AFfirm™ NAB2 Mouse Monoclonal Antibody - #BF8655

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产品: NAB2 小鼠单克隆 抗体
货号: BF8655
描述: Mouse monoclonal antibody to NAB2
应用: ELISA(peptide)
反应: Human
预测: Mouse
分子量: 55~70KD(Observed); 57kD(Calculated).
蛋白ID: Q15742

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NAB2 Peptide

1mg
相关下载
MSDS
说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Mouse IgG
反应:
Human
克隆:
Monoclonal [AFfirm8655]
特异性:
NAB2 Mouse Monoclonal Antibody detects endogenous levels of total NAB2.
偶联:
Unconjugated.
纯化:
Affinity-chromatography.
保存:
Ascitic fluid containing 0.02% proclin300 and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

EGR 1 binding protein 2; EGR-1-binding protein 2; EGR1 binding protein 2; MADER; Melanoma associated delayed early response protein; Melanoma-associated delayed early response protein; MGC75085; Nab 2; nab2; NAB2_HUMAN; NGFI A binding protein 2 (EGR1 binding protein 2); NGFI A binding protein 2; NGFI-A-binding protein 2; Protein MADER;

抗原和靶标

免疫原:

A synthesized peptide derived from human NAB2, corresponding to a region within C-terminal amino acids.

Uniprot:

Q15742(NAB2_HUMAN) >>Visit HPA database.

基因/基因ID:
NAB2(4665)
表达:
Q15742 NAB2_HUMAN:

Widely expressed at low levels. Highly expressed in melanoma cell lines.

序列:
MHRAPSPTAEQPPGGGDSARRTLQPRLKPSARAMALPRTLGELQLYRVLQRANLLSYYETFIQQGGDDVQQLCEAGEEEFLEIMALVGMATKPLHVRRLQKALREWATNPGLFSQPVPAVPVSSIPLFKISETAGTRKGSMSNGHGSPGEKAGSARSFSPKSPLELGEKLSPLPGGPGAGDPRIWPGRSTPESDVGAGGEEEAGSPPFSPPAGGGVPEGTGAGGLAAGGTGGGPDRLEPEMVRMVVESVERIFRSFPRGDAGEVTSLLKLNKKLARSVGHIFEMDDNDSQKEEEIRKYSIIYGRFDSKRREGKQLSLHELTINEAAAQFCMRDNTLLLRRVELFSLSRQVARESTYLSSLKGSRLHPEELGGPPLKKLKQEVGEQSHPEIQQPPPGPESYVPPYRPSLEEDSASLSGESLDGHLQAVGSCPRLTPPPADLPLALPAHGLWSRHILQQTLMDEGLRLARLVSHDRVGRLSPCVPAKPPLAEFEEGLLDRCPAPGPHPALVEGRRSSVKVEAEASRQ

研究背景

功能:

Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability (By similarity).

翻译修饰:

Sumoylation by EGR2 represses EGR2 transcriptional activity in hindbrain.

细胞定位:

Nucleus.
Note: Isoform 2 is not localized to the nucleus.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Widely expressed at low levels. Highly expressed in melanoma cell lines.

蛋白家族:

The NAB conserved domain 1 (NCD1) interacts with EGR1 inhibitory domain and mediates multimerization.

The NAB conserved domain 2 (NCD2) is necessary for transcriptional repression.

Belongs to the NAB family.

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