产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
展开/折叠
Acidic (leucine rich) nuclear phosphoprotein 32 family member E; Acidic leucine-rich nuclear phosphoprotein 32 family member E; AN32E_HUMAN; anp32e; Cerebellar postnatal development protein 1; LANP like protein; LANP-L; LANP-like protein; LANPL; Leucine rich acidic nuclear protein like; MGC5350;
抗原和靶标
A synthesized peptide derived from human ANP32E.
Expressed in peripheral blood leukocytes, colon, small intestine, prostate, thymus, spleen, skeletal muscle, liver and kidney.
- Q9BTT0 AN32E_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEMKKKINLELRNRSPEEVTELVLDNCLCVNGEIEGLNDTFKELEFLSMANVELSSLARLPSLNKLRKLELSDNIISGGLEVLAEKCPNLTYLNLSGNKIKDLSTVEALQNLKNLKSLDLFNCEITNLEDYRESIFELLQQITYLDGFDQEDNEAPDSEEEDDEDGDEDDEEEEENEAGPPEGYEEEEEEEEEEDEDEDEDEDEAGSELGEGEEEVGLSYLMKEEIQDEEDDDDYVEEGEEEEEEEEGGLRGEKRKRDAEDDGEEEDD
研究背景
Histone chaperone that specifically mediates the genome-wide removal of histone H2A.Z/H2AZ1 from the nucleosome: removes H2A.Z/H2AZ1 from its normal sites of deposition, especially from enhancer and insulator regions. Not involved in deposition of H2A.Z/H2AZ1 in the nucleosome. May stabilize the evicted H2A.Z/H2AZ1-H2B dimer, thus shifting the equilibrium towards dissociation and the off-chromatin state. Inhibits activity of protein phosphatase 2A (PP2A). Does not inhibit protein phosphatase 1. May play a role in cerebellar development and synaptogenesis.
Phosphorylated. The phosphorylation is nuclear localization signal (NLS)-dependent (By similarity).
Cytoplasm. Nucleus.
Expressed in peripheral blood leukocytes, colon, small intestine, prostate, thymus, spleen, skeletal muscle, liver and kidney.
The H2A.Z-interacting domain (ZID) mediates a direct interaction with H2A.Z/H2AZ1.
Belongs to the ANP32 family.
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