产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
展开/折叠
DNA repair protein XRCC1; RCC; X ray repair complementing defective repair in chinese hamster; X ray Repair Complementing Defective Repair in Chinese Hamster Cells; X ray repair complementing defective repair in chinese hamster cells 1; X ray repair cross complementing 1; X ray repair cross complementing protein 1; X ray repair, complementing defective, repair in Chinese hamster; X-ray repair cross-complementing protein 1; XRCC 1; Xrcc1; XRCC1_HUMAN;
抗原和靶标
Expressed in fibroblasts, retinal pigmented epithelial cells and lymphoblastoid cells (at protein level).
- P18887 XRCC1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPEIRLRHVVSCSSQDSTHCAENLLKADTYRKWRAAKAGEKTISVVLQLEKEEQIHSVDIGNDGSAFVEVLVGSSAGGAGEQDYEVLLVTSSFMSPSESRSGSNPNRVRMFGPDKLVRAAAEKRWDRVKIVCSQPYSKDSPFGLSFVRFHSPPDKDEAEAPSQKVTVTKLGQFRVKEEDESANSLRPGALFFSRINKTSPVTASDPAGPSYAAATLQASSAASSASPVSRAIGSTSKPQESPKGKRKLDLNQEEKKTPSKPPAQLSPSVPKRPKLPAPTRTPATAPVPARAQGAVTGKPRGEGTEPRRPRAGPEELGKILQGVVVVLSGFQNPFRSELRDKALELGAKYRPDWTRDSTHLICAFANTPKYSQVLGLGGRIVRKEWVLDCHRMRRRLPSRRYLMAGPGSSSEEDEASHSGGSGDEAPKLPQKQPQTKTKPTQAAGPSSPQKPPTPEETKAASPVLQEDIDIEGVQSEGQDNGAEDSGDTEDELRRVAEQKEHRLPPGQEENGEDPYAGSTDENTDSEEHQEPPDLPVPELPDFFQGKHFFLYGEFPGDERRKLIRYVTAFNGELEDNMSDRVQFVITAQEWDPSFEEALMDNPSLAFVRPRWIYSCNEKQKLLPHQLYGVVPQA
翻译修饰 - P18887 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K129 | Ubiquitination | Uniprot | |
| K138 | Ubiquitination | Uniprot | |
| S140 | Phosphorylation | Uniprot | |
| S151 | Phosphorylation | Uniprot | |
| S162 | Phosphorylation | Uniprot | |
| K169 | Acetylation | Uniprot | |
| K169 | Ubiquitination | Uniprot | |
| K176 | Sumoylation | Uniprot | |
| S184 | Phosphorylation | O96017 (CHEK2) | Uniprot |
| T198 | Phosphorylation | Uniprot | |
| S199 | Phosphorylation | Uniprot | |
| T202 | Phosphorylation | Uniprot | |
| S204 | Phosphorylation | Uniprot | |
| S210 | Phosphorylation | O96017 (CHEK2) | Uniprot |
| Y211 | Phosphorylation | Uniprot | |
| S224 | Phosphorylation | Uniprot | |
| S226 | Phosphorylation | P24941 (CDK2) | Uniprot |
| S229 | Phosphorylation | P24941 (CDK2) | Uniprot |
| S234 | Phosphorylation | Uniprot | |
| T235 | Phosphorylation | Uniprot | |
| S236 | Phosphorylation | Uniprot | |
| S241 | Phosphorylation | Uniprot | |
| K247 | Sumoylation | Uniprot | |
| K256 | Acetylation | Uniprot | |
| K256 | Sumoylation | Uniprot | |
| T257 | Phosphorylation | Uniprot | |
| S259 | Phosphorylation | Uniprot | |
| K260 | Acetylation | Uniprot | |
| S266 | Phosphorylation | Uniprot | |
| S268 | Phosphorylation | Uniprot | |
| K271 | Acetylation | Uniprot | |
| T279 | Phosphorylation | Uniprot | |
| T281 | Phosphorylation | Uniprot | |
| T284 | Phosphorylation | O96017 (CHEK2) | Uniprot |
| T296 | O-Glycosylation | Uniprot | |
