产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
展开/折叠
A disintegrin and metalloproteinase domain 23; ADAM metallopeptidase domain 23; Disintegrin and metalloproteinase domain containing protein 23; MDC 3; MDC3; Metalloproteinase like disintegrin like and cysteine rich protein 3;
抗原和靶标
Highly expressed in the brain and weakly expressed in the heart. In the brain, expressed prominently in the amygdala, caudate nucleus, hypothalamus, thalamus, cerebral cortex and occipital pole.
- O75077 ADA23_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MKPPGSSSRQPPLAGCSLAGASCGPQRGPAGSVPASAPARTPPCRLLLVLLLLPPLAASSRPRAWGAAAPSAPHWNETAEKNLGVLADEDNTLQQNSSSNISYSNAMQKEITLPSRLIYYINQDSESPYHVLDTKARHQQKHNKAVHLAQASFQIEAFGSKFILDLILNNGLLSSDYVEIHYENGKPQYSKGGEHCYYHGSIRGVKDSKVALSTCNGLHGMFEDDTFVYMIEPLELVHDEKSTGRPHIIQKTLAGQYSKQMKNLTMERGDQWPFLSELQWLKRRKRAVNPSRGIFEEMKYLELMIVNDHKTYKKHRSSHAHTNNFAKSVVNLVDSIYKEQLNTRVVLVAVETWTEKDQIDITTNPVQMLHEFSKYRQRIKQHADAVHLISRVTFHYKRSSLSYFGGVCSRTRGVGVNEYGLPMAVAQVLSQSLAQNLGIQWEPSSRKPKCDCTESWGGCIMEETGVSHSRKFSKCSILEYRDFLQRGGGACLFNRPTKLFEPTECGNGYVEAGEECDCGFHVECYGLCCKKCSLSNGAHCSDGPCCNNTSCLFQPRGYECRDAVNECDITEYCTGDSGQCPPNLHKQDGYACNQNQGRCYNGECKTRDNQCQYIWGTKAAGSDKFCYEKLNTEGTEKGNCGKDGDRWIQCSKHDVFCGFLLCTNLTRAPRIGQLQGEIIPTSFYHQGRVIDCSGAHVVLDDDTDVGYVEDGTPCGPSMMCLDRKCLQIQALNMSSCPLDSKGKVCSGHGVCSNEATCICDFTWAGTDCSIRDPVRNLHPPKDEGPKGPSATNLIIGSIAGAILVAAIVLGGTGWGFKNVKKRRFDPTQQGPI
翻译修饰 - O75077 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y119 | Phosphorylation | Uniprot | |
| S127 | Phosphorylation | Uniprot | |
| Y129 | Phosphorylation | Uniprot | |
| T265 | Phosphorylation | Uniprot | |
| T352 | Phosphorylation | Uniprot | |
| T354 | Phosphorylation | Uniprot | |
| T393 | Phosphorylation | Uniprot | |
| Y396 | Phosphorylation | Uniprot | |
| Y403 | Phosphorylation | Uniprot | |
| T453 | Phosphorylation | Uniprot | |
| S473 | Phosphorylation | Uniprot | |
| Y707 | Phosphorylation | Uniprot |
研究背景
May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein.
Cell membrane>Single-pass type I membrane protein.
Secreted.
Highly expressed in the brain and weakly expressed in the heart. In the brain, expressed prominently in the amygdala, caudate nucleus, hypothalamus, thalamus, cerebral cortex and occipital pole.
Can bind to LGI1 and LGI4 (By similarity). Ligand for integrin alpha-V/beta-3.
A conserved motif AVN[ED]CD within the disintegrin-like domain could be involved in the binding to the integrin receptor.
限制条款
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