产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
展开/折叠
CAL; CFTR associated ligand; CFTR-associated ligand; dJ94G16.2; dJ94G16.2 PIST; FIG; Fused in glioblastoma; Golgi associated PDZ and coiled coil motif containing; Golgi associated PDZ and coiled coil motif containing protein; Golgi-associated PDZ and coiled-coil motif-containing protein; GOPC 1; GOPC; GOPC_HUMAN; GOPC1; OTTHUMP00000040403; PDZ protein interacting specifically with TC 10; PDZ protein interacting specifically with TC10; PDZ/coiled coil domain binding partner for the rho family GTPase TC 10; PDZ/coiled coil domain binding partner for the rho family GTPase TC10; PIST; Protein interacting specifically with Tc 10; Protein interacting specifically with Tc10;
抗原和靶标
- Q9HD26 GOPC_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSAGGPCPAAAGGGPGGASCSVGAPGGVSMFRWLEVLEKEFDKAFVDVDLLLGEIDPDQADITYEGRQKMTSLSSCFAQLCHKAQSVSQINHKLEAQLVDLKSELTETQAEKVVLEKEVHDQLLQLHSIQLQLHAKTGQSADSGTIKAKLSGPSVEELERELEANKKEKMKEAQLEAEVKLLRKENEALRRHIAVLQAEVYGARLAAKYLDKELAGRVQQIQLLGRDMKGPAHDKLWNQLEAEIHLHRHKTVIRACRGRNDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQRGEIEFEVVYVAPEVDSDDENVEYEDESGHRYRLYLDELEGGGNPGASCKDTSGEIKVLQGFNKKAVTDTHENGDLGTASETPLDDGASKLDDLHTLYHKKSY
翻译修饰 - Q9HD26 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S2 | Acetylation | Uniprot | |
| S2 | Phosphorylation | Uniprot | |
| K39 | Ubiquitination | Uniprot | |
| S86 | Phosphorylation | Uniprot | |
| K93 | Acetylation | Uniprot | |
| K93 | Ubiquitination | Uniprot | |
| K102 | Sumoylation | Uniprot | |
| K102 | Ubiquitination | Uniprot | |
| K112 | Ubiquitination | Uniprot | |
| K136 | Ubiquitination | Uniprot | |
| K147 | Ubiquitination | Uniprot | |
| S151 | Phosphorylation | Uniprot | |
| K171 | Ubiquitination | Uniprot | |
| K180 | Ubiquitination | Uniprot | |
| K208 | Ubiquitination | Uniprot | |
| K212 | Ubiquitination | Uniprot | |
| S276 | Phosphorylation | Uniprot | |
| K278 | Ubiquitination | Uniprot | |
| K279 | Ubiquitination | Uniprot | |
| S280 | Phosphorylation | Uniprot | |
| S302 | Phosphorylation | Uniprot | |
| K350 | Ubiquitination | Uniprot | |
| Y369 | Phosphorylation | Uniprot | |
| S376 | Phosphorylation | Uniprot | |
| Y383 | Phosphorylation | Uniprot | |
| S407 | Phosphorylation | Uniprot | |
| K409 | Ubiquitination | Uniprot | |
| T411 | Phosphorylation | Uniprot | |
| S412 | Phosphorylation | Uniprot | |
| K416 | Sumoylation | Uniprot | |
| K416 | Ubiquitination | Uniprot | |
| K423 | Ubiquitination | Uniprot | |
| T441 | Phosphorylation | Uniprot | |
| T455 | Phosphorylation | Uniprot | |
| Y457 | Phosphorylation | Uniprot | |
| K459 | Ubiquitination | Uniprot | |
| S461 | Phosphorylation | Uniprot | |
| Y462 | Phosphorylation | Uniprot |
研究背景
Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes.
Cytoplasm. Golgi apparatus membrane>Peripheral membrane protein. Golgi apparatus>trans-Golgi network membrane>Peripheral membrane protein. Cell junction>Synapse. Cell junction>Synapse>Postsynaptic density. Cell projection>Dendrite.
Note: Enriched in synaptosomal and postsynaptic densities (PSD) fractions. Expressed in cell bodies and dendrites of Purkinje cells. Localized at the trans-Golgi network (TGN) of spermatids and the medulla of round spermatides.
Ubiquitously expressed.
Homooligomer. Interacts with FZD5, FZD8, GRID2, BECN1, CSPG5 and CLCN3. May interact with CACNG2 (By similarity). Interacts with STX6, CFTR, ASIC3, GOLGA3, NLGN1 and RHOQ.
The PDZ domain mediates interactions with FZD5, FZD8, ASIC3, GRID2, CLCN3 (By similarity). Mediates also interaction with CFTR and ADRB1.
The coiled-coil region probably mediates association to membranes, targeting to the Golgi, and interactions with GOLGA3, and STX6. May also mediate interaction with RHOQ (By similarity).
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