| 产品: | Claudin 8 抗体 |
| 货号: | DF3947 |
| 描述: | Rabbit polyclonal antibody to Claudin 8 |
| 应用: | WB IF/ICC |
| 反应: | Human |
| 预测: | Bovine, Horse, Sheep, Rabbit |
| 分子量: | 28 KD; 25kD(Calculated). |
| 蛋白号: | P56748 |
| RRID: | AB_2836300 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF3947, RRID:AB_2836300.
展开/折叠
Claudin 8; Claudin-8; CLD8_HUMAN; Cldn8; Epididymis secretory protein Li 79; HEL S 79; OTTHUMP00000101915;
抗原和靶标
- P56748 CLD8_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MATHALEIAGLFLGGVGMVGTVAVTVMPQWRVSAFIENNIVVFENFWEGLWMNCVRQANIRMQCKIYDSLLALSPDLQAARGLMCAASVMSFLAFMMAILGMKCTRCTGDNEKVKAHILLTAGIIFIITGMVVLIPVSWVANAIIRDFYNSIVNVAQKRELGEALYLGWTTALVLIVGGALFCCVFCCNEKSSSYRYSIPSHRTTQKSYHTGKKSPSVYSRSQYV
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P56748 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y67 | Phosphorylation | Uniprot | |
| S69 | Phosphorylation | Uniprot | |
| S74 | Phosphorylation | Uniprot | |
| Y197 | Phosphorylation | Uniprot | |
| S198 | Phosphorylation | Uniprot | |
| T211 | Phosphorylation | Uniprot | |
| S215 | Phosphorylation | Uniprot | |
| S217 | Phosphorylation | Uniprot |
研究背景
Tight-junction protein required for paracellular chloride transport in the kidney. Mediates recruitment of CLDN4 to tight junction in the kidney. Claudins play a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
Ubiquitinated by the BCR(KLHL3) E3 ubiquitin ligase complex in the kidney, leading to its degradation.
Cell junction>Tight junction. Cell membrane>Multi-pass membrane protein.
Note: Localizes to tight junctions in all 3 segments of the epididymis, in the caput found in the lateral margins of principal cells, and in the corpus at the interface between basal and principal cells.
Expressed in the epididymis, mainly in the caput segment.
Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3. Interacts with CLDN4. Interacts with KLHL3.
Belongs to the claudin family.
研究领域
· Cellular Processes > Cellular community - eukaryotes > Tight junction. (View pathway)
· Environmental Information Processing > Signaling molecules and interaction > Cell adhesion molecules (CAMs). (View pathway)
· Human Diseases > Infectious diseases: Viral > Hepatitis C.
· Organismal Systems > Immune system > Leukocyte transendothelial migration. (View pathway)
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