Ieramilimab - #BF6251
产品描述
货号:
BF6251
简介:
Ieramilimab (LAG525; IMP701) is a humanized IgG4 monoclonal antibody that binds to LAG-3, resulting in inhibition of LAG-3 interaction with MHC-II molecules. Ieramilimab restores T-cell and NK-cell-mediated antileukemic immunity by reducing exhaustion and augmenting cytokine output and cytotoxicity. Ieramilimab increases the infiltration of cytotoxic T lymphocytes and reduces baseline densities of regulatory T cells (Tregs) and ADAM10-expressing tumor cells. Ieramilimab can be used for the study of various malignancies including melanoma, RCC, and advanced solid tumors.
别名:
埃拉利单抗; LAG525; IMP701; Hu5A8
靶标:
LAG3/CD223
蛋白ID:
P18627
基因ID:
3902
分子量:
146.78 kDa
应用:
FACS, ELISA, Functional assay
反应:
Human
CAS NO.:
2137049-37-5
运输方式:
Shipping with dry ice.
缓冲液:
Supplied as a 0.22 μm filtered solution in 0.1M Na3C6H507 2H2O, 0.2NaCl, pH 5.0
储存条件:
Store at -80°C for 2 years. Aliquots should be stored at the same temperature after first use to avoid
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