Intetumumab - #BF6250
产品描述
货号:
BF6250
简介:
Intetumumab (CNTO 95) is a human monoclonal antibody targeting αv integrin, with a Kd value of 1-24 nM. Through high-affinity binding to αv integrin, Intetumumab inhibits its interaction with extracellular matrix proteins (such as vitronectin and fibronectin), thereby blocking the downstream focal adhesion kinase signaling pathway. This further inhibits the adhesion, migration and invasion of tumor cells as well as the proliferation of vascular endothelial cells, promotes cell apoptosis, and exerts anti-tumor and anti-angiogenic effects. Intetumumab can be used in research related to head and neck cancer, non-small cell lung cancer and uterine serous papillary carcinoma.
别名:
英妥木单抗; CNTO 95; Anti-Human CD51 Recombinant Antibody
靶标:
Integrin aV/ITGAV/CD51
蛋白ID:
P06756
基因ID:
3685,3688
分子量:
145.14 kDa
应用:
FACS, ELISA, Functional assay
反应:
Human
CAS NO.:
725735-28-4
运输方式:
Shipping with dry ice.
缓冲液:
Supplied as a 0.22 μm filtered solution in 100mM Pro-Ac, 20 mM Arg, pH 5.0
储存条件:
Store at -80°C for 2 years. Aliquots should be stored at the same temperature after first use to avoid
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