AFfirm™ GLUD2 Mouse Monoclonal Antibody - #BF8746

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产品: GLUD2 小鼠 单克隆 抗体
货号: BF8746
描述: Mouse monoclonal antibody to GLUD2
应用: WB
反应: Human
预测: Human
分子量: 50-60kD; 61kD(Calculated).
蛋白号: P49448

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 100ul RMB¥ 888 2300 现货

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MS Report
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实验方案
WB Handbook
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产品描述

来源:
Mouse
应用:
WB 1:500-1:3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human
克隆:
Monoclonal [AFfirm8746]
特异性:
GLUD2 Mouse Monoclonal Antibody detects endogenous levels of GLUD2.
偶联:
Unconjugated.
纯化:
Affinity-chromatography.
保存:
Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

DHE4_HUMAN; GDH 2; GDH; GDH2; GLUD2; GLUDP1; Glutamate dehydrogenase 2; Glutamate dehydrogenase 2 mitochondrial; Glutamate dehydrogenase pseudogene 1; mitochondrial;

抗原和靶标

免疫原:

A synthesized peptide derived from human GLUD2.

Uniprot:

P49448(DHE4_HUMAN) >>Visit HPA database.

基因/基因ID:
GLUD2(2747)
表达:
P49448 DHE4_HUMAN:

Expressed in retina, testis and, at a lower level, brain.

序列:
MYRYLAKALLPSRAGPAALGSAANHSAALLGRGRGQPAAASQPGLALAARRHYSELVADREDDPNFFKMVEGFFDRGASIVEDKLVKDLRTQESEEQKRNRVRGILRIIKPCNHVLSLSFPIRRDDGSWEVIEGYRAQHSQHRTPCKGGIRYSTDVSVDEVKALASLMTYKCAVVDVPFGGAKAGVKINPKNYTENELEKITRRFTMELAKKGFIGPGVDVPAPDMNTGEREMSWIADTYASTIGHYDINAHACVTGKPISQGGIHGRISATGRGVFHGIENFINEASYMSILGMTPGFRDKTFVVQGFGNVGLHSMRYLHRFGAKCIAVGESDGSIWNPDGIDPKELEDFKLQHGSILGFPKAKPYEGSILEVDCDILIPAATEKQLTKSNAPRVKAKIIAEGANGPTTPEADKIFLERNILVIPDLYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNYHLLLSVQESLERKFGKHGGTIPIVPTAEFQDSISGASEKDIVHSALAYTMERSARQIMHTAMKYNLGLDLRTAAYVNAIEKVFKVYSEAGVTFT

研究背景

功能:

Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission.

翻译修饰:

Stoichiometry shows that ADP-ribosylation occurs in one subunit per catalytically active homohexamer.

细胞定位:

Mitochondrion matrix.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Expressed in retina, testis and, at a lower level, brain.

亚基结构:

Homohexamer.

蛋白家族:

Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

研究领域

· Cellular Processes > Cell growth and death > Necroptosis.   (View pathway)

· Metabolism > Amino acid metabolism > Arginine biosynthesis.

· Metabolism > Amino acid metabolism > Alanine, aspartate and glutamate metabolism.

· Metabolism > Metabolism of other amino acids > D-Glutamine and D-glutamate metabolism.

· Metabolism > Energy metabolism > Nitrogen metabolism.

· Metabolism > Global and overview maps > Metabolic pathways.

· Metabolism > Global and overview maps > Carbon metabolism.

· Organismal Systems > Excretory system > Proximal tubule bicarbonate reclamation.

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