产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
展开/折叠
Alpha E-catenin; Cadherin associated protein 102kDa; Cadherin associated protein; Cadherin-associated protein; CAP 102; CAP102; Catenin (cadherin associated protein) alpha 1 102kDa; Catenin (cadherin associated protein), alpha 1, 102kDa; Catenin alpha 1; Catenin alpha-1; CTNA1_HUMAN; CTNNA 1; Ctnna1; FLJ36832; FLJ52416; MDPT2; NY REN 13 antigen; OTTHUMP00000224141; OTTHUMP00000224147; Renal carcinoma antigen NY REN 13; Renal carcinoma antigen NY-REN-13;
抗原和靶标
- P35221 CTNA1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MTAVHAGNINFKWDPKSLEIRTLAVERLLEPLVTQVTTLVNTNSKGPSNKKRGRSKKAHVLAASVEQATENFLEKGDKIAKESQFLKEELVAAVEDVRKQGDLMKAAAGEFADDPCSSVKRGNMVRAARALLSAVTRLLILADMADVYKLLVQLKVVEDGILKLRNAGNEQDLGIQYKALKPEVDKLNIMAAKRQQELKDVGHRDQMAAARGILQKNVPILYTASQACLQHPDVAAYKANRDLIYKQLQQAVTGISNAAQATASDDASQHQGGGGGELAYALNNFDKQIIVDPLSFSEERFRPSLEERLESIISGAALMADSSCTRDDRRERIVAECNAVRQALQDLLSEYMGNAGRKERSDALNSAIDKMTKKTRDLRRQLRKAVMDHVSDSFLETNVPLLVLIEAAKNGNEKEVKEYAQVFREHANKLIEVANLACSISNNEEGVKLVRMSASQLEALCPQVINAALALAAKPQSKLAQENMDLFKEQWEKQVRVLTDAVDDITSIDDFLAVSENHILEDVNKCVIALQEKDVDGLDRTAGAIRGRAARVIHVVTSEMDNYEPGVYTEKVLEATKLLSNTVMPRFTEQVEAAVEALSSDPAQPMDENEFIDASRLVYDGIRDIRKAVLMIRTPEELDDSDFETEDFDVRSRTSVQTEDDQLIAGQSARAIMAQLPQEQKAKIAEQVASFQEEKSKLDAEVSKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTSDVISAAKKIAEAGSRMDKLGRTIADHCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELVVSGVDSAMSLIQAAKNLMNAVVQTVKASYVASTKYQKSQGMASLNLPAVSWKMKAPEKKPLVKREKQDETQTKIKRASQKKHVNPVQALSEFKAMDSI
翻译修饰 - P35221 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T2 | Phosphorylation | Uniprot | |
| K12 | Ubiquitination | Uniprot | |
| K16 | Ubiquitination | Uniprot | |
| T38 | Phosphorylation | Uniprot | |
| T42 | Phosphorylation | Uniprot | |
| S44 | Phosphorylation | Uniprot | |
| K45 | Ubiquitination | Uniprot | |
| K50 | Ubiquitination | Uniprot | |
| K57 | Ubiquitination | Uniprot | |
| K75 | Ubiquitination | Uniprot | |
| K81 | Ubiquitination | Uniprot | |
| S83 | Phosphorylation | Uniprot | |
| K87 | Ubiquitination | Uniprot | |
| S118 | Phosphorylation | Uniprot | |
| Y148 | Phosphorylation | Uniprot | |
| K163 | Ubiquitination | Uniprot | |
| R165 | Methylation | Uniprot | |
| Y177 | Phosphorylation | Uniprot | |
| K178 | Ubiquitination | Uniprot | |
| K181 | Ubiquitination | Uniprot | |
| K186 | Acetylation | Uniprot | |
| K186 | Ubiquitination | Uniprot | |
| K193 | Acetylation | Uniprot | |
| K193 | Ubiquitination | Uniprot | |
| K199 | Ubiquitination | Uniprot | |
| K216 | Ubiquitination | Uniprot | |
| Y222 | Phosphorylation | Uniprot | |
| T223 | Phosphorylation | Uniprot | |
| Y237 | Phosphorylation | Uniprot | |
| K238 | Ubiquitination | Uniprot | |
| Y245 | Phosphorylation | Uniprot | |
| K246 | Ubiquitination | Uniprot | |
| S264 | Phosphorylation | Uniprot | |
| S268 | Phosphorylation | Uniprot | |
| Y280 | Phosphorylation | Uniprot | |
| S295 | Phosphorylation | Uniprot | |
| S297 | Phosphorylation | Uniprot | |
| S304 | Phosphorylation | Uniprot | |
| S311 | Phosphorylation | Uniprot | |
| S323 | Phosphorylation | Uniprot | |
| S361 | Phosphorylation | Uniprot | |
| S366 | Phosphorylation | Uniprot | |
| K370 | Ubiquitination | Uniprot | |
| T372 | Phosphorylation | Uniprot | |
| K384 | Ubiquitination | Uniprot | |
| S393 | Phosphorylation | Uniprot | |
| K414 | Ubiquitination | Uniprot | |
| K417 | Ubiquitination | Uniprot | |
| Y419 | Phosphorylation | Uniprot | |
| K429 | Ubiquitination | Uniprot | |
| S439 | Phosphorylation | Uniprot | |
| K448 | Ubiquitination | Uniprot | |
| S453 | Phosphorylation | Uniprot | |
| S455 | Phosphorylation | Uniprot | |
| S477 | Phosphorylation | Uniprot | |
| K478 | Ubiquitination | Uniprot | |
| K493 | Ubiquitination | Uniprot | |
