AFfirm™ PFKP Mouse Monoclonal Antibody - #BF9303
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
展开/折叠
1200015H23Rik; 6 phosphofructokinase type C; 6 phosphofructokinase, platelet type; 6-phosphofructokinase; 6-phosphofructokinase type C; 9330125N24Rik; FLJ40226; K6PP; K6PP_HUMAN; MGC105718; PFK C; PFK, fibroblast type; PFK-C; PFKF; PFKP; Phosphofructo 1 kinase isozyme C; Phosphofructo-1-kinase isozyme C; Phosphofructokinase 1; Phosphofructokinase platelet; Phosphohexokinase; platelet type;
抗原和靶标
- Q01813 PFKAP_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDADDSRAPKGSLRKFLEHLSGAGKAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGGSNIAEADWESVSSILQVGGTIIGSARCQAFRTREGRLKAACNLLQRGITNLCVIGGDGSLTGANLFRKEWSGLLEELARNGQIDKEAVQKYAYLNVVGMVGSIDNDFCGTDMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEEGWEEQMCVKLSENRARKKRLNIIIVAEGAIDTQNKPITSEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEATPDTPACVVSLNGNHAVRLPLMECVQMTQDVQKAMDERRFQDAVRLRGRSFAGNLNTYKRLAIKLPDDQIPKTNCNVAVINVGAPAAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGTKRVLPGKYLEEIATQMRTHSINALLIIGGFEAYLGLLELSAAREKHEEFCVPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRIKQSASGTKRRVFIIETMGGYCGYLANMGGLAAGADAAYIFEEPFDIRDLQSNVEHLTEKMKTTIQRGLVLRNESCSENYTTDFIYQLYSEEGKGVFDCRKNVLGHMQQGGAPSPFDRNFGTKISARAMEWITAKLKEARGRGKKFTTDDSICVLGISKRNVIFQPVAELKKQTDFEHRIPKEQWWLKLRPLMKILAKYKASYDVSDSGQLEHVQPWSV
翻译修饰 - Q01813 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| M1 | Acetylation | Uniprot | |
| S6 | Phosphorylation | Uniprot | |
| K10 | Ubiquitination | Uniprot | |
| S12 | Phosphorylation | Uniprot | |
| K15 | Ubiquitination | Uniprot | |
| S21 | Phosphorylation | Uniprot | |
| K25 | Ubiquitination | Uniprot | |
| Y52 | Phosphorylation | Uniprot | |
| Y64 | Phosphorylation | Uniprot | |
| K109 | Acetylation | Uniprot | |
| K109 | Methylation | Uniprot | |
| K109 | Ubiquitination | Uniprot | |
| K139 | Ubiquitination | Uniprot | |
| S142 | Phosphorylation | Uniprot | |
| K156 | Acetylation | Uniprot | |
| K156 | Ubiquitination | Uniprot | |
| T211 | Phosphorylation | Uniprot | |
| K287 | Ubiquitination | Uniprot | |
| K289 | Ubiquitination | Uniprot | |
| R310 | Methylation | Uniprot | |
| T313 | Phosphorylation | Uniprot | |
| R319 | Methylation | Uniprot | |
| S386 | Phosphorylation | Uniprot | |
| T393 | Phosphorylation | Uniprot | |
| K395 | Acetylation | Uniprot | |
| K395 | Ubiquitination | Uniprot | |
| K400 | Ubiquitination | Uniprot | |
| C411 | S-Nitrosylation | Uniprot | |
| Y447 | Phosphorylation | Uniprot | |
| K455 | Ubiquitination | Uniprot | |
| K459 | Ubiquitination | Uniprot | |
| K480 | Acetylation | Uniprot | |
| K480 | Ubiquitination | Uniprot | |
| K486 | Acetylation | Uniprot | |
| K486 | Ubiquitination | Uniprot | |
| Y487 | Phosphorylation | Uniprot | |
| K567 | Ubiquitination | Uniprot | |
| K574 | Acetylation | Uniprot | |
| Y586 | Phosphorylation | Uniprot | |
| K625 | Ubiquitination | Uniprot | |
| K627 | Ubiquitination | Uniprot | |
| Y645 | Phosphorylation | Uniprot | |
| Y651 | Phosphorylation | Uniprot | |
| Y654 | Phosphorylation | Uniprot | |
| K666 | Ubiquitination | Uniprot | |
| K688 | Acetylation | Uniprot | |
| K688 | Ubiquitination | Uniprot | |
| K700 | Acetylation | Uniprot | |
| K724 | Ubiquitination | Uniprot | |
| K736 | Acetylation | Uniprot | |
| K736 | Methylation | Uniprot | |
| K736 | Ubiquitination | Uniprot | |
| K737 | Methylation | Uniprot | |
| K737 | Ubiquitination | Uniprot | |
| K747 | Acetylation | Uniprot | |
| K747 | Ubiquitination | Uniprot | |
| K753 | Ubiquitination | Uniprot | |
| K759 | Ubiquitination | Uniprot | |
| K765 | Ubiquitination | Uniprot | |
| S783 | Phosphorylation | Uniprot |
研究背景
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
GlcNAcylation decreases enzyme activity.
Cytoplasm.
Homo- and heterotetramers (By similarity). Phosphofructokinase (PFK) enzyme functions as a tetramer composed of different combinations of 3 types of subunits, called PFKM (where M stands for Muscle), PFKL (Liver) and PFKP (Platelet). The composition of the PFK tetramer differs according to the tissue type it is present in. In muscles, it is composed of 4 PFKM subunits (also called M4). In the liver, the predominant form is a tetramer of PFKL subunits (L4). In erythrocytes, both PFKM and PFKL subunits randomly tetramerize to form M4, L4 and other combinations (ML3, M2L2, M3L). In platelets, brain and fibroblasts, PFK contains a higher proportion of PFKP subunits. The kinetic and regulatory properties of the tetrameric enzyme are dependent on the subunit composition, hence can vary across tissues (Probable).
Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.
研究领域
· Environmental Information Processing > Signal transduction > AMPK signaling pathway. (View pathway)
· Genetic Information Processing > Folding, sorting and degradation > RNA degradation.
· Human Diseases > Cancers: Overview > Central carbon metabolism in cancer. (View pathway)
· Metabolism > Carbohydrate metabolism > Glycolysis / Gluconeogenesis.
· Metabolism > Carbohydrate metabolism > Pentose phosphate pathway.
· Metabolism > Carbohydrate metabolism > Fructose and mannose metabolism.
· Metabolism > Carbohydrate metabolism > Galactose metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
· Metabolism > Global and overview maps > Carbon metabolism.
· Metabolism > Global and overview maps > Biosynthesis of amino acids.
· Organismal Systems > Endocrine system > Thyroid hormone signaling pathway. (View pathway)
限制条款
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