产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
展开/折叠
C80703; cytoplasmic 3; D8Ertd281e; NF AT4; NF ATc3; NF-AT4; NF-ATc3; NFAC3_HUMAN; NFATc3; NFATx; Nuclear factor of activated T cells, cytoplasmic 3; nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3; Nuclear factor of activated T-cells; T cell transcription factor NFAT4; T-cell transcription factor NFAT4;
抗原和靶标
Isoform 1 is predominantly expressed in thymus and is also found in peripheral blood leukocytes and kidney. Isoform 2 is predominantly expressed in skeletal muscle and is also found in thymus, kidney, testis, spleen, prostate, ovary, small intestine, heart, placenta and pancreas. Isoform 3 is expressed in thymus and kidney. Isoform 4 is expressed in thymus and skeletal muscle.
- Q12968 NFAC3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MTTANCGAHDELDFKLVFGEDGAPAPPPPGSRPADLEPDDCASIYIFNVDPPPSTLTTPLCLPHHGLPSHSSVLSPSFQLQSHKNYEGTCEIPESKYSPLGGPKPFECPSIQITSISPNCHQELDAHEDDLQINDPEREFLERPSRDHLYLPLEPSYRESSLSPSPASSISSRSWFSDASSCESLSHIYDDVDSELNEAAARFTLGSPLTSPGGSPGGCPGEETWHQQYGLGHSLSPRQSPCHSPRSSVTDENWLSPRPASGPSSRPTSPCGKRRHSSAEVCYAGSLSPHHSPVPSPGHSPRGSVTEDTWLNASVHGGSGLGPAVFPFQYCVETDIPLKTRKTSEDQAAILPGKLELCSDDQGSLSPARETSIDDGLGSQYPLKKDSCGDQFLSVPSPFTWSKPKPGHTPIFRTSSLPPLDWPLPAHFGQCELKIEVQPKTHHRAHYETEGSRGAVKASTGGHPVVKLLGYNEKPINLQMFIGTADDRYLRPHAFYQVHRITGKTVATASQEIIIASTKVLEIPLLPENNMSASIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHIPQPSGKVLSLQIASIPVECSQRSAQELPHIEKYSINSCSVNGGHEMVVTGSNFLPESKIIFLEKGQDGRPQWEVEGKIIREKCQGAHIVLEVPPYHNPAVTAAVQVHFYLCNGKRKKSQSQRFTYTPVLMKQEHREEIDLSSVPSLPVPHPAQTQRPSSDSGCSHDSVLSGQRSLICSIPQTYASMVTSSHLPQLQCRDESVSKEQHMIPSPIVHQPFQVTPTPPVGSSYQPMQTNVVYNGPTCLPINAASSQEFDSVLFQQDATLSGLVNLGCQPLSSIPFHSSNSGSTGHLLAHTPHSVHTLPHLQSMGYHCSNTGQRSLSSPVADQITGQPSSQLQPITYGPSHSGSATTASPAASHPLASSPLSGPPSPQLQPMPYQSPSSGTASSPSPATRMHSGQHSTQAQSTGQGGLSAPSSLICHSLCDPASFPPDGATVSIKPEPEDREPNFATIGLQDITLDDVNEIIGRDMSQISVSQGAGVSRQAPLPSPESLDLGRSDGL
翻译修饰 - Q12968 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S82 | Phosphorylation | Uniprot | |
| Y86 | Phosphorylation | Uniprot | |
| T89 | Phosphorylation | Uniprot | |
| K96 | Ubiquitination | Uniprot | |
| S98 | Phosphorylation | Uniprot | |
| S117 | Phosphorylation | Uniprot | |
| S145 | Phosphorylation | Uniprot | |
| Y150 | Phosphorylation | Uniprot | |
| S163 | Phosphorylation | P45984 (MAPK9) | Uniprot |
| S165 | Phosphorylation | P45984 (MAPK9) | Uniprot |
| S168 | Phosphorylation | Uniprot | |
| S169 | Phosphorylation | Uniprot | |
| S171 | Phosphorylation | Uniprot | |
| S172 | Phosphorylation | Uniprot | |
| S174 | Phosphorylation | Uniprot | |
| S177 | Phosphorylation | Uniprot | |
| S180 | Phosphorylation | Uniprot | |
| S181 | Phosphorylation | Uniprot | |
| S184 | Phosphorylation | Uniprot | |
| S186 | Phosphorylation | Uniprot | |
| T204 | Phosphorylation | P48729 (CSNK1A1) | Uniprot |
| S207 | Phosphorylation | P48729 (CSNK1A1) | Uniprot |
| T210 | Phosphorylation | P48729 (CSNK1A1) | Uniprot |
| S211 | Phosphorylation | P48729 (CSNK1A1) | Uniprot |
| S215 | Phosphorylation | P48729 (CSNK1A1) | Uniprot |
| S236 | Phosphorylation | Uniprot | |
| S240 | Phosphorylation | Uniprot | |
| S244 | Phosphorylation | Uniprot | |
| S247 | Phosphorylation | Uniprot | |
| S248 | Phosphorylation | Uniprot | |
| S261 | Phosphorylation | Uniprot | |
| S265 | Phosphorylation | Uniprot | |
| T268 | Phosphorylation | Uniprot | |
| S269 | Phosphorylation | Uniprot | |
