产品描述

货号:
BF6226
简介:
Enoticumab (REGN421, SAR153192) is an IgG1κ antibody targeting human Dll4. DLL4 is a ligand of the Notch signaling pathway and regulates fatty acid uptake through non-transcriptional regulation of macropinocytosis-dependent long-chain fatty acid uptake. Specific in vivo activity of Enoticumab in an ovarian xenograft model. EGN421 (2.5 mg/kg once weekly) resulted in 86% and 83% tumor growth inhibition in mouse subcutaneous TOV-112D or intraperitoneal A2780 human tumor xenograft models, respectively.
别名:

依诺苏单抗; REGN421

靶标:
DLL4
蛋白ID:
Q9NR61
基因ID:
54567
分子量:
146.48 kDa
应用:
FACS, ELISA, Functional assay
反应:
Human
CAS NO.:
1192578-27-0
运输方式:
Shipping with dry ice.
缓冲液:
Supplied as a 0.22 μm filtered solution in 100 mM Pro-Ac, 20 mM Arg, pH 5.0
储存条件:
Store at -80°C for 2 years. Aliquots should be stored at the same temperature after first use to avoid

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