产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
展开/折叠
ALS; ALS1; Amyotrophic lateral sclerosis 1 adult; Cu/Zn SOD; Cu/Zn superoxide dismutase; Epididymis secretory protein Li 44; HEL S 44; Homodimer; hSod1; Indophenoloxidase A; IPOA; Mn superoxide dismutase; SOD; SOD soluble; SOD1; SOD2; SODC; SODC_HUMAN; Superoxide dismutase [Cu-Zn]; Superoxide dismutase 1; Superoxide dismutase 1 soluble; Superoxide dismutase Cu Zn; Superoxide dismutase cystolic;
抗原和靶标
- P00441 SODC_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTSAGPHFNPLSRKHGGPKDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIGRTLVVHEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ
翻译修饰 - P00441 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| T3 | Phosphorylation | Uniprot | |
| K4 | Ubiquitination | Uniprot | |
| C7 | S-Nitrosylation | Uniprot | |
| K10 | Acetylation | Uniprot | |
| K10 | Ubiquitination | Uniprot | |
| K24 | Acetylation | Uniprot | |
| K24 | Ubiquitination | Uniprot | |
| S26 | Phosphorylation | Uniprot | |
| K31 | Ubiquitination | Uniprot | |
| S35 | Phosphorylation | Uniprot | |
| K37 | Ubiquitination | Uniprot | |
| T40 | Phosphorylation | Uniprot | |
| T59 | Phosphorylation | Uniprot | |
| S60 | Phosphorylation | Uniprot | |
| S69 | Phosphorylation | Uniprot | |
| K71 | Acetylation | Uniprot | |
| K71 | Ubiquitination | Uniprot | |
| K76 | Sumoylation | Uniprot | |
| K76 | Ubiquitination | Uniprot | |
| R80 | Methylation | Uniprot | |
| T89 | Phosphorylation | Uniprot | |
| K92 | Ubiquitination | Uniprot | |
| S99 | Phosphorylation | Uniprot | |
| S103 | Phosphorylation | Uniprot | |
| S106 | Phosphorylation | Uniprot | |
| S108 | Phosphorylation | Uniprot | |
| K123 | Acetylation | Uniprot | |
| K123 | Ubiquitination | Uniprot | |
| K129 | Ubiquitination | Uniprot | |
| K137 | Ubiquitination | Uniprot | |
| R144 | Methylation | Uniprot | |
| C147 | S-Nitrosylation | Uniprot |
研究背景
Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
Unlike wild-type protein, the pathogenic variants ALS1 Arg-38, Arg-47, Arg-86 and Ala-94 are polyubiquitinated by RNF19A leading to their proteasomal degradation. The pathogenic variants ALS1 Arg-86 and Ala-94 are ubiquitinated by MARCH5 leading to their proteasomal degradation.
The ditryptophan cross-link at Trp-33 is responsible for the non-disulfide-linked homodimerization. Such modification might only occur in extreme conditions and additional experimental evidence is required.
Palmitoylation helps nuclear targeting and decreases catalytic activity.
Succinylation, adjacent to copper catalytic site, probably inhibits activity. Desuccinylation by SIRT5 enhances activity.
Cytoplasm. Mitochondrion. Nucleus.
Note: Predominantly cytoplasmic; the pathogenic variants ALS1 Arg-86 and Ala-94 gradually aggregates and accumulates in mitochondria.
Homodimer; non-disulfide linked. Homodimerization may take place via the ditryptophan cross-link at Trp-33. The pathogenic variants ALS1 Arg-38, Arg-47, Arg-86 and Ala-94 interact with RNF19A, whereas wild-type protein does not. The pathogenic variants ALS1 Arg-86 and Ala-94 interact with MARCH5, whereas wild-type protein does not.
Belongs to the Cu-Zn superoxide dismutase family.
研究领域
· Cellular Processes > Transport and catabolism > Peroxisome. (View pathway)
· Human Diseases > Neurodegenerative diseases > Amyotrophic lateral sclerosis (ALS).
· Human Diseases > Neurodegenerative diseases > Huntington's disease.
· Human Diseases > Neurodegenerative diseases > Prion diseases.
· Organismal Systems > Aging > Longevity regulating pathway - multiple species. (View pathway)
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