产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
展开/折叠
docking protein 4; Downstream of tyrosine kinase 4; FLJ10488; insulin receptor substrate 5; IRS5;
抗原和靶标
Widely expressed. High expression in skeletal muscle, heart, kidney and liver. Weaker expression in spleen, lung and small intestine, brain, heart and. Expressed in both resting and activated peripheral blood T-cells.
- Q8TEW6 DOK4_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MATNFSDIVKQGYVKMKSRKLGIYRRCWLVFRKSSSKGPQRLEKYPDEKSVCLRGCPKVTEISNVKCVTRLPKETKRQAVAIIFTDDSARTFTCDSELEAEEWYKTLSVECLGSRLNDISLGEPDLLAPGVQCEQTDRFNVFLLPCPNLDVYGECKLQITHENIYLWDIHNPRVKLVSWPLCSLRRYGRDATRFTFEAGRMCDAGEGLYTFQTQEGEQIYQRVHSATLAIAEQHKRVLLEMEKNVRLLNKGTEHYSYPCTPTTMLPRSAYWHHITGSQNIAEASSYAGEGYGAAQASSETDLLNRFILLKPKPSQGDSSEAKTPSQ
翻译修饰 - Q8TEW6 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y13 | Phosphorylation | Uniprot | |
| S35 | Phosphorylation | Uniprot | |
| K66 | Ubiquitination | Uniprot | |
| Y104 | Phosphorylation | Uniprot | |
| T106 | Phosphorylation | Uniprot | |
| Y165 | Phosphorylation | Uniprot | |
| Y220 | Phosphorylation | Uniprot | |
| S225 | Phosphorylation | Uniprot | |
| Y255 | Phosphorylation | Uniprot | |
| S256 | Phosphorylation | Uniprot | |
| Y257 | Phosphorylation | Uniprot | |
| T260 | Phosphorylation | Uniprot | |
| S314 | Phosphorylation | Uniprot | |
| S319 | Phosphorylation | Uniprot | |
| T323 | Phosphorylation | Uniprot |
研究背景
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway (By similarity). Putative link with downstream effectors of RET in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells.
Phosphorylated on tyrosine residues in response to insulin, IGF1 or RET stimulation.
Widely expressed. High expression in skeletal muscle, heart, kidney and liver. Weaker expression in spleen, lung and small intestine, brain, heart and. Expressed in both resting and activated peripheral blood T-cells.
Interacts with RET and TEK/TIE2. Interaction with RET is mediated through the PTB domain and requires phosphorylation of RET 'Tyr-1062' (By similarity).
PTB domain mediates receptor interaction.
Belongs to the DOK family. Type B subfamily.
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