产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
展开/折叠
5033430J04Rik; AI131596; AI317140; D4Ertd767e; DKFZp547F162; Epcs32; FLB7527; FLJ31599; FLJ35510; MGC19722; MGC20372; MGC2297; MGC93869; NASP; NASP_HUMAN; nuclear autoantigenic sperm protein (histone binding); Nuclear autoantigenic sperm protein; PRO1999; RP23 233B9.9;
抗原和靶标
- P49321 NASP_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAMESTATAAVAAELVSADKIEDVPAPSTSADKVESLDVDSEAKKLLGLGQKHLVMGDIPAAVNAFQEAASLLGKKYGETANECGEAFFFYGKSLLELARMENGVLGNALEGVHVEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFTPGGGGSSVSMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPEVNGGSGDAVPSGNEVSENMEEEAENQAESRAAVEGTVEAGATVESTAC
翻译修饰 - P49321 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| K20 | Acetylation | Uniprot | |
| S28 | Phosphorylation | Uniprot | |
| S30 | Phosphorylation | Uniprot | |
| K33 | Acetylation | Uniprot | |
| K33 | Ubiquitination | Uniprot | |
| S36 | Phosphorylation | Uniprot | |
| S41 | Phosphorylation | Uniprot | |
| K45 | Ubiquitination | Uniprot | |
| K52 | Ubiquitination | Uniprot | |
| S71 | Phosphorylation | Uniprot | |
| K75 | Ubiquitination | Uniprot | |
| K76 | Ubiquitination | Uniprot | |
| K93 | Ubiquitination | Uniprot | |
| S94 | Phosphorylation | Uniprot | |
| T123 | Phosphorylation | Uniprot | |
| S127 | Phosphorylation | Uniprot | |
| R140 | Methylation | Uniprot | |
| Y148 | Phosphorylation | Uniprot | |
| K154 | Acetylation | Uniprot | |
| T170 | Phosphorylation | Uniprot | |
| S176 | Phosphorylation | Uniprot | |
| K180 | Acetylation | Uniprot | |
| S189 | Phosphorylation | Uniprot | |
| S191 | Phosphorylation | Uniprot | |
| T202 | Phosphorylation | Uniprot | |
| S210 | Phosphorylation | Uniprot | |
| T228 | Phosphorylation | Uniprot | |
| K231 | Ubiquitination | Uniprot | |
| S244 | Phosphorylation | Uniprot | |
| S246 | Phosphorylation | Uniprot | |
| T248 | Phosphorylation | Uniprot | |
| C254 | S-Nitrosylation | Uniprot | |
| S269 | Phosphorylation | Uniprot | |
| T291 | Phosphorylation | Uniprot | |
| S299 | Phosphorylation | Uniprot | |
| S321 | Phosphorylation | Uniprot | |
| S344 | Phosphorylation | Uniprot | |
| S384 | Phosphorylation | Uniprot | |
| T390 | Phosphorylation | Uniprot | |
| T396 | Phosphorylation | Uniprot | |
| S397 | Phosphorylation | Uniprot | |
| T402 | Phosphorylation | Uniprot | |
| K405 | Ubiquitination | Uniprot | |
| S408 | Phosphorylation | Uniprot | |
| K413 | Ubiquitination | Uniprot | |
| K417 | Acetylation | Uniprot | |
| K417 | Ubiquitination | Uniprot | |
| S421 | Phosphorylation | Uniprot | |
| T425 | Phosphorylation | Uniprot | |
| K426 | Ubiquitination | Uniprot | |
| S428 | Phosphorylation | Uniprot | |
| S432 | Phosphorylation | Uniprot | |
| K442 | Ubiquitination | Uniprot | |
| T448 | Phosphorylation | Uniprot | |
| K450 | Acetylation | Uniprot | |
| S451 | Phosphorylation | Uniprot | |
| K455 | Acetylation | Uniprot | |
| T464 | Phosphorylation | Uniprot | |
| T477 | Phosphorylation | Uniprot | |
| S480 | Phosphorylation | Uniprot | |
| T490 | Phosphorylation | Uniprot | |
| S497 | Phosphorylation | Uniprot | |
| S503 | Phosphorylation | Uniprot | |
| T534 | Phosphorylation | Uniprot | |
| K535 | Ubiquitination | Uniprot | |
| Y540 | Phosphorylation | Uniprot | |
| S567 | Phosphorylation | Uniprot | |
| Y575 | Phosphorylation | Uniprot | |
| S598 | Phosphorylation | Uniprot | |
| R617 | Methylation | Uniprot | |
| K626 | Ubiquitination | Uniprot | |
| K636 | Sumoylation | Uniprot | |
| K643 | Acetylation | Uniprot | |
| K643 | Ubiquitination | Uniprot | |
| K652 | Ubiquitination | Uniprot | |
| K657 | Ubiquitination | Uniprot | |
| S659 | Phosphorylation | Uniprot | |
| S662 | Phosphorylation | Uniprot | |
| K671 | Ubiquitination | Uniprot | |
| T683 | Phosphorylation | Uniprot | |
| S689 | Phosphorylation | Uniprot | |
| S690 | Phosphorylation | Uniprot | |
| S696 | Phosphorylation | Uniprot | |
| K698 | Acetylation | Uniprot | |
| K698 | Ubiquitination | Uniprot | |
| T700 | Phosphorylation | Uniprot | |
| S704 | Phosphorylation | Uniprot | |
| S705 | Phosphorylation | Uniprot | |
| S706 | Phosphorylation | Uniprot | |
| S713 | Phosphorylation | Uniprot | |
| K721 | Methylation | Uniprot | |
| S726 | Phosphorylation | Uniprot | |
| K733 | Acetylation | Uniprot | |
| K734 | Acetylation | Uniprot | |
| K736 | Acetylation | Uniprot | |
| K736 | Sumoylation | Uniprot | |
| S745 | Phosphorylation | Uniprot | |
| S751 | Phosphorylation | Uniprot | |
| S756 | Phosphorylation | Uniprot | |
| C788 | S-Nitrosylation | Uniprot |
研究背景
Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA.
Cytoplasm. Nucleus.
Isoform 1 is testis- and sperm-specific.
Binds to linker H1 histones but not to core histones (By similarity). Interacts with histones H2A, H2B, H3 and H4. Also binds to HSP90 in the cytoplasm. This interaction stimulates binding of NASP to HIST1H1T/H1T (By similarity).
Belongs to the NASP family.
限制条款
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