产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
展开/折叠
40 kDa keratin intermediate filament; CK 19; CK-19; CK19; Cytokeratin 19; Cytokeratin-19; K19; K1C19_HUMAN; K1CS; Keratin 19; Keratin type I 40 kD; Keratin type I 40kD; Keratin type I cytoskeletal 19; Keratin, type I cytoskeletal 19; Keratin, type I, 40 kd; Keratin-19; KRT19; MGC15366;
抗原和靶标
A synthesized peptide derived from human Keratin 19
Expressed in a defined zone of basal keratinocytes in the deep outer root sheath of hair follicles. Also observed in sweat gland and mammary gland ductal and secretory cells, bile ducts, gastrointestinal tract, bladder urothelium, oral epithelia, esophagus, ectocervical epithelium (at protein level). Expressed in epidermal basal cells, in nipple epidermis and a defined region of the hair follicle. Also seen in a subset of vascular wall cells in both the veins and artery of human umbilical cord, and in umbilical cord vascular smooth muscle. Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma in structures that contain dystrophin and spectrin.
- P08727 K1C19_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MTSYSYRQSSATSSFGGLGGGSVRFGPGVAFRAPSIHGGSGGRGVSVSSARFVSSSSSGAYGGGYGGVLTASDGLLAGNEKLTMQNLNDRLASYLDKVRALEAANGELEVKIRDWYQKQGPGPSRDYSHYYTTIQDLRDKILGATIENSRIVLQIDNARLAADDFRTKFETEQALRMSVEADINGLRRVLDELTLARTDLEMQIEGLKEELAYLKKNHEEEISTLRGQVGGQVSVEVDSAPGTDLAKILSDMRSQYEVMAEQNRKDAEAWFTSRTEELNREVAGHTEQLQMSRSEVTDLRRTLQGLEIELQSQLSMKAALEDTLAETEARFGAQLAHIQALISGIEAQLGDVRADSERQNQEYQRLMDIKSRLEQEIATYRSLLEGQEDHYNNLSASKVL
翻译修饰 - P08727 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S3 | Phosphorylation | Uniprot | |
| Y4 | Phosphorylation | Uniprot | |
| R7 | Methylation | Uniprot | |
| S9 | Phosphorylation | Uniprot | |
| S10 | Phosphorylation | Uniprot | |
| T12 | Phosphorylation | Uniprot | |
| S13 | Phosphorylation | Uniprot | |
| S14 | Phosphorylation | Uniprot | |
| S22 | Phosphorylation | Uniprot | |
| R24 | Methylation | Uniprot | |
| R32 | Methylation | Uniprot | |
| S35 | Phosphorylation | P31749 (AKT1) | Uniprot |
| S40 | Phosphorylation | Uniprot | |
| R43 | Methylation | Uniprot | |
| S46 | Phosphorylation | Uniprot | |
| S48 | Phosphorylation | Uniprot | |
| S49 | Phosphorylation | Uniprot | |
| R51 | Methylation | Uniprot | |
| S55 | Phosphorylation | Uniprot | |
| S58 | Phosphorylation | Uniprot | |
| Y61 | Phosphorylation | Uniprot | |
| Y65 | Phosphorylation | Uniprot | |
| T70 | Phosphorylation | Uniprot | |
| S72 | Phosphorylation | Uniprot | |
| K81 | Ubiquitination | Uniprot | |
| S93 | Phosphorylation | Uniprot | |
| Y94 | Phosphorylation | Uniprot | |
| K97 | Acetylation | Uniprot | |
| K97 | Ubiquitination | Uniprot | |
| K111 | Ubiquitination | Uniprot | |
| Y116 | Phosphorylation | Uniprot | |
| K118 | Methylation | Uniprot | |
| K118 | Ubiquitination | Uniprot | |
| Y127 | Phosphorylation | Uniprot | |
| S128 | Phosphorylation | Uniprot | |
| Y130 | Phosphorylation | Uniprot | |
| Y131 | Phosphorylation | Uniprot | |
| T132 | Phosphorylation | Uniprot | |
| T133 | Phosphorylation | Uniprot | |
| K140 | Ubiquitination | Uniprot | |
| T145 | Phosphorylation | Uniprot | |
| K168 | Methylation | Uniprot | |
| K168 | Sumoylation | Uniprot | |
| K168 | Ubiquitination | Uniprot | |
| S178 | Phosphorylation | Uniprot | |
| K208 | Sumoylation | Uniprot | |
| K208 | Ubiquitination | Uniprot | |
| Y213 | Phosphorylation | Uniprot | |
| K215 | Sumoylation | Uniprot | |
| K215 | Ubiquitination | Uniprot | |
| K216 | Ubiquitination | Uniprot | |
| S223 | Phosphorylation | Uniprot | |
| T224 | Phosphorylation | Uniprot | |
| S234 | Phosphorylation | Uniprot | |
| S239 | Phosphorylation | Uniprot | |
| K247 | Ubiquitination | Uniprot | |
| S250 | Phosphorylation | Uniprot | |
| S254 | Phosphorylation | Uniprot | |
| Y256 | Phosphorylation | Uniprot | |
| K265 | Ubiquitination | Uniprot | |
| T272 | Phosphorylation | Uniprot | |
| S273 | Phosphorylation | Uniprot | |
| T275 | Phosphorylation | Uniprot | |
| T286 | Phosphorylation | Uniprot | |
| S292 | Phosphorylation | Uniprot | |
| S294 | Phosphorylation | Uniprot | |
| T302 | Phosphorylation | Uniprot | |
| S312 | Phosphorylation | Uniprot | |
| S315 | Phosphorylation | Uniprot | |
| K317 | Ubiquitination | Uniprot | |
| T323 | Phosphorylation | Uniprot | |
| T327 | Phosphorylation | Uniprot | |
| S343 | Phosphorylation | Uniprot | |
| K370 | Ubiquitination | Uniprot | |
| S371 | Phosphorylation | Uniprot | |
| T379 | Phosphorylation | Uniprot | |
| Y380 | Phosphorylation | Uniprot | |
| S382 | Phosphorylation | Uniprot | |
| Y391 | Phosphorylation | P12931 (SRC) | Uniprot |
| S395 | Phosphorylation | Uniprot | |
| S397 | Phosphorylation | Uniprot | |
| K398 | Ubiquitination | Uniprot |
研究背景
Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
Expressed in a defined zone of basal keratinocytes in the deep outer root sheath of hair follicles. Also observed in sweat gland and mammary gland ductal and secretory cells, bile ducts, gastrointestinal tract, bladder urothelium, oral epithelia, esophagus, ectocervical epithelium (at protein level). Expressed in epidermal basal cells, in nipple epidermis and a defined region of the hair follicle. Also seen in a subset of vascular wall cells in both the veins and artery of human umbilical cord, and in umbilical cord vascular smooth muscle. Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma in structures that contain dystrophin and spectrin.
Heterotetramer of two type I and two type II keratins. Interacts with PNN and the actin-binding domain of DMD. Interacts with HCV core protein.
(Microbial infection) Interacts with hepatitis C virus/HCV core protein.
This keratin differs from all other IF proteins in lacking the C-terminal tail domain.
Belongs to the intermediate filament family.
研究领域
· Organismal Systems > Endocrine system > Estrogen signaling pathway. (View pathway)
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