产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
展开/折叠
Actinin alpha 3; actinin, alpha; ACTN 3; ACTN3; ACTN3_HUMAN; Alpha actinin skeletal muscle; Alpha actinin skeletal muscle isoform 3; Alpha-Actinin 3; Alpha-actinin skeletal muscle isoform 3; Alpha-actinin-3; F actin cross linking protein; F-actin cross-linking protein; MGC117002; MGC117005; OTTHUMP00000219049; OTTHUMP00000219054;
抗原和靶标
A synthesized peptide derived from human ACTN3, corresponding to a region within C-terminal amino acids.
- Q08043 ACTN3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MMMVMQPEGLGAGEGRFAGGGGGGEYMEQEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPRPDKGKMRFHKIANVNKALDFIASKGVKLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNVQNFHTSWKDGLALCALIHRHRPDLIDYAKLRKDDPIGNLNTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHAFAGAEQAETAANRICKVLAVNQENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQRKLEDFRDYRRLHKPPRIQEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWLLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDRLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSCDQTLQEELARQQVNERLRRQFAAQANAIGPWIQAKVEEVGRLAAGLAGSLEEQMAGLRQQEQNIINYKTNIDRLEGDHQLLQESLVFDNKHTVYSMEHIRVGWEQLLTSIARTINEVENQVLTRDAKGLSQEQLNEFRASFNHFDRKQNGMMEPDDFRACLISMGYDLGEVEFARIMTMVDPNAAGVVTFQAFIDFMTRETAETDTTEQVVASFKILAGDKNYITPEELRRELPAKQAEYCIRRMVPYKGSGAPAGALDYVAFSSALYGESDL
翻译修饰 - Q08043 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| M1 | Acetylation | Uniprot | |
| K45 | Ubiquitination | Uniprot | |
| K49 | Ubiquitination | Uniprot | |
| K61 | Ubiquitination | Uniprot | |
| T64 | Phosphorylation | Uniprot | |
| R90 | Methylation | Uniprot | |
| R93 | Methylation | Uniprot | |
| S116 | Phosphorylation | Uniprot | |
| K117 | Ubiquitination | Uniprot | |
| T137 | Phosphorylation | Uniprot | |
| S154 | Phosphorylation | Uniprot | |
| T158 | Phosphorylation | Uniprot | |
| S159 | Phosphorylation | Uniprot | |
| K209 | Sumoylation | Uniprot | |
| K212 | Sumoylation | Uniprot | |
| Y229 | Phosphorylation | Uniprot | |
| K250 | Acetylation | Uniprot | |
| S257 | Phosphorylation | Uniprot | |
| Y260 | Phosphorylation | Uniprot | |
| R275 | Methylation | Uniprot | |
| K278 | Acetylation | Uniprot | |
| S298 | Phosphorylation | Uniprot | |
| S319 | Phosphorylation | Uniprot | |
| S321 | Phosphorylation | Uniprot | |
| Y333 | Phosphorylation | Uniprot | |
| T354 | Phosphorylation | Uniprot | |
| T357 | Phosphorylation | Uniprot | |
| S376 | Phosphorylation | Uniprot | |
| S418 | Phosphorylation | Uniprot | |
| Y436 | Phosphorylation | Uniprot | |
| S438 | Phosphorylation | Uniprot | |
| S456 | Phosphorylation | Uniprot | |
| K506 | Acetylation | Uniprot | |
| S737 | Phosphorylation | Uniprot | |
| Y851 | Phosphorylation | Uniprot | |
| Y876 | Phosphorylation | Uniprot |
研究背景
F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.
Expressed only in a subset of type 2 skeletal muscle fibers.
Homodimer; antiparallel. Also forms heterodimers with ACTN2. Interacts with MYOZ1.
Belongs to the alpha-actinin family.
研究领域
· Human Diseases > Cardiovascular diseases > Arrhythmogenic right ventricular cardiomyopathy (ARVC).
限制条款
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