产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
展开/折叠
CK 2e; Cytokeratin-2e; Epithelial keratin-2e; K2e; Keratin type II cytoskeletal 2 epidermal; Keratin-2 epidermis; KRT2; KRT2A; KRT2E; Type-II keratin Kb2;
抗原和靶标
A synthesized peptide derived from human Cytokeratin 2e, corresponding to a region within N-terminal amino acids.
Expressed in the upper spinous and granular suprabasal layers of normal adult epidermal tissues from most body sites including thigh, breast nipple, foot sole, penile shaft and axilla. Not present in foreskin, squamous metaplasias and carcinomas. Expression in hypertrophic and keloid scars begins in the deepest suprabasal layer. Weakly expressed in normal gingiva and tongue, however expression is induced in benign keratoses of lingual mucosa and in mild-to-moderate oral dysplasia with orthokeratinization.
- P35908 K22E_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSCQISCKSRGRGGGGGGFRGFSSGSAVVSGGSRRSTSSFSCLSRHGGGGGGFGGGGFGSRSLVGLGGTKSISISVAGGGGGFGAAGGFGGRGGGFGGGSSFGGGSGFSGGGFGGGGFGGGRFGGFGGPGGVGGLGGPGGFGPGGYPGGIHEVSVNQSLLQPLNVKVDPEIQNVKAQEREQIKTLNNKFASFIDKVRFLEQQNQVLQTKWELLQQMNVGTRPINLEPIFQGYIDSLKRYLDGLTAERTSQNSELNNMQDLVEDYKKKYEDEINKRTAAENDFVTLKKDVDNAYMIKVELQSKVDLLNQEIEFLKVLYDAEISQIHQSVTDTNVILSMDNSRNLDLDSIIAEVKAQYEEIAQRSKEEAEALYHSKYEELQVTVGRHGDSLKEIKIEISELNRVIQRLQGEIAHVKKQCKNVQDAIADAEQRGEHALKDARNKLNDLEEALQQAKEDLARLLRDYQELMNVKLALDVEIATYRKLLEGEECRMSGDLSSNVTVSVTSSTISSNVASKAAFGGSGGRGSSSGGGYSSGSSSYGSGGRQSGSRGGSGGGGSISGGGYGSGGGSGGRYGSGGGSKGGSISGGGYGSGGGKHSSGGGSRGGSSSGGGYGSGGGGSSSVKGSSGEAFGSSVTFSFR
翻译修饰 - P35908 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S62 | Phosphorylation | Uniprot | |
| S75 | Phosphorylation | Uniprot | |
| K183 | Ubiquitination | Uniprot | |
| T184 | Phosphorylation | Uniprot | |
| K188 | Acetylation | Uniprot | |
| K188 | Methylation | Uniprot | |
| K188 | Sumoylation | Uniprot | |
| K188 | Ubiquitination | Uniprot | |
| S191 | Phosphorylation | Uniprot | |
| K195 | Acetylation | Uniprot | |
| K195 | Ubiquitination | Uniprot | |
| Y264 | Phosphorylation | Uniprot | |
| K265 | Acetylation | Uniprot | |
| K267 | Ubiquitination | Uniprot | |
| S347 | Phosphorylation | Uniprot | |
| Y356 | Phosphorylation | Uniprot | |
| R490 | Methylation | Uniprot | |
| R524 | Methylation | Uniprot | |
| S526 | Phosphorylation | Uniprot | |
| S527 | Phosphorylation | Uniprot | |
| S528 | Phosphorylation | Uniprot | |
| S536 | Phosphorylation | Uniprot | |
| S546 | Phosphorylation | Uniprot | |
| S548 | Phosphorylation | Uniprot | |
| S557 | Phosphorylation | Uniprot | |
| Y563 | Phosphorylation | Uniprot | |
| Y573 | Phosphorylation | Uniprot | |
| S579 | Phosphorylation | Uniprot | |
| S597 | Phosphorylation | Uniprot | |
| S598 | Phosphorylation | Uniprot | |
| S602 | Phosphorylation | Uniprot | |
| S606 | Phosphorylation | Uniprot | |
| S607 | Phosphorylation | Uniprot | |
| S608 | Phosphorylation | Uniprot | |
| S614 | Phosphorylation | Uniprot | |
| S620 | Phosphorylation | Uniprot | |
| S621 | Phosphorylation | Uniprot | |
| T635 | Phosphorylation | Uniprot | |
| S637 | Phosphorylation | Uniprot |
研究背景
Probably contributes to terminal cornification. Associated with keratinocyte activation, proliferation and keratinization. Plays a role in the establishment of the epidermal barrier on plantar skin (By similarity).
Expressed in the upper spinous and granular suprabasal layers of normal adult epidermal tissues from most body sites including thigh, breast nipple, foot sole, penile shaft and axilla. Not present in foreskin, squamous metaplasias and carcinomas. Expression in hypertrophic and keloid scars begins in the deepest suprabasal layer. Weakly expressed in normal gingiva and tongue, however expression is induced in benign keratoses of lingual mucosa and in mild-to-moderate oral dysplasia with orthokeratinization.
Heterotetramer of two type I and two type II keratins. Associates with KRT10 (By similarity).
Belongs to the intermediate filament family.
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