AFfirm™ EGR2 Mouse Monoclonal Antibody - #BF9313

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产品: EGR2 小鼠 单克隆 抗体
货号: BF9313
描述: Mouse monoclonal antibody to EGR2
应用: WB
反应: Human
预测: Mouse, Rat, Pig, Horse, Sheep, Rabbit, Dog, Xenopus
分子量: 50kDa; 50kD(Calculated).
蛋白号: P11161

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 100ul RMB¥ 1150 2300 现货

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产品描述

来源:
Mouse
应用:
WB 1:500-1:3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human
克隆:
Monoclonal [AFfirm9313]
特异性:
EGR2 Mouse Monoclonal Antibody detects endogenous levels of total EGR2.
偶联:
Unconjugated.
纯化:
Affinity-chromatography.
保存:
Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

AT225; AT591; CMT1D; CMT4E; E3 SUMO-protein ligase EGR2; Early growth response 1; Early growth response 2; Early growth response protein 1; Early growth response protein 2; EGR1; EGR2; G0S30; KROX-24; KROX20; Nerve growth factor-induced protein A; NGFI A; NGFI-A; TIS8; Transcription factor ETR103; Transcription factor Zif268; ZIF-268; Zinc finger protein 225; Zinc finger protein Krox-20; Zinc finger protein Krox-24; ZNF225;

抗原和靶标

免疫原:
Uniprot:

P11161(EGR2_HUMAN) >>Visit HPA database.

基因/基因ID:
EGR2(1959)
描述:
The early growth response protein 2 is a transcription factor with three tandem C2H2-type zinc fingers. Mutations in this gene are associated with the autosomal dominant Charcot-Marie-Tooth disease, type 1.
序列:
MMTAKAVDKIPVTLSGFVHQLSDNIYPVEDLAATSVTIFPNAELGGPFDQMNGVAGDGMINIDMTGEKRSLDLPYPSSFAPVSAPRNQTFTYMGKFSIDPQYPGASCYPEGIINIVSAGILQGVTSPASTTASSSVTSASPNPLATGPLGVCTMSQTQPDLDHLYSPPPPPPPYSGCAGDLYQDPSAFLSAATTSTSSSLAYPPPPSYPSPKPATDPGLFPMIPDYPGFFPSQCQRDLHGTAGPDRKPFPCPLDTLRVPPPLTPLSTIRNFTLGGPSAGVTGPGASGGSEGPRLPGSSSAAAAAAAAAAYNPHHLPLRPILRPRKYPNRPSKTPVHERPYPCPAEGCDRRFSRSDELTRHIRIHTGHKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDYCGRKFARSDERKRHTKIHLRQKERKSSAPSASVPAPSTASCSGGVQPGGTLCSSNSSSLGGGPLAPCSSRTRTP

翻译修饰 - P11161 作为底物

Site PTM Type Enzyme
S70 Phosphorylation
Y75 Phosphorylation
S77 Phosphorylation
R257 Methylation
T263 Phosphorylation
R293 Methylation
T391 Phosphorylation
T393 Phosphorylation

研究背景

功能:

Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4.

E3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 own transcriptional activity.

翻译修饰:

Ubiquitinated by WWP2 leading to proteasomal degradation.

细胞定位:

Nucleus.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
亚基结构:

Interacts with HCFC1. Interacts with WWP2. Interacts with UBC9.

蛋白家族:

Belongs to the EGR C2H2-type zinc-finger protein family.

研究领域

· Human Diseases > Infectious diseases: Viral > Hepatitis B.

· Human Diseases > Infectious diseases: Viral > HTLV-I infection.

· Human Diseases > Cancers: Overview > Viral carcinogenesis.

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