产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
展开/折叠
Chromosome 19 open reading frame 61; DKFZp564H1322; F17127_1; FLJ12886; Protein smg 9 homolog; Protein smg-9 homolog; Protein SMG9; SMG 9; smg9; SMG9_HUMAN; Suppressor with morphogenetic effect on genitalia protein 9,;
抗原和靶标
- Q9H0W8 SMG9_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSESGHSQPGLYGIERRRRWKEPGSGGPQNLSGPGGRERDYIAPWERERRDASEETSTSVMQKTPIILSKPPAERSKQPPPPTAPAAPPAPAPLEKPIVLMKPREEGKGPVAVTGASTPEGTAPPPPAAPAPPKGEKEGQRPTQPVYQIQNRGMGTAAPAAMDPVVGQAKLLPPERMKHSIKLVDDQMNWCDSAIEYLLDQTDVLVVGVLGLQGTGKSMVMSLLSANTPEEDQRTYVFRAQSAEMKERGGNQTSGIDFFITQERIVFLDTQPILSPSILDHLINNDRKLPPEYNLPHTYVEMQSLQIAAFLFTVCHVVIVVQDWFTDLSLYRFLQTAEMVKPSTPSPSHESSSSSGSDEGTEYYPHLVFLQNKARREDFCPRKLRQMHLMIDQLMAHSHLRYKGTLSMLQCNVFPGLPPDFLDSEVNLFLVPFMDSEAESENPPRAGPGSSPLFSLLPGYRGHPSFQSLVSKLRSQVMSMARPQLSHTILTEKNWFHYAARIWDGVRKSSALAEYSRLLA
翻译修饰 - Q9H0W8 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S2 | Acetylation | Uniprot | |
| S2 | Phosphorylation | Uniprot | |
| S4 | Phosphorylation | Uniprot | |
| S7 | Phosphorylation | Uniprot | |
| Y12 | Phosphorylation | Uniprot | |
| K21 | Methylation | Uniprot | |
| S25 | Phosphorylation | Uniprot | |
| S32 | Phosphorylation | Uniprot | |
| Y41 | Phosphorylation | Uniprot | |
| S53 | Phosphorylation | Uniprot | |
| T64 | Phosphorylation | Uniprot | |
| S69 | Phosphorylation | Uniprot | |
| T114 | Phosphorylation | Uniprot | |
| S117 | Phosphorylation | Uniprot | |
| T118 | Phosphorylation | Uniprot | |
| T122 | Phosphorylation | Uniprot | |
| K137 | Ubiquitination | Uniprot | |
| T143 | Phosphorylation | Uniprot | |
| Y147 | Phosphorylation | Uniprot | |
| K170 | Ubiquitination | Uniprot | |
| R248 | Methylation | Uniprot | |
| K373 | Ubiquitination | Uniprot | |
| S451 | Phosphorylation | Uniprot | |
| K472 | Ubiquitination | Uniprot | |
| K508 | Ubiquitination | Uniprot |
研究背景
Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG8 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required for the efficient association between SMG1 and SMG8. Plays a role in brain, heart, and eye development (By similarity).
Phosphorylated by SMG1.
Component of the SMG1C complex composed of SMG1, SMG8 and SMG9. Self-associates to form homodimers and forms heterodimers with SMG8; these assembly forms may represent SMG1C intermediate forms.
Belongs to the SMG9 family.
限制条款
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