产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
展开/折叠
FAKD1_HUMAN; FAST kinase domain containing protein 1; FAST kinase domain-containing protein 1; FAST kinase domains 1; FASTKD1; FLJ21901; KIAA1800; OTTHUMP00000207008; OTTHUMP00000207010;
抗原和靶标
Expression detected in spleen, thymus, testis, ovary, colon, heart, smooth muscle, kidney, brain, lung, liver and white adipose tissue with highest expression in heart.
- Q53R41 FAKD1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MKKTPVFLESLVTNMLRLRAICPFSWRVFQFRPISCEPLIIQMNKCTDEEQMFGFIERNKAILSEKQVGCAFDMLWKLQKQKTSLLKNAEYVRDHPQFLTLHNLATNKFKLMNDDTLVNVLYVTQQFAGEAHDPLVEALVTEAWRRLERFDIKLLSEFSSCLADQHLYFSPLMGKIADIVHRNLETTQDLSSLSVLMVNISSLISRHFQQQLVNKTELLFDTIDSSEVNVAKSIAKFLRNVRYRYQPLLERCNNVFLSNVDHLDLDSISKILSVYKFLQFNSFEFIIMAKKKLTEMIPLCNHPASFVKLFVALGPIAGPEEKKQLKSTMLLMSEDLTGEQALAVLGAMGDMESRNSCLIKRVTSVLHKHLDGYKPLELLKITQELTFLHFQRKEFFAKLRELLLSYLKNSFIPTEVSVLVRAISLLPSPHLDEVGISRIEAVLPQCDLNNLSSFATSVLRWIQHDHMYLDNMTAKQLKLLQKLDHYGRQRLQHSNSLDLLRKELKSLKGNTFPESLLEEMIATLQHFMDDINYINVGEIASFISSTDYLSTLLLDRIASVAVQQIEKIHPFTIPAIIRPFSVLNYDPPQRDEFLGTCVQHLNSYLGILDPFILVFLGFSLATLEYFPEDLLKAIFNIKFLARLDSQLEILSPSRSARVQFHLMELNRSVCLECPEFQIPWFHDRFCQQYNKGIGGMDGTQQQIFKMLAEVLGGINCVKASVLTPYYHKVDFECILDKRKKPLPYGSHNIALGQLPEMPWESNIEIVGSRLPPGAERIALEFLDSKALCRNIPHMKGKSAMKKRHLEILGYRVIQISQFEWNSMALSTKDARMDYLRECIFGEVKSCL
翻译修饰 - Q53R41 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K60 | Ubiquitination | Uniprot | |
| T83 | Phosphorylation | Uniprot | |
| K87 | Ubiquitination | Uniprot | |
| Y122 | Phosphorylation | Uniprot | |
| T124 | Phosphorylation | Uniprot | |
| Y168 | Phosphorylation | Uniprot | |
| S170 | Phosphorylation | Uniprot | |
| S194 | Phosphorylation | Uniprot | |
| S202 | Phosphorylation | Uniprot | |
| S305 | Phosphorylation | Uniprot | |
| K360 | Acetylation | Uniprot | |
| K374 | Ubiquitination | Uniprot | |
| S405 | Phosphorylation | Uniprot | |
| Y406 | Phosphorylation | Uniprot | |
| K478 | Ubiquitination | Uniprot | |
| K482 | Ubiquitination | Uniprot | |
| Y486 | Phosphorylation | Uniprot | |
| S496 | Phosphorylation | Uniprot | |
| T546 | Phosphorylation | Uniprot | |
| T551 | Phosphorylation | Uniprot | |
| K691 | Ubiquitination | Uniprot | |
| Y726 | Phosphorylation | Uniprot | |
| K728 | Ubiquitination | Uniprot | |
| K737 | Ubiquitination | Uniprot | |
| K785 | Ubiquitination | Uniprot | |
| Y810 | Phosphorylation | Uniprot | |
| K844 | Ubiquitination | Uniprot |
研究背景
Involved in the down-regulation of mitochondrial MT-ND3 mRNA levels which leads to decreased respiratory complex I abundance and activity.
Mitochondrion.
Note: Preferentially localizes to mitochondrial RNA granules, platforms for post-transcriptional RNA modification and ribosome assembly (PubMed:28335001).
Expression detected in spleen, thymus, testis, ovary, colon, heart, smooth muscle, kidney, brain, lung, liver and white adipose tissue with highest expression in heart.
The RAP domain is essential to regulate MT-ND3 mRNA levels.
Belongs to the FAST kinase family.
限制条款
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