| 产品: | IST1 小鼠单克隆 抗体 |
| 货号: | BF9506 |
| 描述: | Mouse monoclonal antibody to IST1 |
| 应用: | ELISA(peptide) |
| 反应: | Human |
| 预测: | Mouse, Pig, Bovine, Horse, Sheep, Rabbit, Dog |
| 分子量: | 40 kDa(Observed); 40kD(Calculated). |
| 蛋白ID: | P53990 |
产品描述
展开/折叠
hIST1; Increased sodium tolerance 1; Increased sodium tolerance 1 homolog; IST1 homolog; IST1_HUMAN; KIAA0174; MAPK activating protein PM28; MGC117220; MGC128433; Putative MAPK-activating protein PM28;
抗原和靶标
A synthesized peptide derived from human IST1, corresponding to a region within the internal amino acids.
- P53990 IST1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLGSGFKAERLRVNLRLVINRLKLLEKKKTELAQKARKEIADYLAAGKDERARIRVEHIIREDYLVEAMEILELYCDLLLARFGLIQSMKELDSGLAESVSTLIWAAPRLQSEVAELKIVADQLCAKYSKEYGKLCRTNQIGTVNDRLMHKLSVEAPPKILVERYLIEIAKNYNVPYEPDSVVMAEAPPGVETDLIDVGFTDDVKKGGPGRGGSGGFTAPVGGPDGTVPMPMPMPMPSANTPFSYPLPKGPSDFNGLPMGTYQAFPNIHPPQIPATPPSYESVDDINADKNISSAQIVGPGPKPEASAKLPSRPADNYDNFVLPELPSVPDTLPTASAGASTSASEDIDFDDLSRRFEELKKKT
研究背景
ESCRT-III-like protein involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing. Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST.
Cytoplasmic vesicle. Cytoplasm>Cytoskeleton>Microtubule organizing center>Centrosome. Midbody. Nucleus envelope.
Note: Localizes to centrosome and midbody of dividing cells (PubMed:19129480, PubMed:19129479, PubMed:20719964). Colocalized with SPART to the ends of Flemming bodies during cytokinesis (PubMed:20719964). Localizes to the nuclear envelope during late anaphase (PubMed:26040712).
Belongs to the IST1 family.
研究领域
· Cellular Processes > Transport and catabolism > Endocytosis. (View pathway)
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