| S277 | Phosphorylation | Uniprot | |
| S288 | Phosphorylation | Uniprot | |
| S292 | Phosphorylation | Uniprot | |
| S296 | Phosphorylation | Uniprot | |
| S300 | Phosphorylation | Uniprot | |
| K342 | Ubiquitination | Uniprot | |
| S344 | Phosphorylation | Uniprot | |
| K354 | Ubiquitination | Uniprot | |
| S364 | Phosphorylation | Uniprot | |
| S366 | Phosphorylation | Uniprot | |
| T371 | Phosphorylation | Uniprot | |
| S372 | Phosphorylation | Uniprot | |
| K384 | Ubiquitination | Uniprot | |
| K403 | Ubiquitination | Uniprot | |
| K405 | Ubiquitination | Uniprot | |
| S415 | Phosphorylation | Uniprot | |
| S416 | Phosphorylation | Uniprot | |
| K457 | Ubiquitination | Uniprot | |
| K467 | Ubiquitination | Uniprot | |
| K542 | Ubiquitination | Uniprot | |
| S546 | Phosphorylation | Uniprot | |
| K552 | Ubiquitination | Uniprot | |
| K630 | Ubiquitination | Uniprot | |
| K636 | Ubiquitination | Uniprot | |
| K649 | Ubiquitination | Uniprot | |
| S730 | Phosphorylation | Uniprot | |
| S731 | Phosphorylation | Uniprot | |
| S742 | Phosphorylation | Uniprot | |
| Y884 | Phosphorylation | Uniprot | |
| S1045 | Phosphorylation | Uniprot | |
| S1048 | Phosphorylation | Uniprot | |
| S1063 | Phosphorylation | Uniprot | |
| S1066 | Phosphorylation | Uniprot |
研究背景
Acts as a regulator of transcriptional activation. Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2. Along with NFATC4, involved in embryonic heart development (By similarity).
Phosphorylated by NFATC-kinase; dephosphorylated by calcineurin.
Cytoplasm. Nucleus.
Note: Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription.
Isoform 1 is predominantly expressed in thymus and is also found in peripheral blood leukocytes and kidney. Isoform 2 is predominantly expressed in skeletal muscle and is also found in thymus, kidney, testis, spleen, prostate, ovary, small intestine, heart, placenta and pancreas. Isoform 3 is expressed in thymus and kidney. Isoform 4 is expressed in thymus and skeletal muscle.
Member of the multicomponent NFATC transcription complex that consists of at least two components, a pre-existing cytoplasmic component NFATC2 and an inducible nuclear component NFATC1. Other members such as NFATC4, or members of the activating protein-1 family, MAF, GATA4 and Cbp/p300 can also bind the complex. NFATC proteins bind to DNA as monomers.
Rel Similarity Domain (RSD) allows DNA-binding and cooperative interactions with AP1 factors.
研究领域
· Cellular Processes > Cell growth and death > Cellular senescence. (View pathway)
· Environmental Information Processing > Signal transduction > MAPK signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > cGMP-PKG signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > Wnt signaling pathway. (View pathway)
· Human Diseases > Infectious diseases: Viral > Hepatitis B.
· Human Diseases > Infectious diseases: Viral > HTLV-I infection.
· Organismal Systems > Development > Axon guidance. (View pathway)
· Organismal Systems > Immune system > Th1 and Th2 cell differentiation. (View pathway)
· Organismal Systems > Immune system > Th17 cell differentiation. (View pathway)
· Organismal Systems > Immune system > T cell receptor signaling pathway. (View pathway)
· Organismal Systems > Immune system > B cell receptor signaling pathway. (View pathway)
· Organismal Systems > Endocrine system > Oxytocin signaling pathway.
限制条款
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