| T296 | Phosphorylation | Uniprot | |
| K298 | Acetylation | Uniprot | |
| R310 | Methylation | Uniprot | |
| K341 | Ubiquitination | Uniprot | |
| K348 | Ubiquitination | Uniprot | |
| S357 | Phosphorylation | Uniprot | |
| T358 | Phosphorylation | Uniprot | |
| T367 | Phosphorylation | Uniprot | |
| Y370 | Phosphorylation | Uniprot | |
| S371 | Phosphorylation | P78527 (PRKDC) | Uniprot |
| K383 | Ubiquitination | Uniprot | |
| S408 | Phosphorylation | P68400 (CSNK2A1) | Uniprot |
| S409 | Phosphorylation | P68400 (CSNK2A1) | Uniprot |
| S410 | Phosphorylation | P68400 (CSNK2A1) | Uniprot |
| S416 | Phosphorylation | P68400 (CSNK2A1) | Uniprot |
| S418 | Phosphorylation | P68400 (CSNK2A1) | Uniprot |
| S421 | Phosphorylation | P68400 (CSNK2A1) | Uniprot |
| K431 | Ubiquitination | Uniprot | |
| T437 | Phosphorylation | Uniprot | |
| T440 | O-Glycosylation | Uniprot | |
| T440 | Phosphorylation | Uniprot | |
| S446 | O-Glycosylation | Uniprot | |
| S446 | Phosphorylation | Uniprot | |
| S447 | O-Glycosylation | Uniprot | |
| S447 | Phosphorylation | Uniprot | |
| T453 | O-Glycosylation | Uniprot | |
| T453 | Phosphorylation | Uniprot | |
| T457 | Phosphorylation | Uniprot | |
| S461 | Phosphorylation | P68400 (CSNK2A1) | Uniprot |
| S475 | Phosphorylation | P68400 (CSNK2A1) | Uniprot |
| S485 | Phosphorylation | P68400 (CSNK2A1) , P19784 (CSNK2A2) | Uniprot |
| T488 | Phosphorylation | P19784 (CSNK2A2) , P68400 (CSNK2A1) | Uniprot |
| Y515 | Phosphorylation | P68400 (CSNK2A1) | Uniprot |
| S518 | Phosphorylation | P68400 (CSNK2A1) , P19784 (CSNK2A2) | Uniprot |
| T519 | Phosphorylation | P68400 (CSNK2A1) , P19784 (CSNK2A2) | Uniprot |
| T523 | Phosphorylation | P19784 (CSNK2A2) , P68400 (CSNK2A1) | Uniprot |
| S525 | Phosphorylation | P68400 (CSNK2A1) | Uniprot |
| S578 | Phosphorylation | P68400 (CSNK2A1) | Uniprot |
| K620 | Ubiquitination | Uniprot | |
| Y627 | Phosphorylation | Uniprot |
研究背景
Involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes. Probably during DNA repair, negatively regulates ADP-ribose levels by modulating ADP-ribosyltransferase PARP1 activity.
Phosphorylation of Ser-371 causes dimer dissociation. Phosphorylation by CK2 promotes interaction with APTX and APLF.
Sumoylated.
Nucleus.
Note: Moves from the nucleoli to the global nuclear chromatin upon DNA damage.
Expressed in fibroblasts, retinal pigmented epithelial cells and lymphoblastoid cells (at protein level).
Homodimer. Interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB) and DNA ligase III (LIG3). Interacts with APTX and APLF. Interacts with APEX1; the interaction is induced by SIRT1 and increases with the acetylated form of APEX1.
研究领域
· Genetic Information Processing > Replication and repair > Base excision repair.
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