| T506 | Phosphorylation | Uniprot | |
| S507 | Phosphorylation | Uniprot | |
| K533 | Ubiquitination | Uniprot | |
| T541 | Phosphorylation | Uniprot | |
| Y563 | Phosphorylation | Uniprot | |
| K577 | Ubiquitination | Uniprot | |
| Y619 | Phosphorylation | Uniprot | |
| T634 | Phosphorylation | Uniprot | |
| S641 | Phosphorylation | P68400 (CSNK2A1) | Uniprot |
| T645 | Phosphorylation | Uniprot | |
| S652 | Phosphorylation | Uniprot | |
| T654 | Phosphorylation | Uniprot | |
| S655 | Phosphorylation | Uniprot | |
| T658 | Phosphorylation | Uniprot | |
| S668 | Phosphorylation | Uniprot | |
| K681 | Ubiquitination | Uniprot | |
| K683 | Ubiquitination | Uniprot | |
| S690 | Phosphorylation | Uniprot | |
| K695 | Ubiquitination | Uniprot | |
| S696 | Phosphorylation | Uniprot | |
| K737 | Ubiquitination | Uniprot | |
| S744 | Phosphorylation | Uniprot | |
| K747 | Acetylation | Uniprot | |
| K747 | Ubiquitination | Uniprot | |
| S754 | Phosphorylation | Uniprot | |
| K758 | Ubiquitination | Uniprot | |
| C767 | S-Nitrosylation | Uniprot | |
| S770 | Phosphorylation | Uniprot | |
| C772 | S-Nitrosylation | Uniprot | |
| K773 | Ubiquitination | Uniprot | |
| Y779 | Phosphorylation | Uniprot | |
| K797 | Ubiquitination | Uniprot | |
| Y837 | Phosphorylation | Uniprot | |
| K842 | Acetylation | Uniprot | |
| K842 | Ubiquitination | Uniprot | |
| S846 | Phosphorylation | Uniprot | |
| S851 | Phosphorylation | Uniprot | |
| S858 | Phosphorylation | Uniprot | |
| S886 | Phosphorylation | Uniprot | |
| S898 | Phosphorylation | Uniprot | |
| K901 | Methylation | Uniprot | |
| K901 | Ubiquitination | Uniprot | |
| S905 | Phosphorylation | Uniprot |
研究背景
Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.
Sumoylated.
Phosphorylation seems to contribute to the strength of cell-cell adhesion rather than to the basic capacity for cell-cell adhesion.
Cytoplasm>Cytoskeleton. Cell junction>Adherens junction. Cell membrane>Peripheral membrane protein>Cytoplasmic side. Cell junction.
Note: Found at cell-cell boundaries and probably at cell-matrix boundaries.
Cell membrane>Peripheral membrane protein>Cytoplasmic side.
Expressed ubiquitously in normal tissues.
Monomer and homodimer; the monomer preferentially binds to CTNNB1 and the homodimer to actin. Binds AFDN and F-actin. Possible component of an E-cadherin/ catenin adhesion complex together with E-cadherin/CDH1 and beta-catenin/CTNNB1 or gamma-catenin/JUP; the complex is located to adherens junctions. The stable association of CTNNA1 is controversial as CTNNA1 was shown not to bind to F-actin when assembled in the complex. Alternatively, the CTNNA1-containing complex may be linked to F-actin by other proteins such as LIMA1. Interacts with ARHGAP21 and with AJUBA. Interacts with LIMA1 (By similarity). Interacts with vinculin/VCL. Component of an cadherin:catenin adhesion complex composed of at least of CDH26, beta-catenin/CTNNB1, alpha-catenin/CTNNA1 and p120 catenin/CTNND1.
Belongs to the vinculin/alpha-catenin family.
研究领域
· Cellular Processes > Cellular community - eukaryotes > Adherens junction. (View pathway)
· Environmental Information Processing > Signal transduction > Hippo signaling pathway. (View pathway)
· Human Diseases > Infectious diseases: Bacterial > Bacterial invasion of epithelial cells.
· Human Diseases > Cancers: Overview > Pathways in cancer. (View pathway)
· Human Diseases > Cancers: Specific types > Endometrial cancer. (View pathway)
· Human Diseases > Cancers: Specific types > Gastric cancer. (View pathway)
· Human Diseases > Cardiovascular diseases > Arrhythmogenic right ventricular cardiomyopathy (ARVC).
· Organismal Systems > Immune system > Leukocyte transendothelial migration. (View pathway)
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