产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
展开/折叠
Deafness X linked 7; DFN7; FAEES3; Fatty acid ethyl ester synthase III; Glutathione S transferase pi 1; Glutathione S-transferase P; GST class-pi; GST3; Gstp1; GSTP1-1; GSTP1_HUMAN; GSTpi; PI;
抗原和靶标
- P09211 GSTP1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPPYTVVYFPVRGRCAALRMLLADQGQSWKEEVVTVETWQEGSLKASCLYGQLPKFQDGDLTLYQSNTILRHLGRTLGLYGKDQQEAALVDMVNDGVEDLRCKYISLIYTNYEAGKDDYVKALPGQLKPFETLLSQNQGGKTFIVGDQISFADYNLLDLLLIHEVLAPGCLDAFPLLSAYVGRLSARPKLKAFLASPEYVNLPINGNGKQ
翻译修饰 - P09211 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y4 | Phosphorylation | P00533 (EGFR) | Uniprot |
| Y8 | Phosphorylation | P00533 (EGFR) | Uniprot |
| S28 | Phosphorylation | Uniprot | |
| K30 | Sumoylation | Uniprot | |
| S43 | Phosphorylation | P24723 (PRKCH) | Uniprot |
| K45 | Methylation | Uniprot | |
| S47 | Phosphorylation | Uniprot | |
| C48 | S-Nitrosylation | Uniprot | |
| Y50 | Phosphorylation | Uniprot | |
| K55 | Acetylation | Uniprot | |
| K55 | Ubiquitination | Uniprot | |
| T62 | Phosphorylation | Uniprot | |
| Y64 | Phosphorylation | Uniprot | |
| Y80 | Phosphorylation | Uniprot | |
| K82 | Methylation | Uniprot | |
| K82 | Sumoylation | Uniprot | |
| K82 | Ubiquitination | Uniprot | |
| K103 | Acetylation | Uniprot | |
| K103 | Ubiquitination | Uniprot | |
| S106 | Phosphorylation | Uniprot | |
| Y109 | Phosphorylation | Uniprot | |
| T110 | Phosphorylation | Uniprot | |
| Y112 | Phosphorylation | Uniprot | |
| K116 | Acetylation | Uniprot | |
| K121 | Acetylation | Uniprot | |
| K121 | Ubiquitination | Uniprot | |
| K128 | Acetylation | Uniprot | |
| K128 | Ubiquitination | Uniprot | |
| T132 | Phosphorylation | Uniprot | |
| S135 | Phosphorylation | Uniprot | |
| K141 | Methylation | Uniprot | |
| K141 | Sumoylation | Uniprot | |
| S185 | Phosphorylation | P24723 (PRKCH) , P17252 (PRKCA) , P17612 (PRKACA) | Uniprot |
| K189 | Acetylation | Uniprot | |
| K189 | Ubiquitination | Uniprot | |
| K191 | Acetylation | Uniprot | |
| K191 | Ubiquitination | Uniprot | |
| S196 | Phosphorylation | Uniprot | |
| Y199 | Phosphorylation | P00533 (EGFR) | Uniprot |
| K209 | Acetylation | Uniprot | |
| K209 | Methylation | Uniprot | |
| K209 | Ubiquitination | Uniprot |
研究背景
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.
Cytoplasm. Mitochondrion. Nucleus.
Note: The 83 N-terminal amino acids function as un uncleaved transit peptide, and arginine residues within it are crucial for mitochondrial localization.
Homodimer. Interacts with CDK5.
Belongs to the GST superfamily. Pi family.
研究领域
· Human Diseases > Drug resistance: Antineoplastic > Platinum drug resistance.
· Human Diseases > Cancers: Overview > Pathways in cancer. (View pathway)
· Human Diseases > Cancers: Overview > Chemical carcinogenesis.
· Human Diseases > Cancers: Specific types > Prostate cancer. (View pathway)
· Human Diseases > Cancers: Specific types > Hepatocellular carcinoma. (View pathway)
· Metabolism > Metabolism of other amino acids > Glutathione metabolism.
· Metabolism > Xenobiotics biodegradation and metabolism > Metabolism of xenobiotics by cytochrome P450.
· Metabolism > Xenobiotics biodegradation and metabolism > Drug metabolism - cytochrome P450.
· Metabolism > Xenobiotics biodegradation and metabolism > Drug metabolism - other enzymes.
限制条款
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