产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
展开/折叠
bHLHe37; Class E basic helix-loop-helix protein 37; MODED; mycn; MYCN_HUMAN; N myc; N myc proto oncogene protein; N-myc proto-oncogene protein; Neuroblastoma derived v myc avian myelocytomatosis viral related oncogene; Neuroblastoma MYC oncogene; NMYC; NMYC proto oncogene protein; ODED; Oncogene NMYC; pp65/67; V myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog; v myc avian myelocytomatosis viral related oncogene neuroblastoma derived; v myc myelocytomatosis viral related oncogene neuroblastoma derived;
抗原和靶标
Expressed in the neuronal cells of the cerebrum, neuroblastomas and thyroid tumors (at protein level).
- P04198 MYCN_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPSCSTSTMPGMICKNPDLEFDSLQPCFYPDEDDFYFGGPDSTPPGEDIWKKFELLPTPPLSPSRGFAEHSSEPPSWVTEMLLENELWGSPAEEDAFGLGGLGGLTPNPVILQDCMWSGFSAREKLERAVSEKLQHGRGPPTAGSTAQSPGAGAASPAGRGHGGAAGAGRAGAALPAELAHPAAECVDPAVVFPFPVNKREPAPVPAAPASAPAAGPAVASGAGIAAPAGAPGVAPPRPGGRQTSGGDHKALSTSGEDTLSDSDDEDDEEEDEEEEIDVVTVEKRRSSSNTKAVTTFTITVRPKNAALGPGRAQSSELILKRCLPIHQQHNYAAPSPYVESEDAPPQKKIKSEASPRPLKSVIPPKAKSLSPRNSDSEDSERRRNHNILERQRRNDLRSSFLTLRDHVPELVKNEKAAKVVILKKATEYVHSLQAEEHQLLLEKEKLQARQQQLLKKIEHARTC
翻译修饰 - P04198 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S3 | Phosphorylation | Uniprot | |
| S5 | Phosphorylation | Uniprot | |
| T6 | Phosphorylation | Uniprot | |
| S7 | Phosphorylation | Uniprot | |
| T8 | Phosphorylation | Uniprot | |
| K52 | Ubiquitination | Uniprot | |
| T58 | Phosphorylation | Uniprot | |
| S62 | Phosphorylation | P42345 (MTOR) | Uniprot |
| S64 | Phosphorylation | Uniprot | |
| R65 | Methylation | Uniprot | |
| K133 | Acetylation | Uniprot | |
| S156 | Phosphorylation | Uniprot | |
| R238 | Methylation | Uniprot | |
| R242 | Methylation | Uniprot | |
| S261 | Phosphorylation | P68400 (CSNK2A1) , P19784 (CSNK2A2) | Uniprot |
| S263 | Phosphorylation | P19784 (CSNK2A2) , P68400 (CSNK2A1) | Uniprot |
| K321 | Ubiquitination | Uniprot | |
| S355 | Phosphorylation | Uniprot |
研究背景
Positively regulates the transcription of MYCNOS in neuroblastoma cells.
Phosphorylated by GSK3-beta which may promote its degradation. Phosphorylated by AURKA.
Nucleus.
Expressed in the neuronal cells of the cerebrum, neuroblastomas and thyroid tumors (at protein level).
Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with KDM5A, KDM5B and HUWE1. Interacts with MYCNOS. Interacts with AURKA; interaction is phospho-independent and triggers AURKA activation; AURKA competes with FBXW7 for binding to unphosphorylated MYCN but not for binding to unphosphorylated MYCN. Interacts with FBXW7; FBXW7 competes with AURKA for binding to unphosphorylated MYCN but not for binding to phosphorylated MYCN.
研究领域
· Human Diseases > Cancers: Overview > Transcriptional misregulation in cancer.
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