPCAFFAPVPESLLPLPVDDQQDALGSEQPETLQQTVVLQDPKSQIRAFRDPLQDDTGLYVTEEVTSSEDKRKTYSLAFKQELKDVILCISPVITFREPFLLTEKGMRCSTRDYFAEQVYWSPLLNKEFKEMENRRKKQLLRDLSGLQGMNGSIQAKSIQVLPSHELVSTRIAEHLGDSQSLGRMLADYRARGGRIQPKNSDPFAHSKDASSTSSGQSGSKNEGDEERGLILSDAVWSTKVDCLNPINHQRLCVLFSSSSAQSSNAPSACVSPWIVTMEFYGKNDLTLGIFLERYCFRPSYQCPSMFCDTPMVHHIRRFVHGQGCVQIILKELDSPVPGYQHTILTYSWCRICKQVTPVVALSNESWSMSFAKYLELRFYGHQYTRRANAEPCGHSIHHDYHQYFSYNQMVASFSYSPIRLLEVCVPLPKIFIKRQAPLKVSLLQDLKDFFQKVSQVYVAIDERLASLKTDTFSKTREEKMEDIFAQKEMEEGEFKNWIEKMQARLMSSSVDTPQQLQSVFESLIAKKQSLCEVLQAWNNRLQDLFQQEKGRKRPSVPPSPGRLRQGEESKISAMDASPRNISPGLQNGEKEDRFLTTLSSQSSTSSTHLQLPTPPEVMSEQSVGGPPELDTASSSEDVFDGHLLGSTDSQVKEKSTMKAIFANLLPGNSYNPIPFPFDPDKHYLMYEHERVPIAVCEKEPSSIIAFALSCKEYRNALEELSKATQWNSAEEGLPTNSTSDSRPKSSSPIRLPEMSGGQTNRTTETEPQPTKKASGMLSFFRGTAGKSPDLSSQKRETLRGADSAYYQVGQTGKEGTENQGVEPQDEVDGGDTQKKQLINPHVELQFSDANAKFYCRLYYAGEFHKMREVILDSSEEDFIRSLSHSSPWQARGGKSGAAFYATEDDRFILKQMPRLEVQSFLDFAPHYFNYITNAVQQKRPTALAKILGVYRIGYKNSQNNTEKKLDLLVMENLFYGRKMAQVFDLKGSLRNRNVKTDTGKESCDVVLLDENLLKMVRDNPLYIRSHSKAVLRTSIHSDSHFLSSHLIIDYSLLVGRDDTSNELVVGIIDYIRTFTWDKKLEMVVKSTGILGGQGKMPTVVSPELYRTRFCEAMDKYFLMVPDHWTGLGLNC
翻译修饰 - Q9Y2I7 作为底物
Site | PTM Type | Enzyme | Source |
---|---|---|---|
A2 | Acetylation | Uniprot | |
T3 | Phosphorylation | Uniprot | |
T7 | Phosphorylation | Uniprot | |
S20 | Phosphorylation | Uniprot | |
T22 | Phosphorylation | Uniprot | |
S23 | Phosphorylation | Uniprot | |
T34 | Phosphorylation | Uniprot | |
K43 | Methylation | Uniprot | |
S44 | Phosphorylation | Uniprot | |
Y46 | Phosphorylation | Uniprot | |
S48 | Phosphorylation | Uniprot | |
S76 | Phosphorylation | Uniprot | |
T83 | Phosphorylation | Uniprot | |
S88 | Phosphorylation | Uniprot | |
T90 | Phosphorylation | Uniprot | |
Y92 | Phosphorylation | Uniprot | |
K94 | Ubiquitination | Uniprot | |
S104 | Phosphorylation | Uniprot | |
S105 | Phosphorylation | Uniprot | |
T109 | Phosphorylation | Uniprot | |
K112 | Ubiquitination | Uniprot | |
S132 | Phosphorylation | Uniprot | |
T133 | Phosphorylation | Uniprot | |
K136 | Ubiquitination | Uniprot | |
K139 | Ubiquitination | Uniprot | |
K152 | Ubiquitination | Uniprot | |
Y154 | Phosphorylation | Uniprot | |
T173 | Phosphorylation | Uniprot | |
T253 | Phosphorylation | Uniprot | |
S261 | Phosphorylation | Uniprot | |
S274 | Phosphorylation | Uniprot | |
S291 | Phosphorylation | Uniprot | |
K298 | Ubiquitination | Uniprot | |
S299 | Phosphorylation | Uniprot | |
S305 | Phosphorylation | Uniprot | |
S307 | Phosphorylation | P54646 (PRKAA2) , P31749 (AKT1) | Uniprot |
T309 | Phosphorylation | Uniprot | |
S312 | Phosphorylation | Uniprot | |
S316 | Phosphorylation | Uniprot | |
S318 | Phosphorylation | P31749 (AKT1) , O00141 (SGK1) | Uniprot |
Y324 | Phosphorylation | Uniprot | |
T326 | Phosphorylation | Uniprot | |
S327 | Phosphorylation | Uniprot | |
S329 | Phosphorylation | Uniprot | |
T335 | Phosphorylation | Uniprot | |
T339 | Phosphorylation | Uniprot | |
T341 | Phosphorylation | Uniprot | |
T342 | Phosphorylation | Uniprot | |
K347 | Ubiquitination | Uniprot | |
S352 | Phosphorylation | Uniprot | |
K356 | Ubiquitination | Uniprot | |
K361 | Ubiquitination | Uniprot | |
S366 | Phosphorylation | Uniprot | |
S367 | Phosphorylation | Uniprot | |
S449 | Phosphorylation | Uniprot | |
S452 | Phosphorylation | Uniprot | |
S454 | Phosphorylation | Uniprot | |
