产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
展开/折叠
AI462440; expressed in T cells and eosinophils in atopic dermatitis; faf2; FAF2_HUMAN; Fas associated factor family member 2; FAS-associated factor 2; KIAA0887; Protein ETEA; Protein expressed in T cells and eosinophils in atopic dermatitis; Protein expressed in T-cells and eosinophils in atopic dermatitis; UBX domain containing 8; UBX domain protein 3B; UBX domain-containing protein 3B; UBX domain-containing protein 8; UBXD8; UBXN3B;
抗原和靶标
- Q96CS3 FAF2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAAPEERDLTQEQTEKLLQFQDLTGIESMDQCRHTLEQHNWNIEAAVQDRLNEQEGVPSVFNPPPSRPLQVNTADHRIYSYVVSRPQPRGLLGWGYYLIMLPFRFTYYTILDIFRFALRFIRPDPRSRVTDPVGDIVSFMHSFEEKYGRAHPVFYQGTYSQALNDAKRELRFLLVYLHGDDHQDSDEFCRNTLCAPEVISLINTRMLFWACSTNKPEGYRVSQALRENTYPFLAMIMLKDRRMTVVGRLEGLIQPDDLINQLTFIMDANQTYLVSERLEREERNQTQVLRQQQDEAYLASLRADQEKERKKREERERKRRKEEEVQQQKLAEERRRQNLQEEKERKLECLPPEPSPDDPESVKIIFKLPNDSRVERRFHFSQSLTVIHDFLFSLKESPEKFQIEANFPRRVLPCIPSEEWPNPPTLQEAGLSHTEVLFVQDLTDE
翻译修饰 - Q96CS3 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| T10 | Phosphorylation | Uniprot | |
| T14 | Phosphorylation | Uniprot | |
| K16 | Ubiquitination | Uniprot | |
| S66 | Phosphorylation | Uniprot | |
| Y79 | Phosphorylation | Uniprot | |
| S80 | Phosphorylation | Uniprot | |
| Y81 | Phosphorylation | Uniprot | |
| S142 | Phosphorylation | Uniprot | |
| K146 | Ubiquitination | Uniprot | |
| T158 | Phosphorylation | Uniprot | |
| K167 | Acetylation | Uniprot | |
| K167 | Ubiquitination | Uniprot | |
| K215 | Ubiquitination | Uniprot | |
| T244 | Phosphorylation | Uniprot | |
| Y297 | Phosphorylation | Uniprot | |
| S300 | Phosphorylation | Uniprot | |
| K307 | Ubiquitination | Uniprot | |
| K321 | Ubiquitination | Uniprot | |
| K329 | Ubiquitination | Uniprot | |
| K343 | Ubiquitination | Uniprot | |
| K346 | Ubiquitination | Uniprot | |
| S355 | Phosphorylation | Uniprot | |
| K363 | Ubiquitination | Uniprot | |
| K367 | Ubiquitination | Uniprot | |
| K395 | Ubiquitination | Uniprot | |
| K400 | Ubiquitination | Uniprot |
研究背景
Plays an important role in endoplasmic reticulum-associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway. Involved in inhibition of lipid droplet degradation by binding to phospholipase PNPL2 and inhibiting its activity by promoting dissociation of PNPL2 from its endogenous activator, ABHD5 which inhibits the rate of triacylglycerol hydrolysis.
Cytoplasm. Lipid droplet. Endoplasmic reticulum.
Broadly expressed, with highest levels in brain.
Identified in a complex that contains SEL1L, OS9, FAF2/UBXD8, UBE2J1/UBC6E and AUP1. Interacts with YOD1. Interacts (via N-terminus) with UBQLN2 (via C-terminus). Interacts with PNPLA2 and UBAC2. Interacts with ZFAND2B; probably through VCP. Interacts with LMBR1L.
限制条款
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