产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
展开/折叠
FGFR signaling adaptor SNT; FGFR signalling adaptor; FGFR substrate 2; FGFR-signaling adaptor SNT; Fibroblast growth factor receptor substrate 2; FRS 2; FRS2; FRS2_HUMAN; FRS2A; FRS2alpha; SNT 1; SNT; SNT-1; SNT1; Suc 1 Associated Neurotrophic Factor Target; Suc1 associated neurotrophic factor target 1; Suc1-associated neurotrophic factor target 1;
抗原和靶标
Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.
- Q8WU20 FRS2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGSCCSCPDKDTVPDNHRNKFKVINVDDDGNELGSGIMELTDTELILYTRKRDSVKWHYLCLRRYGYDSNLFSFESGRRCQTGQGIFAFKCARAEELFNMLQEIMQNNSINVVEEPVVERNNHQTELEVPRTPRTPTTPGFAAQNLPNGYPRYPSFGDASSHPSSRHPSVGSARLPSVGEESTHPLLVAEEQVHTYVNTTGVQEERKNRTSVHVPLEARVSNAESSTPKEEPSSIEDRDPQILLEPEGVKFVLGPTPVQKQLMEKEKLEQLGRDQVSGSGANNTEWDTGYDSDERRDAPSVNKLVYENINGLSIPSASGVRRGRLTSTSTSDTQNINNSAQRRTALLNYENLPSLPPVWEARKLSRDEDDNLGPKTPSLNGYHNNLDPMHNYVNTENVTVPASAHKIEYSRRRDCTPTVFNFDIRRPSLEHRQLNYIQVDLEGGSDSDNPQTPKTPTTPLPQTPTRRTELYAVIDIERTAAMSNLQKALPRDDGTSRKTRHNSTDLPM
翻译修饰 - Q8WU20 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| G2 | Myristoylation | Uniprot | |
| T49 | Phosphorylation | Uniprot | |
| Y59 | Phosphorylation | Uniprot | |
| S73 | Phosphorylation | Uniprot | |
| S76 | Phosphorylation | Uniprot | |
| S109 | Phosphorylation | Uniprot | |
| T125 | Phosphorylation | Uniprot | |
| T132 | Phosphorylation | Uniprot | |
| T135 | Phosphorylation | Uniprot | |
| T137 | Phosphorylation | Uniprot | |
| T138 | Phosphorylation | Uniprot | |
| Y150 | Phosphorylation | Uniprot | |
| Y153 | Phosphorylation | Uniprot | |
| S155 | Phosphorylation | Uniprot | |
| S169 | Phosphorylation | Uniprot | |
| S177 | Phosphorylation | Uniprot | |
| T183 | Phosphorylation | Uniprot | |
| Y196 | Phosphorylation | Uniprot | |
| T200 | Phosphorylation | Uniprot | |
| S211 | Phosphorylation | Uniprot | |
| S221 | Phosphorylation | Uniprot | |
| S226 | Phosphorylation | Uniprot | |
| T227 | Phosphorylation | Uniprot | |
| K267 | Ubiquitination | Uniprot | |
| Y290 | Phosphorylation | Uniprot | |
| S292 | Phosphorylation | Uniprot | |
| S300 | Phosphorylation | Uniprot | |
| Y306 | Phosphorylation | Uniprot | |
| S313 | Phosphorylation | Uniprot | |
| S316 | Phosphorylation | Uniprot | |
| T326 | Phosphorylation | Uniprot | |
| S327 | Phosphorylation | Uniprot | |
| T328 | Phosphorylation | Uniprot | |
| S329 | Phosphorylation | Uniprot | |
| T344 | Phosphorylation | Uniprot | |
| Y349 | Phosphorylation | Uniprot | |
| S354 | Phosphorylation | Uniprot | |
| S365 | Phosphorylation | Uniprot | |
| T376 | Phosphorylation | Uniprot | |
| S378 | Phosphorylation | Uniprot | |
| Y392 | Phosphorylation | Uniprot | |
| T395 | Phosphorylation | Uniprot | |
| S403 | Phosphorylation | Uniprot | |
| S428 | Phosphorylation | Uniprot | |
| Y436 | Phosphorylation | Uniprot | |
| S445 | Phosphorylation | Uniprot | |
| S447 | Phosphorylation | Uniprot | |
| T452 | Phosphorylation | Uniprot | |
| T455 | Phosphorylation | Uniprot | |
| T457 | Phosphorylation | Uniprot | |
| T458 | Phosphorylation | Uniprot | |
| T463 | Phosphorylation | Uniprot | |
| T465 | Phosphorylation | Uniprot | |
| T468 | Phosphorylation | Uniprot | |
| Y471 | Phosphorylation | Uniprot | |
| T479 | Phosphorylation | Uniprot | |
| S483 | Phosphorylation | Uniprot | |
| T499 | Phosphorylation | Uniprot | |
| S503 | Phosphorylation | Uniprot | |
| T504 | Phosphorylation | Uniprot |
研究背景
Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.
Phosphorylated by ULK2 in vitro (By similarity). Phosphorylated on tyrosine residues upon stimulation by NGF or FGF2. Phosphorylated on tyrosine residues by activated ALK and FGFR1. Phosphorylated on tyrosine residues upon activation of FGFR2 and FGFR3. Phosphorylated on threonine residues by MAP kinases; this inhibits tyrosine phosphorylation, and thereby down-regulates FRS2-mediated activation of MAP kinases.
Ubiquitinated when tyrosine phosphorylated and in a complex with GRB2. The unphosphorylated form is not subject to ubiquitination (By similarity).
Endomembrane system.
Note: Cytoplasmic, membrane-bound.
Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.
Part of a complex containing FRS2, GRB2, GAB1, PIK3R1 and SOS1. Part of a complex containing GRB2 and CBL. Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Binds RET (By similarity). Binds ALK, FGFR1, CKS2, MAPK1/ERK2, MAPK3/ERK1 and SRC. The tyrosine-phosphorylated protein binds the SH2 domains of GRB2 and PTPN11. Interacts with NTRK1, NTRK2 and NTRK3 (phosphorylated upon ligand-binding).
研究领域
· Human Diseases > Cancers: Overview > Proteoglycans in cancer.
· Organismal Systems > Nervous system > Neurotrophin signaling pathway. (View pathway)
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