产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
展开/折叠
Antioxidant protein 1; AOP 1; AOP-1; AOP1; HBC189; MER5; MGC104387; MGC24293; mitochondrial; peroxiredoxin 3; Peroxiredoxin III; Peroxiredoxin-3; PRDX3; PRDX3_HUMAN; PRO1748; Protein MER5 homolog; PRX III; Prx-III; PRX3; SP 22; SP-22; SP22; Thioredoxin dependent peroxide reductase mitochondrial; Thioredoxin-dependent peroxide reductase;
抗原和靶标
- P30048 PRDX3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAAAVGRLLRASVARHVSAIPWGISATAALRPAACGRTSLTNLLCSGSSQAKLFSTSSSCHAPAVTQHAPYFKGTAVVNGEFKDLSLDDFKGKYLVLFFYPLDFTFVCPTEIVAFSDKANEFHDVNCEVVAVSVDSHFSHLAWINTPRKNGGLGHMNIALLSDLTKQISRDYGVLLEGSGLALRGLFIIDPNGVIKHLSVNDLPVGRSVEETLRLVKAFQYVETHGEVCPANWTPDSPTIKPSPAASKEYFQKVNQ
翻译修饰 - P30048 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y71 | Phosphorylation | Uniprot | |
| K83 | Acetylation | Uniprot | |
| K83 | Ubiquitination | Uniprot | |
| S86 | Phosphorylation | Uniprot | |
| K91 | Acetylation | Uniprot | |
| K91 | Ubiquitination | Uniprot | |
| K93 | Acetylation | Uniprot | |
| T146 | Phosphorylation | Q5S007 (LRRK2) | Uniprot |
| K149 | Ubiquitination | Uniprot | |
| Y172 | Phosphorylation | Uniprot | |
| S179 | Phosphorylation | Uniprot | |
| K196 | Acetylation | Uniprot | |
| K196 | Sumoylation | Uniprot | |
| K196 | Ubiquitination | Uniprot | |
| S199 | Phosphorylation | Uniprot | |
| R207 | Methylation | Uniprot | |
| R214 | Methylation | Uniprot | |
| C229 | S-Nitrosylation | Uniprot | |
| T234 | Phosphorylation | Uniprot | |
| S237 | Phosphorylation | Uniprot | |
| K241 | Ubiquitination | Uniprot | |
| K248 | Acetylation | Uniprot | |
| K253 | Ubiquitination | Uniprot |
研究背景
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol.
Phosphorylated by LRRK2; phosphorylation reduces perodixase activity.
The enzyme can be inactivated by further oxidation of the cysteine sulfenic acid (C(P)-SOH) to sulphinic acid (C(P)-SO2H) and sulphonic acid (C(P)-SO3H) instead of its condensation to a disulfide bond.
Mitochondrion. Cytoplasm. Early endosome.
Note: Localizes to early endosomes in a RPS6KC1-dependent manner.
Homodimer; disulfide-linked, upon oxidation. 6 homodimers assemble to form a ring-like dodecamer. Interacts with NEK6. Interacts with LRRK2. Interacts with MAP3K13. Interacts with RPS6KC1 (via PX domain).
Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
限制条款
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