产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
展开/折叠
AdoMet; AdoMet synthetase 1; AI046368; Ams; MAT; MAT I/III; MATA1; Methionine adenosyltransferase 1; Methionine adenosyltransferase I, alpha; Methionine adenosyltransferase I/III; MGC108563; S adenosylmethionine synthetase isoform type 1; SADE; SAMS; SAMS1;
抗原和靶标
- Q00266 METK1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MNGPVDGLCDHSLSEGVFMFTSESVGEGHPDKICDQISDAVLDAHLKQDPNAKVACETVCKTGMVLLCGEITSMAMVDYQRVVRDTIKHIGYDDSAKGFDFKTCNVLVALEQQSPDIAQCVHLDRNEEDVGAGDQGLMFGYATDETEECMPLTIILAHKLNARMADLRRSGLLPWLRPDSKTQVTVQYMQDNGAVIPVRIHTIVISVQHNEDITLEEMRRALKEQVIRAVVPAKYLDEDTVYHLQPSGRFVIGGPQGDAGVTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKAGLCRRVLVQVSYAIGVAEPLSISIFTYGTSQKTERELLDVVHKNFDLRPGVIVRDLDLKKPIYQKTACYGHFGRSEFPWEVPRKLVF
翻译修饰 - Q00266 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S73 | Phosphorylation | Uniprot | |
| K223 | Ubiquitination | Uniprot | |
| R264 | Methylation | Uniprot | |
| K285 | Ubiquitination | Uniprot | |
| K289 | Ubiquitination | Uniprot | |
| S293 | Phosphorylation | Uniprot | |
| K303 | Ubiquitination | Uniprot | |
| T341 | Phosphorylation | Uniprot | |
| K351 | Ubiquitination | Uniprot |
研究背景
Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.
S-nitrosylation of Cys-120 inactivates the enzyme.
An intrachain disulfide bond can be formed. The protein structure shows that the relevant Cys residues are in a position that would permit formation of a disulfide bond.
Expressed in liver.
Homotetramer (MAT-I); dimer of dimers. Homodimer (MAT-III) (By similarity).
Belongs to the AdoMet synthase family.
研究领域
· Metabolism > Amino acid metabolism > Cysteine and methionine metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
· Metabolism > Global and overview maps > Biosynthesis of amino acids.
限制条款
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