| 产品: | SH3GL2 小鼠单克隆 抗体 |
| 货号: | BF9579 |
| 描述: | Mouse monoclonal antibody to SH3GL2 |
| 应用: | ELISA(peptide) |
| 反应: | Human, Mouse |
| 预测: | Pig, Bovine, Horse, Sheep, Dog, Chicken, Xenopus |
| 分子量: | 39 KD(Observed); 40kD(Calculated). |
| 蛋白ID: | Q99962 |
产品描述
展开/折叠
bA335L15.1 (SH3 domain GRB2 like 2); CNSA2; EEN B1; EEN-B1; Endophilin 1; Endophilin A1; Endophilin A1 BAR domain; Endophilin-1; Endophilin-A1; FLJ20276; FLJ25015; OTTHUMP00000021084; SH3 domain containing GRB2 like protein 2; SH3 domain GRB2 like 2; SH3 domain protein 2A; SH3 domain-containing GRB2-like protein 2; SH3D2A; SH3G2_HUMAN; Sh3gl2; Sh3p4; SH3PA;
抗原和靶标
A synthesized peptide derived from human SH3GL2, corresponding to a region within the internal amino acids.
- Q99962 SH3G2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSVAGLKKQFHKATQKVSEKVGGAEGTKLDDDFKEMERKVDVTSRAVMEIMTKTIEYLQPNPASRAKLSMINTMSKIRGQEKGPGYPQAEALLAEAMLKFGRELGDDCNFGPALGEVGEAMRELSEVKDSLDIEVKQNFIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKKKRQGKIPDEELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSALVQAQLEYHKQAVQILQQVTVRLEERIRQASSQPRREYQPKPRMSLEFPTGDSTQPNGGLSHTGTPKPSGVQMDQPCCRALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPINYVEILVALPH
研究背景
Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes.
Cytoplasm. Membrane>Peripheral membrane protein. Early endosome. Cell junction>Synapse>Presynapse.
Brain, mostly in frontal cortex. Expressed at high level in fetal cerebellum.
An N-terminal amphipathic helix, the BAR domain and a second amphipathic helix inserted into helix 1 of the BAR domain (N-BAR domain) induce membrane curvature and bind curved membranes. The BAR domain dimer forms a rigid crescent shaped bundle of helices with the pair of second amphipathic helices protruding towards the membrane-binding surface.
Belongs to the endophilin family.
研究领域
· Cellular Processes > Transport and catabolism > Endocytosis. (View pathway)
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