产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
展开/折叠
2310066P17Rik; C20orf34; C42; CDK5 activator binding protein C42; CDK5 activator binding protein C42 like; CDK5 regulatory subunit associated protein 1; CDK5RAP1.3; CDK5RAP1.4; CGI 05; HSPC167; OTTMUSP00000016976; RP23-154J12.6; RP5-1187J4.1;
抗原和靶标
Widely expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
- Q96SZ6 CK5P1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MHPLQCVLQVQRSLGWGPLASVSWLSLRMCRAHSSLSSTMCPSPERQEDGARKDFSSRLAAGPTFQHFLKSASAPQEKLSSEVEDPPPYLMMDELLGRQRKVYLETYGCQMNVNDTEIAWSILQKSGYLRTSNLQEADVILLVTCSIREKAEQTIWNRLHQLKALKTRRPRSRVPLRIGILGCMAERLKEEILNREKMVDILAGPDAYRDLPRLLAVAESGQQAANVLLSLDETYADVMPVQTSASATSAFVSIMRGCDNMCSYCIVPFTRGRERSRPIASILEEVKKLSEQVFLPPRPPKVLGLQGLKEVTLLGQNVNSFRDNSEVQFNSAVPTNLSRGFTTNYKTKQGGLRFAHLLDQVSRVDPEMRIRFTSPHPKDFPDEVLQLIHERDNICKQIHLPAQSGSSRVLEAMRRGYSREAYVELVHHIRESIPGVSLSSDFIAGFCGETEEDHVQTVSLLREVQYNMGFLFAYSMRQKTRAYHRLKDDVPEEVKLRRLEELITIFREEATKANQTSVGCTQLVLVEGLSKRSATDLCGRNDGNLKVIFPDAEMEDVNNPGLRVRAQPGDYVLVKITSASSQTLRGHVLCRTTLRDSSAYC
翻译修饰 - Q96SZ6 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S37 | Phosphorylation | Uniprot | |
| K70 | Ubiquitination | Uniprot | |
| K78 | Ubiquitination | Uniprot | |
| K163 | Ubiquitination | Uniprot | |
| K189 | Ubiquitination | Uniprot | |
| K197 | Ubiquitination | Uniprot | |
| K287 | Ubiquitination | Uniprot | |
| R298 | Methylation | Uniprot | |
| K346 | Ubiquitination | Uniprot | |
| K378 | Ubiquitination | Uniprot | |
| K396 | Ubiquitination | Uniprot | |
| S406 | Phosphorylation | Uniprot | |
| Y422 | Phosphorylation | Uniprot | |
| Y483 | Phosphorylation | Uniprot | |
| K487 | Ubiquitination | Uniprot | |
| K495 | Ubiquitination | Uniprot | |
| K531 | Ubiquitination | Uniprot | |
| K546 | Acetylation | Uniprot | |
| K546 | Ubiquitination | Uniprot | |
| T583 | Phosphorylation | Uniprot |
研究背景
Specifically inhibits CDK5 activation by CDK5R1.
Widely expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Interacts with CDK5R1 (p35 form). CDK5RAP1, CDK5RAP2 and CDK5RAP3 show competitive binding to CDK5R1. Forms a complex with CDK5R1 and CDK5.
Belongs to the methylthiotransferase family. MiaB subfamily.
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