产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
展开/折叠
ACO 1; ACO1; ACOC_HUMAN; Aconitase 1 soluble; Aconitase; Aconitase1; Aconitate hydratase; ACONS; Citrate hydro lyase; Citrate hydro-lyase; Cytoplasmic aconitate hydratase; Ferritin repressor protein; IRE BP 1; IRE-BP 1; IREB 1; IREB1; IREBP; IREBP1; Iron regulatory protein 1; Iron responsive element binding protein 1; Iron-responsive element-binding protein 1; IRP 1; IRP1; OTTHUMP00000045233;
抗原和靶标
A synthesized peptide derived from human IREB1.
- P21399 ACOC_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSNPFAHLAEPLDPVQPGKKFFNLNKLEDSRYGRLPFSIRVLLEAAIRNCDEFLVKKQDIENILHWNVTQHKNIEVPFKPARVILQDFTGVPAVVDFAAMRDAVKKLGGDPEKINPVCPADLVIDHSIQVDFNRRADSLQKNQDLEFERNRERFEFLKWGSQAFHNMRIIPPGSGIIHQVNLEYLARVVFDQDGYYYPDSLVGTDSHTTMIDGLGILGWGVGGIEAEAVMLGQPISMVLPQVIGYRLMGKPHPLVTSTDIVLTITKHLRQVGVVGKFVEFFGPGVAQLSIADRATIANMCPEYGATAAFFPVDEVSITYLVQTGRDEEKLKYIKKYLQAVGMFRDFNDPSQDPDFTQVVELDLKTVVPCCSGPKRPQDKVAVSDMKKDFESCLGAKQGFKGFQVAPEHHNDHKTFIYDNTEFTLAHGSVVIAAITSCTNTSNPSVMLGAGLLAKKAVDAGLNVMPYIKTSLSPGSGVVTYYLQESGVMPYLSQLGFDVVGYGCMTCIGNSGPLPEPVVEAITQGDLVAVGVLSGNRNFEGRVHPNTRANYLASPPLVIAYAIAGTIRIDFEKEPLGVNAKGQQVFLKDIWPTRDEIQAVERQYVIPGMFKEVYQKIETVNESWNALATPSDKLFFWNSKSTYIKSPPFFENLTLDLQPPKSIVDAYVLLNLGDSVTTDHISPAGNIARNSPAARYLTNRGLTPREFNSYGSRRGNDAVMARGTFANIRLLNRFLNKQAPQTIHLPSGEILDVFDAAERYQQAGLPLIVLAGKEYGAGSSRDWAAKGPFLLGIKAVLAESYERIHRSNLVGMGVIPLEYLPGENADALGLTGQERYTIIIPENLKPQMKVQVKLDTGKTFQAVMRFDTDVELTYFLNGGILNYMIRKMAK
翻译修饰 - P21399 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K26 | Ubiquitination | Uniprot | |
| S30 | Phosphorylation | Uniprot | |
| K79 | Ubiquitination | Uniprot | |
| K105 | Ubiquitination | Uniprot | |
| K106 | Ubiquitination | Uniprot | |
| S138 | Phosphorylation | P17252 (PRKCA) | Uniprot |
| K141 | Ubiquitination | Uniprot | |
| K158 | Ubiquitination | Uniprot | |
| Y184 | Phosphorylation | Uniprot | |
| K250 | Ubiquitination | Uniprot | |
| T258 | Phosphorylation | Uniprot | |
| T318 | Phosphorylation | Uniprot | |
| K335 | Ubiquitination | Uniprot | |
| Y336 | Phosphorylation | Uniprot | |
| S383 | Phosphorylation | Uniprot | |
| K386 | Ubiquitination | Uniprot | |
| K387 | Ubiquitination | Uniprot | |
| K396 | Ubiquitination | Uniprot | |
| K400 | Ubiquitination | Uniprot | |
| K455 | Ubiquitination | Uniprot | |
| Y466 | Phosphorylation | Uniprot | |
| S533 | Phosphorylation | Uniprot | |
| K572 | Ubiquitination | Uniprot | |
| K580 | Ubiquitination | Uniprot | |
| K587 | Ubiquitination | Uniprot | |
| K610 | Ubiquitination | Uniprot | |
| K615 | Ubiquitination | Uniprot | |
| S622 | Phosphorylation | Uniprot | |
| T628 | Phosphorylation | Uniprot | |
| K632 | Ubiquitination | Uniprot | |
| S638 | Phosphorylation | Uniprot | |
| K639 | Ubiquitination | Uniprot | |
| K644 | Ubiquitination | Uniprot | |
| S645 | Phosphorylation | Uniprot | |
| S711 | Phosphorylation | P17252 (PRKCA) | Uniprot |
| R713 | Methylation | Uniprot | |
| R721 | Methylation | Uniprot | |
| K736 | Ubiquitination | Uniprot | |
| K772 | Ubiquitination | Uniprot | |
| K785 | Ubiquitination | Uniprot | |
| S799 | Phosphorylation | Uniprot | |
| Y800 | Phosphorylation | Uniprot | |
| S806 | Phosphorylation | Uniprot | |
| K844 | Ubiquitination | Uniprot | |
| K852 | Ubiquitination | Uniprot | |
| K857 | Ubiquitination | Uniprot |
研究背景
Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding.
Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.
Cytoplasm.
Interacts (when associated with the 4Fe-4S) with FBXL5. Interacts with frataxin(81-210).
Belongs to the aconitase/IPM isomerase family.
研究领域
· Metabolism > Carbohydrate metabolism > Citrate cycle (TCA cycle).
· Metabolism > Carbohydrate metabolism > Glyoxylate and dicarboxylate metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
· Metabolism > Global and overview maps > Carbon metabolism.
· Metabolism > Global and overview maps > 2-Oxocarboxylic acid metabolism.
· Metabolism > Global and overview maps > Biosynthesis of amino acids.
限制条款
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