产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
展开/折叠
ABC20; ABCB1; ATP binding cassette, sub family B (MDR/TAP), member 1; ATP-binding cassette sub-family B member 1; CD243; CLCS; Colchicin sensitivity; Doxorubicin resistance; GP170; MDR1; MDR1_HUMAN; Multidrug resistance 1; Multidrug resistance protein 1; P glycoprotein 1; P gp; P-glycoprotein 1; PGY1;
抗原和靶标
- P08183 MDR1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDLEGDRNGGAKKKNFFKLNNKSEKDKKEKKPTVSVFSMFRYSNWLDKLYMVVGTLAAIIHGAGLPLMMLVFGEMTDIFANAGNLEDLMSNITNRSDINDTGFFMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVELENAADESKSEIDALEMSSNDSRSSLIRKRSTRRSVRGSQAQDRKLSTKEALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAIINGGLQPAFAIIFSKIIGVFTRIDDPETKRQNSNLFSLLFLALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDSYSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGTKRQ
翻译修饰 - P08183 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S23 | Phosphorylation | Uniprot | |
| T263 | Phosphorylation | Uniprot | |
| K271 | Ubiquitination | Uniprot | |
| K279 | Ubiquitination | Uniprot | |
| K367 | Ubiquitination | Uniprot | |
| K372 | Ubiquitination | Uniprot | |
| K380 | Ubiquitination | Uniprot | |
| K384 | Acetylation | Uniprot | |
| K389 | Ubiquitination | Uniprot | |
| K405 | Sumoylation | Uniprot | |
| K408 | Sumoylation | Uniprot | |
| K411 | Ubiquitination | Uniprot | |
| T422 | Phosphorylation | Uniprot | |
| T496 | Phosphorylation | Uniprot | |
| K515 | Ubiquitination | Uniprot | |
| K519 | Ubiquitination | Uniprot | |
| T522 | Phosphorylation | Uniprot | |
| K536 | Ubiquitination | Uniprot | |
| K617 | Ubiquitination | Uniprot | |
| K619 | Ubiquitination | Uniprot | |
| S644 | Phosphorylation | Uniprot | |
| S658 | Phosphorylation | Uniprot | |
| S660 | Phosphorylation | Uniprot | |
| S661 | Phosphorylation | P17252 (PRKCA) | Uniprot |
| S667 | Phosphorylation | P17612 (PRKACA) , P17252 (PRKCA) | Uniprot |
| S671 | Phosphorylation | P17252 (PRKCA) , P17612 (PRKACA) | Uniprot |
| S675 | Phosphorylation | Uniprot | |
| S683 | Phosphorylation | P17612 (PRKACA) | Uniprot |
| T684 | Phosphorylation | Uniprot | |
| S696 | Phosphorylation | Uniprot | |
| K826 | Ubiquitination | Uniprot | |
| K915 | Ubiquitination | Uniprot | |
| T1015 | Phosphorylation | Uniprot | |
| T1023 | Phosphorylation | Uniprot | |
| T1030 | Phosphorylation | Uniprot | |
| K1062 | Ubiquitination | Uniprot | |
| Y1087 | Phosphorylation | Uniprot | |
| K1093 | Ubiquitination | Uniprot | |
| K1099 | Ubiquitination | Uniprot | |
| K1102 | Methylation | Uniprot | |
| K1172 | Ubiquitination | Uniprot | |
| K1181 | Ubiquitination | Uniprot | |
| K1212 | Ubiquitination | Uniprot | |
| Y1267 | Phosphorylation | Uniprot | |
| S1269 | Phosphorylation | Uniprot |
研究背景
Translocates drugs and phospholipids across the membrane. Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins. Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Cell membrane>Multi-pass membrane protein. Apical cell membrane.
Expressed in liver, kidney, small intestine and brain.
Interacts with PSMB5. Finds in a complex with ABCB1, TFPI2 and PPP2R3C; leading to the dephosphorylation of ABCB1.
Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
研究领域
· Environmental Information Processing > Membrane transport > ABC transporters.
· Human Diseases > Cancers: Overview > MicroRNAs in cancer.
· Human Diseases > Cancers: Specific types > Gastric cancer. (View pathway)
限制条款
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