AFfirm™ CDX2 Mouse Monoclonal Antibody - #BF9348

产品: CDX2 小鼠 单克隆 抗体
货号: BF9348
描述: Mouse monoclonal antibody to CDX2
应用: WB
反应: Human
预测: Mouse, Rat, Pig, Bovine, Sheep, Rabbit, Dog, Chicken
分子量: 36 KD; 34kD(Calculated).
蛋白号: Q99626

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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实验方案
WB Handbook
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产品描述

来源:
Mouse
应用:
WB 1:500-1:3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human
克隆:
Monoclonal [AFfirm9348]
特异性:
CDX2 Mouse Monoclonal Antibody detects endogenous levels of total CDX2.
偶联:
Unconjugated.
纯化:
Affinity-chromatography.
保存:
Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

Caudal type homeo box 2; Caudal type homeo box transcription factor 2; Caudal type homeobox 2; Caudal type homeobox protein 2; Caudal type homeobox transcription factor 2; Caudal-type homeobox protein 2; CDX 2; CDX 3; CDX-3; Cdx2; CDX2/AS; CDX2_HUMAN; CDX3; Homeobox protein CDX 2; Homeobox protein CDX-2;

抗原和靶标

免疫原:
Uniprot:

Q99626(CDX2_HUMAN) >>Visit HPA database.

基因/基因ID:
CDX2(1045)
序列:
MYVSYLLDKDVSMYPSSVRHSGGLNLAPQNFVSPPQYPDYGGYHVAAAAAAAANLDSAQSPGPSWPAAYGAPLREDWNGYAPGGAAAAANAVAHGLNGGSPAAAMGYSSPADYHPHHHPHHHPHHPAAAPSCASGLLQTLNPGPPGPAATAAAEQLSPGGQRRNLCEWMRKPAQQSLGSQVKTRTKDKYRVVYTDHQRLELEKEFHYSRYITIRRKAELAATLGLSERQVKIWFQNRRAKERKINKKKLQQQQQQQPPQPPPPPPQPPQPQPGPLRSVPEPLSPVSSLQASVPGSVPGVLGPTGGVLNPTVTQ

翻译修饰 - Q99626 作为底物

Site PTM Type Enzyme
S4 Phosphorylation
S60 Phosphorylation
S176 Phosphorylation
S226 Phosphorylation
S277 Phosphorylation
S283 Phosphorylation P24941 (CDK2) , Q16539 (MAPK14) , P49841 (GSK3B)
S287 Phosphorylation P24941 (CDK2) , Q16539 (MAPK14)
S291 Phosphorylation P24941 (CDK2) , Q16539 (MAPK14)
S295 Phosphorylation Q16539 (MAPK14)
T310 Phosphorylation
T312 Phosphorylation

研究背景

功能:

Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Binds preferentially to methylated DNA.

翻译修饰:

Phosphorylation of Ser-60 mediates the transactivation capacity.

细胞定位:

Nucleus.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
蛋白家族:

Belongs to the Caudal homeobox family.

研究领域

· Human Diseases > Cancers: Specific types > Gastric cancer.   (View pathway)

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