产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
展开/折叠
Acyl CoA dehydrogenase 9; Acyl Coenzyme A dehydrogenase family, member 9; acyl-CoA dehydrogenase family member 9, mitochondrial; FLJ23533; MGC14452; NPD002; Very long chain acyl CoA dehydrogenase VLCAD;
抗原和靶标
Ubiquitously expressed in most normal human tissues and cancer cell lines with high level of expression in heart, skeletal muscles, brain, kidney and liver (PubMed:12359260). In the cerebellum uniquely expressed in the granular layer (at protein level) (PubMed:21237683).
- Q9H845 ACAD9_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSGCGLFLRTTAAARACRGLVVSTANRRLLRTSPPVRAFAKELFLGKIKKKEVFPFPEVSQDELNEINQFLGPVEKFFTEEVDSRKIDQEGKIPDETLEKLKSLGLFGLQVPEEYGGLGFSNTMYSRLGEIISMDGSITVTLAAHQAIGLKGIILAGTEEQKAKYLPKLASGEHIAAFCLTEPASGSDAASIRSRATLSEDKKHYILNGSKVWITNGGLANIFTVFAKTEVVDSDGSVKDKITAFIVERDFGGVTNGKPEDKLGIRGSNTCEVHFENTKIPVENILGEVGDGFKVAMNILNSGRFSMGSVVAGLLKRLIEMTAEYACTRKQFNKRLSEFGLIQEKFALMAQKAYVMESMTYLTAGMLDQPGFPDCSIEAAMVKVFSSEAAWQCVSEALQILGGLGYTRDYPYERILRDTRILLIFEGTNEILRMYIALTGLQHAGRILTTRIHELKQAKVSTVMDTVGRRLRDSLGRTVDLGLTGNHGVVHPSLADSANKFEENTYCFGRTVETLLLRFGKTIMEEQLVLKRVANILINLYGMTAVLSRASRSIRIGLRNHDHEVLLANTFCVEAYLQNLFSLSQLDKYAPENLDEQIKKVSQQILEKRAYICAHPLDRTC
翻译修饰 - Q9H845 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T11 | Phosphorylation | Uniprot | |
| K41 | Acetylation | Uniprot | |
| K100 | Ubiquitination | Uniprot | |
| T158 | Phosphorylation | Uniprot | |
| S187 | Phosphorylation | Uniprot | |
| T229 | Phosphorylation | Uniprot | |
| S234 | Phosphorylation | Uniprot | |
| S237 | Phosphorylation | Uniprot | |
| R266 | Methylation | Uniprot | |
| K279 | Ubiquitination | Uniprot | |
| S306 | Phosphorylation | Uniprot | |
| S309 | Phosphorylation | Uniprot | |
| Y325 | Phosphorylation | Uniprot | |
| S337 | Phosphorylation | Uniprot | |
| S474 | Phosphorylation | Uniprot | |
| K599 | Ubiquitination | Uniprot | |
| K608 | Acetylation | Uniprot | |
| K608 | Ubiquitination | Uniprot | |
| Y611 | Phosphorylation | Uniprot | |
| R619 | Methylation | Uniprot |
研究背景
As part of the MCIA complex, primarily participates to the assembly of the mitochondrial complex I and therefore plays a role in oxidative phosphorylation. This moonlighting protein has also a dehydrogenase activity toward a broad range of substrates with greater specificity for long-chain unsaturated acyl-CoAs. However, in vivo, it does not seem to play a primary role in fatty acid oxidation. In addition, the function in complex I assembly is independent of the dehydrogenase activity of the protein.
Mitochondrion inner membrane>Peripheral membrane protein>Matrix side.
Note: Essentially associated with membranes.
Ubiquitously expressed in most normal human tissues and cancer cell lines with high level of expression in heart, skeletal muscles, brain, kidney and liver. In the cerebellum uniquely expressed in the granular layer (at protein level).
Homodimer. Part of the mitochondrial complex I assembly/MCIA complex that comprises at least TMEM126B, NDUFAF1, ECSIT, and ACAD9 (By similarity). Interacts with NDUFAF1 and ECSIT.
Belongs to the acyl-CoA dehydrogenase family.
限制条款
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