S457 | Phosphorylation | Uniprot | |
S475 | Phosphorylation | Uniprot | |
T477 | Phosphorylation | Uniprot | |
S491 | Phosphorylation | Uniprot | |
S493 | Phosphorylation | Uniprot | |
K565 | Ubiquitination | Uniprot | |
K578 | Ubiquitination | Uniprot | |
T583 | Phosphorylation | Uniprot | |
K669 | Acetylation | Uniprot | |
K675 | Acetylation | Uniprot | |
K720 | Ubiquitination | Uniprot | |
K736 | Ubiquitination | Uniprot | |
K754 | Ubiquitination | Uniprot | |
T822 | Phosphorylation | Uniprot | |
S845 | Phosphorylation | Uniprot | |
S888 | Phosphorylation | Uniprot | |
K938 | Ubiquitination | Uniprot | |
K944 | Ubiquitination | Uniprot | |
K1046 | Ubiquitination | Uniprot | |
S1111 | Phosphorylation | Uniprot | |
S1124 | Phosphorylation | Uniprot | |
Y1155 | Phosphorylation | Uniprot | |
K1165 | Ubiquitination | Uniprot | |
S1167 | Phosphorylation | Uniprot | |
S1177 | Phosphorylation | Uniprot | |
K1206 | Ubiquitination | Uniprot | |
S1301 | Phosphorylation | Uniprot | |
T1312 | Phosphorylation | Uniprot | |
Y1350 | Phosphorylation | Uniprot | |
K1414 | Ubiquitination | Uniprot | |
K1435 | Ubiquitination | Uniprot | |
T1436 | Phosphorylation | Uniprot | |
S1440 | Phosphorylation | Uniprot | |
K1441 | Ubiquitination | Uniprot | |
K1446 | Ubiquitination | Uniprot | |
S1474 | Phosphorylation | Uniprot | |
S1475 | Phosphorylation | Uniprot | |
T1479 | Phosphorylation | Uniprot | |
S1489 | Phosphorylation | Uniprot | |
S1496 | Phosphorylation | Uniprot | |
K1516 | Ubiquitination | Uniprot | |
S1522 | Phosphorylation | Uniprot | |
S1526 | Phosphorylation | Uniprot | |
S1544 | Phosphorylation | Uniprot | |
S1549 | Phosphorylation | Uniprot | |
K1689 | Ubiquitination | Uniprot | |
S1712 | Phosphorylation | Uniprot | |
S1714 | Phosphorylation | Uniprot | |
S1741 | Phosphorylation | Uniprot | |
S1754 | Phosphorylation | Uniprot | |
K1761 | Ubiquitination | Uniprot | |
T1764 | Phosphorylation | Uniprot | |
S1770 | Phosphorylation | Uniprot | |
Y1772 | Phosphorylation | Uniprot | |
Y1773 | Phosphorylation | Uniprot | |
K1832 | Ubiquitination | Uniprot | |
K1861 | Ubiquitination | Uniprot | |
K1953 | Ubiquitination | Uniprot | |
K1967 | Ubiquitination | Uniprot | |
T2026 | Phosphorylation | Uniprot | |
Y2037 | Phosphorylation | Uniprot | |
K2062 | Ubiquitination | Uniprot | |
S2068 | Phosphorylation | Uniprot |
研究背景
The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. Plays a role in the biogenesis of endosome carrier vesicles (ECV)/ multivesicular bodies (MVB) transport intermediates from early endosomes.
Phosphorylated in response to insulin at Ser-318 in a protein kinase B (PKB)-dependent manner.
Endosome membrane.
Note: Mainly associated with membranes of the late endocytic pathway.
Component of the PI(3,5)P2 regulatory complex/PAS complex, at least composed of PIKFYVE, FIG4 and VAC14. VAC14 nucleates the assembly of the complex and serves as a scaffold.
研究领域
· Cellular Processes > Transport and catabolism > Phagosome. (View pathway)
· Cellular Processes > Cell motility > Regulation of actin cytoskeleton. (View pathway)
· Environmental Information Processing > Signal transduction > Phosphatidylinositol signaling system.
· Metabolism > Carbohydrate metabolism > Inositol phosphate metabolism.
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