产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
展开/折叠
CP26; CP26B_HUMAN; CYP26A2; cyp26b1; Cytochrome P450 26A2; Cytochrome P450 26B1; Cytochrome P450 family 26 subfamily B polypeptide 1; Cytochrome P450 retinoic acid-inactivating 2; Cytochrome P450 retinoid metabolizing protein; Cytochrome P450 subfamily XXVIA, polypeptide 2; Cytochrome P450 subfamily XXVIB polypeptide 1; Cytochrome P450RAI-2; DKFZp686G0638; dol; EC 1.14.; fc21d03; MGC129613; P450 26A2; P450 retinoic acid inactivating 2; P450RAI 2; P450RAI2; Retinoic acid metabolizing cytochrome; Retinoic acid-metabolizing cytochrome; RHFCA; stocksteif; wu:fc21d03; wu:fc26h10; zgc:76999;
抗原和靶标
- Q9NR63 CP26B_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLFEGLDLVSALATLAACLVSVTLLLAVSQQLWQLRWAATRDKSCKLPIPKGSMGFPLIGETGHWLLQGSGFQSSRREKYGNVFKTHLLGRPLIRVTGAENVRKILMGEHHLVSTEWPRSTRMLLGPNTVSNSIGDIHRNKRKVFSKIFSHEALESYLPKIQLVIQDTLRAWSSHPEAINVYQEAQKLTFRMAIRVLLGFSIPEEDLGHLFEVYQQFVDNVFSLPVDLPFSGYRRGIQARQILQKGLEKAIREKLQCTQGKDYLDALDLLIESSKEHGKEMTMQELKDGTLELIFAAYATTASASTSLIMQLLKHPTVLEKLRDELRAHGILHSGGCPCEGTLRLDTLSGLRYLDCVIKEVMRLFTPISGGYRTVLQTFELDGFQIPKGWSVMYSIRDTHDTAPVFKDVNVFDPDRFSQARSEDKDGRFHYLPFGGGVRTCLGKHLAKLFLKVLAVELASTSRFELATRTFPRITLVPVLHPVDGLSVKFFGLDSNQNEILPETEAMLSATV
翻译修饰 - Q9NR63 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K275 | Ubiquitination | Uniprot | |
| T290 | Phosphorylation | Uniprot | |
| Y298 | Phosphorylation | Uniprot | |
| T317 | Phosphorylation | Uniprot | |
| K321 | Ubiquitination | Uniprot | |
| S462 | Phosphorylation | Uniprot | |
| T470 | Phosphorylation | Uniprot |
研究背景
Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13-cis-RA. Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH-RA. Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4. Essential for postnatal survival. Plays a central role in germ cell development: acts by degrading RA in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required for the maintenance of the undifferentiated state of male germ cells during embryonic development in Sertoli cells, inducing arrest in G0 phase of the cell cycle and preventing meiotic entry. Plays a role in skeletal development, both at the level of patterning and in the ossification of bone and the establishment of some synovial joints.
Has also a significant activity in oxidation of tazarotenic acid and may therefore metabolize that xenobiotic in vivo.
Endoplasmic reticulum membrane>Peripheral membrane protein. Microsome membrane>Peripheral membrane protein.
Highly expressed in brain, particularly in the cerebellum and pons.
Belongs to the cytochrome P450 family.
研究领域
· Metabolism > Metabolism of cofactors and vitamins > Retinol metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
限制条款
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